A Normal Paradigm to Monitor Perinatal Asphyxia Using A Combined Ultrasound-Neuromodulation and Photoacoustic-Imaging Device

使用超声神经调节和光声成像相结合的设备监测围产期窒息的正常范例

• 批准号: 10552231
• 负责人: Emad M Boctor
• 金额: $ 30万
• 依托单位: BRIMROSE TECHNOLOGY CORPORATION
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10552231
• 关键词: Acoustics; Address; Affect; Algorithms; Animal Model; Asphyxia Neonatorum; Biomedical Engineering; Birth; Brain; Brain Hypoxia-Ischemia; Brain Injuries; Brain Ischemia; Cerebral Palsy; Cerebral cortex; Cessation of life; Clinic; Clinical; Coupled; Data; Developed Countries; Developmental Delay Disorders; Devices; Diagnosis; Diagnostic; Diagnostic Equipment; Diagnostic Procedure; Diagnostic Reagent Kits; Early Diagnosis; Early Intervention; Epilepsy; Exposure to; Fetal Skull; Fetus; First Births; Frequencies; Glucose; Goals; Head; Hour; Human; Hypoxia; Image; Imaging Device; Injury; Intellectual functioning disability; Intervention; Ischemia; Joints; Length; Literature; Live Birth; Magnetic Resonance Imaging; Mediating; Methods; Modality; Modeling; Monitor; Neonatal; Neonatal Brain Injury; Neonatal Mortality; Neurologic; Neurology; Neurons; Newborn Infant; Ophthalmology; Optics; Oxygen; Pathway interactions; Patients; Placebos; Positioning Attribute; Psychiatry; Relaxation; Reperfusion Therapy; Research; Sampling; Slice; System; Techniques; Technology; Therapeutic; Therapeutic Intervention; Time; Ultrasonic Therapy; Universities; Uterine Contraction; Vascular blood supply; Work; autism spectrum disorder; base; brain tissue; clinical application; cranium; deprivation; design; diagnostic tool; disability; in silico; intrapartum; natural hypothermia; neonatal death; neonatal hypoxic-ischemic brain injury; neonatal morbidity; neonate; nerve injury; neural stimulation; neuroregulation; neurosurgery; non-invasive monitor; photoacoustic imaging; postnatal period; prototype; relating to nervous system; response; simulation; therapeutically effective; tool; ultrasound; Acoustics; Address; Affect; Algorithms; Animal Model; Asphyxia Neonatorum; Biomedical Engineering; Birth; Brain; Brain Hypoxia-Ischemia; Brain Injuries; Brain Ischemia; Cerebral Palsy; Cerebral cortex; Cessation of life; Clinic; Clinical; Coupled; Data; Developed Countries; Developmental Delay Disorders; Devices; Diagnosis; Diagnostic; Diagnostic Equipment; Diagnostic Procedure; Diagnostic Reagent Kits; Early Diagnosis; Early Intervention; Epilepsy; Exposure to; Fetal Skull; Fetus; First Births; Frequencies; Glucose; Goals; Head; Hour; Human; Hypoxia; Image; Imaging Device; Injury; Intellectual functioning disability; Intervention; Ischemia; Joints; Length; Literature; Live Birth; Magnetic Resonance Imaging; Mediating; Methods; Modality; Modeling; Monitor; Neonatal; Neonatal Brain Injury; Neonatal Mortality; Neurologic; Neurology; Neurons; Newborn Infant; Ophthalmology; Optics; Oxygen; Pathway interactions; Patients; Placebos; Positioning Attribute; Psychiatry; Relaxation; Reperfusion Therapy; Research; Sampling; Slice; System; Techniques; Technology; Therapeutic; Therapeutic Intervention; Time; Ultrasonic Therapy; Universities; Uterine Contraction; Vascular blood supply; Work; autism spectrum disorder; base; brain tissue; clinical application; cranium; deprivation; design; diagnostic tool; disability; in silico; intrapartum; natural hypothermia; neonatal death; neonatal hypoxic-ischemic brain injury; neonatal morbidity; neonate; nerve injury; neural stimulation; neuroregulation; neurosurgery; non-invasive monitor; photoacoustic imaging; postnatal period; prototype; relating to nervous system; response; simulation; therapeutically effective; tool; ultrasound

PROJECT SUMMARY The Brimrose Technology Corporation and partner, The Johns Hopkins University, propose using non-invasive ultrasound neuromodulation to identify hypoxic-ischemic encephalopathy (HIE) in newborns to reduce death and lifelong brain injury. HIE is the leading cause of neonatal death and impacts 2-6 of every 1,000 live births in the developed world. Our goal is to investigate and demonstrate the effect of graded hypoxia and repeated oxygen/glucose deprivation on neural response using ultrasound modulation. We will then develop and validate an ultrasound-neuromodulation coupled with photoacoustic-imaging device prototype to monitor neonatal brain injury. This device will be used for early diagnosis of HIE to enable timely intervention, which minimizes long-term disability. The two organizations have established a strong research team and joint operating lab at Hopkins to develop this system. Due to various limitations of current methods, there is an urgent need for an early HIE diagnostic kit to enable prompt therapeutic interventions. There are no early diagnostic procedures or devices available in the clinic for HIE. Hence, our proposal addresses a critical unmet need.

项目摘要 约翰·霍普金斯大学（Johns Hopkins University）的Brimrose技术公司和合作伙伴提出了 使用非侵入性超声神经调节来鉴定缺氧性缺血性脑病（HIE） 新生儿减少死亡和终生脑损伤。 Hie是新生儿死亡的主要原因， 在发达国家每1000个活产中影响2-6个。我们的目标是调查和证明 使用分级缺氧和反复氧/葡萄糖剥夺对神经反应的影响 超声调制。然后，我们将开发并验证超声神经调节结合 光声成像装置原型用于监测新生儿脑损伤。该设备将用于 HIE的早期诊断可以及时干预，从而最大程度地减少了长期残疾。两个 组织已经在霍普金斯建立了一个强大的研究团队和联合运营实验室，以开发 这个系统。由于当前方法的各种局限性，迫切需要早期的Hie 诊断套件以启用及时的治疗干预措施。没有早期诊断程序或 Hie诊所可用的设备。因此，我们的提议解决了一个至关重要的未满足需求。