Interventional PhotoAcoustic Surgical System (i-PASS)

介入光声手术系统 (i-PASS)

• 批准号: 8636019
• 负责人: Emad M Boctor
• 金额: $ 18.96万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8636019
• 关键词: Ablation; Acoustics; Address; Anatomy; Biopsy; Brachytherapy; Calibration; Catheters; Computers; Data; Devices; Electromagnetics; Environment; Equipment; Excision; Family suidae; Feedback; Image; Imagery; Imaging Techniques; Intervention; Ionizing radiation; Kidney Neoplasms; Laparoscopic Surgical Procedures; Lasers; Light; Lighting; Liver neoplasms; Magnetic Resonance Imaging; Metals; Methods; Modeling; Monitor; Needle biopsy procedure; Needles; Operative Surgical Procedures; Optics; Organ; Patients; Physiologic pulse; Pilot Projects; Positioning Attribute; Procedures; Process; Radiofrequency Interstitial Ablation; Relative (related person); Robotics; Signal Transduction; Solid; Spottings; Sterility; Surface; Surgeon; System; Techniques; Technology; Time; Tissues; Ultrasonography; Vendor; Vision; Work; base; clinical application; design; experience; image processing; imaging modality; imaging probe; improved; in vivo; innovation; interest; interstitial; minimally invasive; next generation; novel; photoacoustic imaging; public health relevance; sensor; sound; tool; tumor

DESCRIPTION (provided by applicant): This project will develop novel photoacoustic ultrasound imaging techniques to enable accurate, reliable, and efficient fusion of intraoperative ultrasound (IOUS) images with preoperative images, real time video, and other data to assist surgeons in minimally invasive surgery and other interventional procedures. Ultrasound provides many advantages for intraoperative use, and interest in using IOUS in both open and laparoscopic surgery, in providing guidance for biopsies, tumor ablation, brachytherapy, and robotic surgery is growing. One significant factor limiting the use of IOUS is the necessity for the surgeon to relate the information in the ultrasound images to preoperative information such as CT or MRI images and to what he or she is seeing in a laparoscopic video monitor or in direct visualization. Computer-based information fusion and visualization systems have significant potential to overcome this limitation, provided that they can 1) reliably register IOUS images to the surgical scene as observed, e.g., by laparoscopic video; 2) continuously register IOUS and video to preoperative data; and 3) track surgical tools in IOUS images. Current systems typically relying on optical or electromagnetic (EM) navigational trackers have several limitations, including 1) system complexity; 2) accuracy limitations; 3) line-of-sight restrictionsor the presence of extra wires in the surgical field. Our specific aims for this R21 feasibility projct are as follows: Aim 1: Real-time fusion of IOUS and video images: Develop and evaluate innovative photoacoustic methods for real-time, continuous registration of intraoperative US to video camera coordinate systems. Aim 2: Real-time tracking of registered preoperative data: Demonstrate and evaluate real-time, continuous tracking and display of registered preoperative models in IOUS and video camera coordinates. Aim 3: Real-time identification and tracking of interstitial tools in IOUS: Develop illumination and processing methods for generating PA signals on interstitial tools. Demonstrate and evaluate the use of these methods for locating the tiny tines of a typical probe used in RF ablation of tumors in solid organs. Our basic hypothesis is that many of these limitations can be overcome by the novel application of intraoperative photoacoustic (PA) imaging methods to permit direct, real-time localization of fiducial points in ultrasound images. In PA imaging, short pulses of laser light are converted into acoustic signals that can be detected in ultrasound images. If multiple laser spots are projected onto an organ surface, they may be located both in video and in ultrasound, thus permitting direct registration of IOUS-to-camera coordinates. Similarly, PA imaging may be used to locate small, embedded markers inside tissue to permit real-time tracking of registered preoperative images and models relative to IOUS. And it may be used to locate points on interstitial surgical tools and probes, thus permitting direct registration and tracking relative to IOUS. We will evaluate the technology developed in artificial & ex vivo phantoms and in a small in vivo pilot study.

描述（由申请人提供）：该项目将开发新型的光声超声成像技术，以实现术中术中超声（IOUS）图像的准确，可靠和有效的融合，并具有术前图像，实时视频和其他数据，以帮助外科医生在微创手术和其他介入过程中帮助外科医生。超声为术中使用提供了许多优势，并有兴趣在开放和腹腔镜外科手术中使用IOUS，以提供活检，肿瘤消融，近距离治疗和机器人手术的指导。 限制使用IOU的一个重要因素是外科医生必须将超声图像中的信息与术前信息（例如CT或MRI图像）联系起来，以及他或她在腹腔镜视频监视器中看到的信息或直接可视化。基于计算机的信息融合和可视化系统具有克服此限制的巨大潜力，只要它们可以）可靠地注册 图像如观察到的手术场景，例如通过腹腔镜视频； 2）连续注册IOUS和视频以术前数据； 3）在IOUS图像中跟踪手术工具。当前的系统通常依靠光学或电磁（EM）导航跟踪器具有多个局限性，包括1）系统复杂性； 2）准确性限制； 3）视线限制者在外科手术场中存在额外的电线。 我们对R21可行性的特定目的如下：目标1：IOUS和视频图像的实时融合：开发和评估创新的光声方法，用于实时，术中美国对摄像机坐标系统的连续注册。 AIM 2：注册术前数据的实时跟踪：在IOUS和摄像机坐标中演示和评估实时，连续跟踪并显示注册的术前模型。目标3：在IOUS中的实时识别和跟踪间质工具：开发照明和处理方法，以在间隙工具上生成PA信号。证明并评估这些方法的使用来定位用于固体器官肿瘤的RF消融中的典型探针的微小尖端。 我们的基本假设是，通过新的术中光声（PA）成像方法的新应用可以克服许多这些局限性，以允许在超声图像中直接实时地定位基准点。在PA成像中，激光光的短脉冲被转化为可以在超声图像中检测到的声学信号。如果将多个激光斑投射到器官表面上，则它们可能位于视频和超声波中，从而可以直接注册IOUS到相机坐标。同样，PA成像可用于在组织内部定位小的嵌入式标记，以实时跟踪注册的术前图像和模型相对于IOUS。它可以用于定位间隙手术工具和探针上的点，从而可以相对于IOU进行直接的注册和跟踪。我们将评估在人工和外体型幻影中开发的技术以及一项小型体内试验研究。

项目成果

Active phantoms: a paradigm for ultrasound calibration using phantom feedback

主动体模：使用体模反馈进行超声校准的范例

• DOI: 10.1117/1.jmi.4.3.035001
• 发表时间: 2017
• 期刊: Journal of Medical Imaging
• 影响因子: 2.4
• 作者: Cheng, Alexis;Guo, Xiaoyu;Zhang, Haichong K.;Kang, Hyun Jae;Etienne-Cummings, Ralph;Boctor, Emad M.
• 通讯作者: Boctor, Emad M.