Core Support for Cancer Center

癌症中心的核心支持

• 批准号: 8135903
• 负责人: Israel DAVID GOLDMAN
• 金额: $ 84.94万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8135903
• 关键词: Core; Support; Cancer; Center

This is an application for renewed CCSG funding for year 35 of the Albert Einstein Cancer Center which received its first NCI designation in 1972. There are seven established programs. These include: Immunooncology (Scharff), Tumor Microenvironment and Metastasis (Condeelis), Cell Growth and Differentiation control (Skoultchi), Molecular Membrane Biology (Stanley), Experimental Therapeutics (Horwitz), Cancer Epidemiology (Rohan) and the Biology of Colon Cancer (Augenlicht). The enhanced cancer focus of AECC programs is reflected in an increase in NCI grants from 74 in 2000 to 95 in 2006 with NCI support to AECC members currently at $19.4M (direct). There are two new NCI-funded programmatic grants: an NCI program project grant on Motility and Invasion and a U54 Center grant on Nutritional-Genetic Interactions in Intestinal Cancer. There has been recruitment of 43 new AECC members of whom 30 are new to Einstein. There have been major recruitments to clinical oncology leadership positions including new chairs of Medical Oncology (Perez-Soler), Pediatric Hematology/Oncology (Gorlick) and Radiation Oncology (Kalnicki). There are now 121 AECC members. The External Scientific Advisory Committee has convened yearly and consists of eleven members. There are nine established shared resources including Proteomics, Structural Biology (X-ray, Synchrotron, NMR), FACS, Analytical Imaging, Histopathology, Transgenic, Animal Barrier, Gene Targeting, and Genomics (DNA sequencing + microarray services). A Biostatistics Shared Resource was funded through a supplement to the CCSG since the last review and is included in this application. New shared resources for which funding is requested include Bioinformatics, Genome Imaging (FISH/SKY), and Epidemiology Informatics. A new research facility, the Michael F. Price Center for Translational and Genetic Medicine will open December 2007 and will provide 20,000 ft2 for the Animal Barrier, Transgenic, Histopathology, and Gene Targeting Shared Resources. A substantial number of new AECC recruits will be housed in this facility. Beyond this, there are plans to expand population sciences through continued recruitment to the Cancer Epidemiology program and recruitment of behavioral/prevention scientists.

这是为阿尔伯特·爱因斯坦癌症中心第 35 年更新 CCSG 资助的申请，该中心于 1972 年首次获得 NCI 称号。目前有七个既定项目。这些包括：免疫肿瘤学（Scharff）、肿瘤微环境和转移（Condeelis）、细胞生长和分化控制（Skoultchi）、分子膜生物学（Stanley）、实验治疗学（Horwitz）、癌症流​​行病学（Rohan）和结肠癌生物学（奥根利希特）。 AECC 项目对癌症重点的加强体现在 NCI 拨款从 2000 年的 74 项增加到 2006 年的 95 项，其中 NCI 对 AECC 成员的支持目前为 1940 万美元（直接）。 NCI 资助了两项新的计划拨款：NCI 关于运动和侵袭的计划项目拨款和 U54 中​​心关于肠癌营养-遗传相互作用的拨款。 AECC 已招募 43 名新会员，其中 30 名是爱因斯坦新会员。临床肿瘤学领导职位进行了大规模招聘，包括内科肿瘤学 (Perez-Soler)、儿科血液学/肿瘤学 (Gorlick) 和放射肿瘤学 (Kalnicki) 的新主席。 AECC现有会员121名。外部科学咨询委员会每年召开一次会议，由十一名成员组成。 有九个已建立的共享资源，包括蛋白质组学、结构生物学（X射线、同步加速器、核磁共振）、FACS、分析成像、组织病理学、转基因、动物屏障、基因打靶和基因组学（DNA测序+微阵列服务）。自上次审查以来，生物统计共享资源通过 CCSG 的补充获得资助，并包含在本申请中。需要资助的新共享资源包括生物信息学、基因组成像 (FISH/SKY) 和流行病学信息学。新的研究设施迈克尔·F·普莱斯转化和遗传医学中心将于 2007 年 12 月开放，并将为动物屏障、转基因、组织病理学和基因靶向共享资源提供 20,000 平方英尺的空间。大量 AECC 新员工将被安置在该设施中。除此之外，还计划通过继续招募癌症流行病学项目和招募行为/预防科学家来扩大人口科学。