Perceptual implications of cochlear implant electrode-neuron interfaces

人工耳蜗电极-神经元界面的感知影响

基本信息

批准号：
10705794
负责人：
JULIE G Arenberg
金额：
$ 60.12万
依托单位：
MASSACHUSETTS EYE AND EAR INFIRMARY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-02-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705794
关键词：
17 year old 2 year old Acclimatization Acoustic Nerve Action Potentials Adult Affect Age Auditory Auditory system Behavioral Child Chronic Clinical Cochlea Cochlear Implants Complex Crossover Design Cues Data Detection Development Devices Effectiveness Electric Stimulation Electrodes Electrophysiology (science)Environment Goals Grant Guidelines Hearing Hour Implant Implanted Electrodes Individual Knowledge Labyrinth Longevity Manufacturer Measures Methods Neurons Neurosciences Operative Surgical Procedures Outcome Participant Patients Performance Peripheral Physiologic pulse Physiological Population Progress Reports Protocols documentation Psychophysics Publications Research Resolution Signal Transduction Speech Perception Stimulus Testing Time Work age group clinical care clinical decision-making clinical practice critical period deaf density developmental plasticity electric field experience experimental study functional improvement hearing impairment improved innovation neural prosthesis new technology programs sound speech recognition success theories

项目摘要

Project Summary/Abstract Cochlear implants are highly successful neural prostheses that enhance or restore audition to severely hearing-impaired adults and children. Sound from the environment is converted into electrical pulses and conveyed to the auditory nerve by an array of electrodes. The cochlear implant provides important spectral and temporal information to the listener. However, speech perception performance varies considerably among cochlear implant listeners, particularly in noisy environments and for complex stimuli. This variability exists even for children who receive their cochlear implants early in development (<2 years old). Recent evidence suggests that children have a higher density of healthy auditory neurons, which are the target of stimulation through an implant. There is also a critical period for auditory developmental plasticity. The interaction of these factors and the chronic electrical stimulation of a cochlear implant are not well understood, especially for early-implanted children. Despite these known differences between adults and the immature auditory systems of children, cochlear implant research has focused on adults. In adults, the most promising methods for optimizing programming strategies include focusing the electrical field emitted by each electrode to stimulate a more restricted population of neurons and deactivating less effective electrodes. Very few attempts have been made to optimize programming strategies specifically for children, and recent evidence suggests children would benefit more than adults from focused stimulation. Moreover, when new programming strategies are implemented, there is limited data about the timecourse needed to assess their effectiveness. Three aims are proposed: 1) Determine the underlying mechanisms for spectral resolution in children and adults with cochlear implants by comparing peripheral physiological and behavioral tuning across the lifespan; 2) Quantify short-term changes (over hours) in speech perception in children and adults when using optimized programming strategies with selective channel deactivation with and without focused stimulation; and 3) Quantify long-term changes (over weeks) in speech perception in children and adults using the same optimized strategies as in Aim 2. The results of the proposed studies are expected to advance our understanding of how the implanted auditory system develops, how cochlear implants should be programmed to best deliver spectrally challenging signals, and the timecourse of acclimatization to changes in programming strategies. These findings could guide clinical decision making about when to make programming adjustments, what types of adjustments to make, and how long patients need to reach peak performance following adjustments. The results from these studies could ultimately lead to improved functional outcomes for children and adults with cochlear implants.

项目概要/摘要人工耳蜗是非常成功的神经假体，可以严重增强或恢复听力有听力障碍的成人和儿童。来自环境的声音被转换成电脉冲通过一系列电极传送到听觉神经。人工耳蜗提供重要的光谱和给听众的时间信息。然而，不同人的语音感知表现差异很大人工耳蜗聆听者，特别是在嘈杂的环境中和复杂的刺激下。这种变异性是存在的即使对于在发育早期（<2 岁）接受人工耳蜗植入的儿童也是如此。最近的证据表明，儿童拥有更高密度的健康听觉神经元，这些神经元通过植入物刺激的目标。听觉发育可塑性也有一个关键期。这些因素的相互作用和人工耳蜗的慢性电刺激效果不佳理解，特别是对于早植入的孩子。尽管成人和成人之间存在这些已知的差异由于儿童听觉系统尚未成熟，人工耳蜗的研究主要集中在成人身上。在成年人中，最优化编程策略的有前途的方法包括聚焦每个电极刺激更有限的神经元群体并停用效率较低的电极。非常很少有人尝试专门针对儿童优化编程策略，并且最近有证据表明，儿童比成人从集中刺激中受益更多。而且，当新规划战略已实施，但评估其所需时间进程的数据有限效力。提出了三个目标：1）确定儿童光谱分辨率的根本机制和植入人工耳蜗的成年人，通过比较外周生理和行为调节寿命; 2) 量化儿童和成人使用时言语感知的短期变化（数小时内）通过选择性通道停用（有或没有集中刺激）优化编程策略； 3) 使用相同的方法量化儿童和成人言语感知的长期变化（数周内）优化策略如目标 2 所示。拟议研究的结果预计将增进我们对植入物如何进行的理解听觉系统的发展，人工耳蜗应如何编程才能最好地提供具有挑战性的频谱信号，以及适应编程策略变化的时间过程。这些发现可以指导临床决策何时进行编程调整、调整类型进行调整，以及患者在调整后需要多长时间才能达到最佳表现。这些结果研究最终可能会改善植入人工耳蜗的儿童和成人的功能结果。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Comparing Fixed and Individualized Channel Interaction Coefficients for Speech Perception With Dynamic Focusing Cochlear Implant Strategies.

DOI：
10.1177/23312165231176157
发表时间：
2023-01
期刊：
TRENDS IN HEARING
影响因子：
2.7
作者：
Caswell-Midwinter, Benjamin;Arenberg, Julie G.
通讯作者：
Arenberg, Julie G.

A Modified Pediatric Ranked Order Speech Perception Score to Assess Speech Recognition Development in Children With Cochlear Implants.

改进的儿科排序言语感知评分，用于评估人工耳蜗植入儿童的言语识别发展。

DOI：
10.1044/2022_aja-21-00212
发表时间：
2022
期刊：
American journal of audiology
影响因子：
1.8
作者：
Arjmandi,MeisamK;Herrmann,BarbaraS;Caswell-Midwinter,Benjamin;Doney,ElizabethM;Arenberg,JulieG
通讯作者：
Arenberg,JulieG

An Examination of Sources of Variability Across the Consonant-Nucleus-Consonant Test in Cochlear Implant Listeners.