Developing an Electrochemical Assay to Detect Nerve Regeneration in 3D Scaffolds
开发电化学检测方法来检测 3D 支架中的神经再生
基本信息
- 批准号:8444879
- 负责人:
- 金额:$ 7.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-01-15 至 2014-12-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAlginatesAmyotrophic Lateral SclerosisAnalytical ChemistryAnimal ModelAnimalsApplications GrantsAtrophicBiocompatible MaterialsBiological AssayBiologyCell SurvivalChargeChitosanCollagenCommunicationDegenerative DisorderDetectionDevelopmentDevicesDiabetic NeuropathiesDimensionsDiseaseEngineeringEyeFailureFilmFutureGoalsGrowthHealthHumanIn VitroIndividualLamininLengthMeasurementMeasuresMedicalMedical ResearchMethodsModelingModificationMuscleMuscle ContractionNafionNatural regenerationNerveNerve RegenerationNeural ConductionNeuritesNeuronsOrganOutcomePSSO3PhaseProcessResearchRetinal DegenerationSepharoseSignal TransductionSolutionsStagingSurfaceSynapsesTechniquesTestingTimeTissue EngineeringTissuesTraumaWorkWorld Healthbasecarbon fiberclinically relevantdesigndetectorhuman tissueimprovedin vivoinsightmeetingsnerve supplyneuron losspublic health relevanceregenerativereinnervationrepairedresponserestorationscaffoldtwo-dimensional
项目摘要
DESCRIPTION (provided by applicant): The research objective of this proposal is to develop a method to detect whether regenerating neurons are communicating appropriately before they regrow to their target tissues. Currently, successful regeneration of nerves in vivo is evaluated by nerve conduction velocity and muscle contraction. The major drawback to currently available methods is that either complete reconnectivity or final reinnervation of target tissues must occur for testing to be possible. The proposed technique will utilize a multi-disciplinary approach to detect synaptic signals as a measure of proper nerve growth in the initial stages of regeneration, rather than waiting until the nerve has reconnected and innervated target tissues. The aims to accomplish this objective are (i) to characterize synaptic signals from neurons regrowing on a 2 dimensional surface, or within a 3 dimensional scaffold, and detected with an x-y multi-channel interdigitated array detector, and (ii) to design a 3 dimensional (x-y-z) interdigitated array detector to measure synaptic signals from regrowing neurons within clinically relevant 3D scaffold materials. The long-term outcome of this project has the potential to meet the global need for a practical and inexpensive method to rapidly assess the efficacy of nerve regeneration.
描述(由申请人提供):该提案的研究目标是开发一种方法来检测再生神经元是否在重生为目标组织之前适当地通信。目前,通过神经传导速度和肌肉收缩来评估体内神经的成功再生。当前可用方法的主要缺点是,必须进行完全重新连接或最终重新连接以进行测试。所提出的技术将利用多学科的方法来检测突触信号,以衡量在再生初始阶段的适当神经生长,而不是等到神经重新连接和支配的靶组织。 The aims to accomplish this objective are (i) to characterize synaptic signals from neurons regrowing on a 2 dimensional surface, or within a 3 dimensional scaffold, and detected with an x-y multi-channel interdigitated array detector, and (ii) to design a 3 dimensional (x-y-z) interdigitated array detector to measure synaptic signals from regrowing neurons within clinically relevant 3D scaffold 材料。该项目的长期结果有可能满足全球对实际且廉价的方法的需求,以快速评估神经再生的疗效。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AMY B HARKINS其他文献
AMY B HARKINS的其他文献
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{{ truncateString('AMY B HARKINS', 18)}}的其他基金
Developing an Electrochemical Assay to Detect Nerve Regeneration in 3D Scaffolds
开发电化学检测方法来检测 3D 支架中的神经再生
- 批准号:
8603858 - 财政年份:2013
- 资助金额:
$ 7.5万 - 项目类别:
Homologous Recombination in a Secretory Mouse Cell Line
分泌型小鼠细胞系中的同源重组
- 批准号:
6683289 - 财政年份:2001
- 资助金额:
$ 7.5万 - 项目类别:
Homologous Recombination in a Secretory Mouse Cell Line
分泌型小鼠细胞系中的同源重组
- 批准号:
6572294 - 财政年份:2001
- 资助金额:
$ 7.5万 - 项目类别:
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