Mentoring Junior Investigators: Comprehensive HIV Prevention

指导初级研究者：全面的艾滋病毒预防

• 批准号: 8735975
• 负责人: CAROL E GOLIN
• 金额: $ 15.79万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-17 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735975
• 关键词: AIDS prevention; AIDS/HIV problem; Achievement; Address; Adherence; Affect; Behavior; Behavior Therapy; Behavioral; Caring; Censuses; Collaborations; Communication; Communities; Crime; Data; Development; Diagnosis; Disease Progression; Education; Effectiveness; Epidemic; Food; Gender; Generations; Goals; HIV; HIV prevention trials network; HIV risk; Health; Health Care Costs; Health Services Accessibility; Health behavior; Heterosexuals; Imprisonment; Incidence; Individual; Infection; International; Intervention; Interview; Investigation; K-Series Research Career Programs; Life; Low income; Mentors; Midcareer Investigator Award in Patient-Oriented Research; Minority; Motivation; Neighborhoods; North Carolina; Observational Study; Participant; Poverty; Prevalence; Prevention; Prevention program; Preventive Intervention; Program Effectiveness; Public Health; Research; Research Personnel; Risk; Risk Behaviors; Risk Reduction; Role; Rosa; Self Efficacy; Single-Parent Family; Social Network; Stress; Testing; Time; Training; Underrepresented Minority; Unsafe Sex; Viral Load result; Woman; Work; arm; base; behavioral/social science; career; career development; condoms; contextual factors; cost; cost effectiveness; high risk; high risk sexual behavior; housing instability; improved; innovation; interest; intervention program; literacy; male; medication compliance; meetings; member; motivational enhancement therapy; patient oriented; patient oriented research; prevent; programs; public health relevance; response; safer sex; skills; social norm; social stigma; standard care; transmission process; treatment program

DESCRIPTION (provided by applicant): This is a proposal for a midcareer investigator award in patient-oriented research (K24) for Dr. Carol Golin. Despite efforts to curb HIV spread, incidence continues to increase in the southern U.S. Behavioral programs that address risky sexual behavior and ARV adherence can improve HIV transmission-related health behaviors of individuals, but are limited. Interpersonal and community-level factors, such poverty, social norms, crime and incarceration rates, interpersonal stress, and dyadic capacity often drive or constrain vulnerability to HIV, and may impede effects of behavioral programs. There is an urgent need for a pipeline of beginning investigators, especially those from underrepresented groups, with the interest and skills to collaboratively address these factors. As Director of the UNC CFAR Social and Behavioral Science Core, Dr. Golin is increasingly called upon to mentor numerous promising young investigators seeking to work with her to obtain such skills. The proposed career development award will give Dr. Golin the dedicated time to expand and build her patient- oriented research in HIV/AIDS prevention by mentoring several talented junior colleagues at UNC in HIV prevention and adherence research. Dr. Golin aims to create a formal UNC Program on HIV Prevention in the US South by achieving four immediate goals, to: 1) enhance her capacity to evaluate structural determinants of health and cost-effectiveness of HIV prevention intervention programs through formal and informal training and collaboration; 2) extend her patient-oriented investigations (exploring the interface between motivation, self- efficacy, and risky sexual behavior) by examining the role of interpersonal and community-level determinants of the HIV epidemic in influencing the effectiveness of HIV prevention programs; 3) evaluate the cost- effectiveness of the "Individuals Motivated to Participate and Adhere to Care and Treatment" (imPACT) HIV prevention program; and 4) enhance her capacity to provide effective and outstanding mentoring to junior investigators. The patient-oriented research proposed in this application, which provides a vehicle for career development for Dr. Golin and her mentees, will: 1) Examine the moderating effects of interpersonal and structural factors on the SafeTalk program's effectiveness among heterosexual HIV-infected individuals; 2) Explore the views of heterosexual participants in the imPACT study and their social network members to assess dyadic and community factors that helped or impeded their use of adherence or safer sex strategies.; 3) Evaluate the cost-effectiveness of the imPACT program; 4) Explore potential neighborhood and dyadic contexts for HIV risk among HIV-negative women and their male partners living in high poverty, high HIV prevalence census tracts in in NC. Her long-term career objective is to grow the HIV Prevention Program she is developing to a fully established Center for creating, testing, and disseminating effective, comprehensive HIV prevention interventions for vulnerable communities throughout the Southeastern U.S.

描述（由申请人提供）：这是Carol Golin博士的中级护理研究者奖（K24）的提案。尽管努力遏制艾滋病毒传播，但美国南部行为计划的发病率仍在继续增加，以解决风险的性行为和ARV依从性可以改善个人与艾滋病毒传播相关的健康行为，但有限。人际交往和社区级别的因素，例如贫困，社会规范，犯罪和监禁率，人际压力和二元能力通常会驱动或限制艾滋病毒的脆弱性，并可能影响行为计划的影响。迫切需要开始研究人员，尤其是来自代表性不足的团体的调查人员，并具有协作解决这些因素的兴趣和技能。作为UNC CFAR社会和行为科学核心的主任，Golin博士越来越多地指导许多有前途的年轻调查人员，他们寻求与她合作以获得此类技能。拟议的职业发展奖将使Golin博士有专门的时间来扩展和建立她以患者为导向的艾滋病毒/艾滋病预防研究，通过指导UNC的艾滋病毒预防和依从性研究的几位才华横溢的初级同事。 Golin博士旨在通过实现四个即时目标，以：1）提高她通过正式和非正式培训和协作来评估HIV预防干预计划的结构性决定因素的能力来制定一项关于美国南部的HIV预防艾滋病毒预防计划的正式计划； 2）通过检查艾滋病毒流行病在影响艾滋病毒预防计划的有效性方面的人际关系和社区级别的决定因素的作用，扩展了她以患者为导向的研究（探索动机，自我效能和风险性行为之间的接口）； 3）评估“有动力参与并遵守护理和治疗的个人”（影响）艾滋病毒预防计划的成本效益； 4）增强了她为初级调查人员提供有效和出色指导的能力。本应用程序中提出的面向患者的研究为Golin博士及其受训者提供了职业发展的工具，将：1）研究跨性别和结构性因素对Safetalk计划在异性恋HIV感染者中的有效性的调节作用； 2）探讨影响研究中异性恋参与者及其社交网络成员的观点，以评估有助于或阻碍其使用依从性或更安全的性策略的二元和社区因素。 3）评估影响计划的成本效益； 4）探索艾滋病毒阴性妇女及其男性伴侣的艾滋病毒风险的潜在邻里和二元背景，居住在北卡罗来纳州的高贫困，高艾滋病毒流行率普查。她的长期职业目标是制定她正在开发的艾滋病毒预防计划，以创建，测试和传播美国东南部脆弱社区的有效，全面的艾滋病毒预防干预措施，以创建，测试和传播有效的，全面的HIV预防干预措施。