NEUROCOGINTION MODULE

神经认知模块

• 批准号: 6722497
• 负责人: RALPH E TARTER
• 金额: $ 21.05万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6722497
• 关键词: adolescence (12-20); behavior prediction; behavioral /social science research tag; developmental psychology; disease /disorder etiology; disease /disorder onset; disease /disorder proneness /risk; electroencephalography; environmental stressor; evoked potentials; family structure /dynamics; father child interaction; gender difference; human subject; longitudinal human study; male; middle childhood (6-11); neuropsychological tests; neuropsychology; patient oriented research; phenotype; psychobiology; reproductive development; substance abuse related behavior; substance abuse related disorder

The proposed investigations continue ongoing efforts since inception of the Center to clarify the role of neurocognitive processes, specifically the executive cognitive functions(ECF), on the liability for a DSM-IV substance use disorder(SUD). Research conducted to date has shown that ECF capacity discriminates high average risk (HAR) from low average risk (LAR) youth ascertained on the basis of presence/absence of SUD in the proband father. In addition, emerging data indicate that ECF capacity in late childhood may bean important factor, albeit comparatively unstudied, influencing adolescent substance use (age 16) and the transition to SUD by young adulthood (age 19). In the forthcoming five year period, research in the Neurocognition Module will be extended to clarify the impact of ECF on SUD liability and its developmental course in relation to sexual maturation and environmental adversity. As a putativeSUD liability phenotype, the familial transmissibilityof ECF capacitywill also be determined .In as much as at least 107 male subjects in the sample are expected to transition to SLID by 22 years of age, CEDAR's longitudinal paradigm is uniquely positioned to determine the contribution of neurocognitive processes on the origins and pathways to SUD.

自该中心成立以来，拟议的调查继续不断努力，以澄清神经认知过程，特别是执行认知功能 (ECF) 在 DSM-IV 物质使用障碍 (SUD) 责任中的作用。迄今为止进行的研究表明，ECF 能力可根据先证者父亲是否存在 SUD 来区分高平均风险 (HAR) 和低平均风险 (LAR) 青少年。此外，新出现的数据表明，儿童晚期的 ECF 能力可能是影响青少年物质使用（16 岁）和成年早期（19 岁）向 SUD 过渡的重要因素（尽管相对而言尚未进行研究）。 在未来五年内，神经认知模块的研究将得到扩展，以阐明 ECF 对 SUD 责任的影响及其与性成熟和环境逆境相关的发展过程。作为假定的 SUD 责任表型，ECF 能力的家族遗传性也将被确定。样本中至少有 107 名男性受试者预计将在 22 岁时过渡到 SLID，CEDAR 的纵向范式具有独特的地位，可以确定SUD 起源和途径的神经认知过程。