Perceptual implications of cochlear implant electrode-neuron interfaces

人工耳蜗电极-神经元界面的感知影响

• 批准号: 8607527
• 负责人: JULIE G Arenberg
• 金额: $ 38.63万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8607527
• 关键词: Accounting; Acoustic Nerve; Affect; Auditory; Characteristics; Clinic; Cochlea; Cochlear Implants; Complex; Computer Simulation; Confusion; Cueing for speech; Development; Discrimination; Distant; Electrodes; Elements; Environment; Esthesia; Exhibits; Goals; Growth; Hearing; High Resolution Computed Tomography; Image; Implant; Implanted Electrodes; Individual; Knowledge; Lead; Location; Loudness; Maps; Masks; Measures; Medial; Music; Neurons; Outcome; Pathology; Patients; Pattern; Perception; Performance; Physiologic pulse; Population; Positioning Attribute; Procedures; Psychophysics; Radial; Relative (related person); Research; Resolution; Source; Speech; Speech Discrimination; Speech Perception; Stimulus; Techniques; Testing; Time; X-Ray Computed Tomography; base; clinical practice; hearing impairment; improved; neural prosthesis; novel; novel strategies; programs; relating to nervous system; sound; spiral ganglion; success; theories; tool

DESCRIPTION (provided by applicant): Cochlear implants are highly successful neural prostheses that enhance or restore hearing to the severely hearing impaired. However, performance varies considerably among cochlear implant listeners, particularly in noisy environments and for spectrally complex stimuli like music. Pathology and imaging studies suggest that two sources of performance variability are the distribution of surviving spiral ganglion neurons and their distance from individual CI electrodes. This proposal uses psychophysical measures, computed tomography imaging, and computer modeling to assess how such factors affect the function of individual cochlear implant channels. That information will be applied to reprogram the implant processor in order to minimize the influence of poorly functioning channels. Three aims are proposed: 1) To determine the degree to which thresholds obtained using a spatially focused electrode configuration correlate with single-channel measures of spectral resolution, loudness growth, and electrode position within the cochlea; 2) To quantify the contributions of channels with high thresholds on the discrimination of speech stimuli; and 3) To determine if listener-specific mapping tailored to the estimated electrode-neuron interface from Aim 1 can improve perception on complex listening tasks. The results of these studies are expected to advance the field's understanding of how cochlear implant channel position and neural survival affect single-channel and speech perception. The findings have the potential to shift clinical practice by providing a guide for patient-specific channel mapping and ultimately lead to improved speech perception abilities in cochlear implant listeners.

描述（由申请人提供）：人工耳蜗是非常成功的神经假体，可以增强或恢复严重听力受损者的听力。然而，人工耳蜗听者的性能差异很大，特别是在嘈杂的环境中和音乐等频谱复杂的刺激下。病理学和影像学研究表明，性能变异的两个来源是存活螺旋神经节神经元的分布及其与单个 CI 电极的距离。该提案使用心理物理测量、计算机断层扫描成像和计算机建模来评估这些因素如何影响个体人工耳蜗通道的功能。该信息将用于重新编程植入处理器，以尽量减少功能不良的通道的影响。提出了三个目标：1）确定使用空间聚焦电极配置获得的阈值与频谱分辨率、响度增长和耳蜗内电极位置的单通道测量的相关程度； 2）量化高阈值通道对语音刺激辨别的贡献； 3) 确定根据目标 1 估计的电极-神经元界面定制的听者特定映射是否可以改善对复杂听力任务的感知。这些研究的结果预计将促进该领域对人工耳蜗通道位置和神经存活如何影响单通道和语音感知的理解。这些发现有可能通过为患者特定的通道映射提供指导来改变临床实践，并最终提高人工耳蜗聆听者的言语感知能力。