Immunology Training Program - Predoctoral
免疫学培训计划 - 博士前
基本信息
- 批准号:8263974
- 负责人:
- 金额:$ 17.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-15 至 2015-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The goal of the Immunology Training Program (ITP) is to train PhD and MD/PhD scientists for outstanding careers in immunology-related research. The program includes a wide range of Immunology-related topics, spanning from basic research in areas such as innate immunity, T cell activation, tolerance, antigen processing and presentation, MHC function, complement, antibody structure and function, and mucosal immunity to research in clinically relevant models of infectious diseases (e.g. tuberculosis, HIV), vaccine development, immunopathology, transplantation and autoimmunity. Participating departments provide a rich confluence of basic science and clinical activities and resources, enriching the training of PhD students as they engage in basic and/or translational research in the field of immunology. To accomplish these training goals, the ITP has been developed as a track within the Pathology Graduate Program. Training for the PhD degree in the ITP includes course work, research rotations, formal and informal seminars, a Thesis Proposal Defense/Qualifying Examination, and research experience resulting in scholarly publications and a PhD dissertation. Trainers and research laboratories are located in multiple departments at Case School of Medicine and its affiliated institutions. University Hospitals Case Medical Center (UHCMC), the Cleveland Clinic Foundation (CCF, including the Lerner Research Institute) and the Louis Stokes VA Medical Center (VAMC). The extensive inter-departmental and inter-institutional participation is underscored by explicit co-sponsorship of the ITP by the CWRU Department of Pathology, CCF Department of Immunology, CWRU/UHCMC Division of Infectious Diseases, CWRU Center for Global Health and CWRU/UHCMC Visual Sciences Research Center. Other ITP trainers are located in a wide number of other departments at Case, CCF, UHCMC, MHMC and VAMC. Regardless of their primary affiliation, ITP Trainers hold faculty or trainer appointments in the Case Department of Pathology.
RELEVANCE: The Immunology Training Program provides PhD training to produce future investigators who will drive important biomedical research efforts in Immunology and Immunology-related areas of clinical importance, such as infectious diseases, vaccine development, and organ transplantation autoimmunity.
描述(由申请人提供):免疫学培训计划(ITP)的目标是培训博士和医学博士/博士科学家,使其在免疫学相关研究领域取得杰出的职业生涯。该计划包括广泛的免疫学相关主题,从先天免疫、T 细胞激活、耐受、抗原加工和呈递、MHC 功能、补体、抗体结构和功能以及粘膜免疫等领域的基础研究到传染病(例如结核病、艾滋病毒)的临床相关模型、疫苗开发、免疫病理学、移植和自身免疫。参与部门提供了丰富的基础科学和临床活动和资源,丰富了博士生在免疫学领域从事基础和/或转化研究的培训。为了实现这些培训目标,ITP 已被开发为病理学研究生计划中的一个轨道。 ITP 博士学位培训包括课程作业、研究轮转、正式和非正式研讨会、论文提案答辩/资格考试以及学术出版物和博士论文的研究经验。凯斯医学院及其附属机构的多个系设有培训师和研究实验室。大学医院凯斯医疗中心 (UHCMC)、克利夫兰诊所基金会 (CCF,包括勒纳研究所) 和路易斯斯托克斯退伍军人医疗中心 (VAMC)。 CWRU 病理学系、CCF 免疫学系、CWRU/UHCMC 传染病科、CWRU 全球健康中心和 CWRU/UHCMC 视觉中心明确共同赞助 ITP,强调了广泛的跨部门和跨机构参与科学研究中心。其他 ITP 培训师分布在 Case、CCF、UHCMC、MHMC 和 VAMC 的许多其他部门。无论其主要隶属关系如何,ITP 培训师都在病例病理学部担任教员或培训师。
相关性:免疫学培训计划提供博士培训,以培养未来的研究人员,他们将推动免疫学和具有临床重要性的免疫学相关领域的重要生物医学研究工作,例如传染病、疫苗开发和器官移植自身免疫。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Clifford V Harding其他文献
Phagosomal Processing of Mycobacterium tuberculosis Antigen 85B Is Modulated Independently of Mycobacterial Viability and Phagosome Maturation
结核分枝杆菌抗原 85B 的吞噬体加工独立于分枝杆菌活力和吞噬体成熟进行调节
- DOI:
10.1128/iai.73.2.1097-1105.2005 - 发表时间:
2005-02-01 - 期刊:
- 影响因子:3.1
- 作者:
L. Ramach;ra;ra;Jamie L. Smialek;Sam S. Shank;M. Convery;W. Boom;Clifford V Harding - 通讯作者:
Clifford V Harding
CCAAT/Enhancer-Binding Protein β and δ Binding to CIITA Promoters Is Associated with the Inhibition of CIITA Expression in Response to Mycobacterium tuberculosis 19-kDa Lipoprotein1
CCAAT/增强子结合蛋白 β 和 δ 与 CIITA 启动子的结合与结核分枝杆菌 19-kDa 脂蛋白反应中 CIITA 表达的抑制相关
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:4.4
- 作者:
Meghan E. Pennini;Y. Liu;Jianqi Yang;C. Croniger;W. Boom;Clifford V Harding - 通讯作者:
Clifford V Harding
The Mycobacterium tuberculosis 19-Kilodalton Lipoprotein Inhibits Gamma Interferon-Regulated HLA-DR and FcγR1 on Human Macrophages through Toll-Like Receptor 2
结核分枝杆菌 19 千道尔顿脂蛋白通过 Toll 样受体 2 抑制人类巨噬细胞上伽玛干扰素调节的 HLA-DR 和 FcγR1
- DOI:
10.1128/iai.71.8.4487-4497.2003 - 发表时间:
2003-08-01 - 期刊:
- 影响因子:3.1
- 作者:
A. Gehring;R. Rojas;D. Canaday;David L. Lakey;Clifford V Harding;W. Boom - 通讯作者:
W. Boom
Phosphoantigen Presentation by Macrophages to Mycobacterium tuberculosis-Reactive Vγ9Vδ2+ T Cells: Modulation by Chloroquine
巨噬细胞向结核分枝杆菌反应性 Vγ9Vγ2 T 细胞呈递磷酸抗原:氯喹的调节
- DOI:
10.1128/iai.70.8.4019-4027.2002 - 发表时间:
2002-08-01 - 期刊:
- 影响因子:3.1
- 作者:
R. Rojas;M. Torres;J. Fournié;Clifford V Harding;W. Boom - 通讯作者:
W. Boom
TLR2 on CD4+ and CD8+ T cells promotes control of Mycobacterium tuberculosis infection
CD4 和 CD8 T 细胞上的 TLR2 促进结核分枝杆菌感染的控制
- DOI:
10.1002/eji.202350715 - 发表时间:
2024-03-06 - 期刊:
- 影响因子:5.4
- 作者:
S. M. Reba;Qing Li;Sophia Onwuzulike;N. Nagy;Shane Fletcher;Kyle Parker;Rachel J Shaw;Katharine Umphred‐Wilson;Supriya Shukla;Clifford V Harding;W. Boom;R. Rojas - 通讯作者:
R. Rojas
Clifford V Harding的其他文献
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{{ truncateString('Clifford V Harding', 18)}}的其他基金
M. tuberculosis lipoprotein-TLR2 interactions
结核分枝杆菌脂蛋白-TLR2 相互作用
- 批准号:
7210380 - 财政年份:2006
- 资助金额:
$ 17.71万 - 项目类别:
M. tuberculosis lipoprotein-TLR2 interactions
结核分枝杆菌脂蛋白-TLR2 相互作用
- 批准号:
7739472 - 财政年份:2006
- 资助金额:
$ 17.71万 - 项目类别:
M. tuberculosis lipoprotein-TLR2 interactions
结核分枝杆菌脂蛋白-TLR2 相互作用
- 批准号:
7994850 - 财政年份:2006
- 资助金额:
$ 17.71万 - 项目类别:
M. tuberculosis lipoprotein-TLR2 interactions
结核分枝杆菌脂蛋白-TLR2 相互作用
- 批准号:
7329170 - 财政年份:2006
- 资助金额:
$ 17.71万 - 项目类别:
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