Food Cues, Stress, Motivation for Highly Palatable Foods and Weight Gain

食物暗示、压力、对美味食物的动机和体重增加

• 批准号: 9113208
• 负责人: Rajita Sinha
• 金额: $ 16.65万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9113208
• 关键词: Address; Automobile Driving; Behavioral; Binge Eating; Biochemical; Biological; Bite; Body mass index; Brain; Calories; Cardiovascular Diseases; Chronic Disease; Complex; Cues; Development; Dietary intake; Disease; Eating; Emotional Stress; Emotions; Environment; Epidemic; Event; Exposure to; Food; Future; Glucocorticoids; Glucose; Health; Human; Hunger; Hyperphagia; Individual; Individual Differences; Insulin Resistance; Intake; Intervention; Laboratories; Lead; Leptin; Life; Malignant Neoplasms; Measures; Medical; Metabolic; Metabolic stress; Metabolism; Methods; Modeling; Motivation; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Obesity; Outpatients; Overweight; Pathway interactions; Pattern; Physical activity; Physiological; Population; Procedures; Relative (related person); Rewards; Stress; Stressful Event; System; Testing; Therapeutic; Touch sensation; United States; Weight; Weight Gain; Woman; base; biobehavior; burden of illness; clinically significant; cost effective; craving; design; follow-up; food craving; innovation; insulin sensitivity; lean body mass; men; method development; neuropsychiatry; novel; obesity risk; prospective; research study; response; restraint; transmission process; treatment strategy

DESCRIPTION (provided by applicant): Obesity is a global epidemic that greatly increases chronic disease burden. Overeating of highly palatable (HP) foods, especially in the ubiquitous food cue environment and in the context of stressful life events, are known to promote HP food craving, intake and weight gain, but the differential biobehavioral mechanisms underlying these effects is unclear. Using a novel experimental paradigm, promising preliminary results indicated that brief exposure to food cue and to emotional stress increases motivation for and intake of HP snack foods in the laboratory, more so in overweight (OW/OB) than in lean (LN) individuals. Furthermore, OW/OB individuals show altered biological stress and metabolic states with different biobehavioral responses during food cue and stress exposures which predict HP food craving and intake. On the basis of these results, we propose a 5-year experimental study with a prospective 2-year longitudinal follow-up in healthy men and women categorized on the basis of lean (body mass index: BMI<25), overweight (BMI=25-29.9) and obese Class I (BMI=30-35) groups to test the hypothesis that food cue and stress will increase HP food craving and intake, and higher BMI-related metabolic and stress system adaptations will predict HP food motivation and intake, which in turn, will promote future weight gain and obesity. The specific aims are: (1) to examine if exposure to food cue and to stress vs. neutral relaxing cues differentially increase HP food craving, eating topography, emotion, hunger and alters physiological and biochemical responses, and if changes vary across BMI groups; (2) to assess differential increases in HP food intake in each condition and whether it varies as a function of BMI group; (3) to identify whether HP food craving, emotion, hunger, physiological and metabolic responses is predictive of eating topography measures, calories and weight of HP food intake in each condition; (4) to assess whether stress- and food cue-induced HP food craving, intake and laboratory responses are predictive of food motivation, dietary intake and weight gain over the 2-year follow-up period; and (5) to explore the influence of key individual differences variables of cumulative stress, eating patterns, and physical activity on stress and cue-related responses and food intake in the laboratory and on motivation for HP food intake in the two-year follow-up period. Successful completion of the project will lead to an innovative and valid method to model of HP food craving and intake in the laboratory, which may be utilized for testing novel intervention strategies to decrease high levels of food motivation, overeating and obesity risk.

描述（由申请人提供）：肥胖是一种全球流行病，可大大增加慢性病负担。众所周知，在无处不在的食物提示环境和压力大的生活事件中，暴饮暴食（HP）食品，尤其是在无处不在的食物提示环境中，可以促进HP食品的渴望，摄入和体重增加，但是这些作用的差异性生物行为机制尚不清楚。使用新颖的实验范式，有希望的初步结果表明，短暂接触食物提示和情绪压力会增加实验室中HP零食食品的动机和摄入，而在超重（OW/OB）中，而不是在（LN）个体中。此外，OW/OB个体在食物提示和压力暴露期间具有不同的生物行为反应的生物胁迫和代谢状态变化，这些反应预测了HP食品的渴望和摄入量。 On the basis of these results, we propose a 5-year experimental study with a prospective 2-year longitudinal follow-up in healthy men and women categorized on the basis of lean (body mass index: BMI<25), overweight (BMI=25-29.9) and obese Class I (BMI=30-35) groups to test the hypothesis that food cue and stress will increase HP food craving and intake, and higher BMI-related metabolic压力系统的适应能力将预测HP食品动机和摄入量，这反过来将促进未来的体重增加和肥胖。具体目的是：（1）检查是否暴露于食物提示和强调中性的放松线索会差异增加HP食品的渴望，进食地形，情感，饥饿和改变生理和生化反应，以及在BMI群体中的变化是否变化； （2）评估在每种情况下HP食物摄入的差异增加以及它是否随BMI组的函数而变化； （3）确定HP食品渴望，情感，饥饿，生理和代谢反应是否可以预测在每种情况下饮食地形，卡路里和HP食物摄入量的重量； （4）评估压力和食品提示引起的HP食物的渴望，摄入量和实验室的反应是否可以预测食物动机，饮食摄入和体重增加2年的随访期； （5）探索累积压力，饮食模式以及体育锻炼对压力和提示相关的反应和食物摄入量的关键个体差异变量的影响，并在两年的随访期间对HP食物摄入的动机。该项目的成功完成将导致一种创新且有效的方法，以模型在实验室中渴望和摄入量的模型，该方法可以用于测试新颖的干预策略，以降低高水平的食物动机，暴饮暴食和肥胖风险。