NEUROPATHOLOGY CORE

神经病理学核心

• 批准号: 8662621
• 负责人: JUAN TRONCOSO
• 金额: $ 21.65万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8662621
• 关键词: Address; Alzheimer' s Disease; Apolipoprotein E; Autopsy; Biological; Clinic; Clinical; Clinical Investigator; Communities; Consensus; DNA; Data; Databases; Dementia; Diagnosis; Diagnostic; Disease; Enrollment; Fostering; Genetically Engineered Mouse; Genotype; Goals; Histology; Institution; Laboratories; Liquid substance; Medical Research; Neurodegenerative Disorders; Participant; Patients; Phase; Research; Research Personnel; Sampling; Scientist; Specimen; Tissues; Training; brain tissue; cohort; computerized; immunocytochemistry; meetings; mild cognitive impairment; mouse model; neuropathology; neuropsychological

The Neuropathology Core (Core D) of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) has two overarching goals, one related to the analysis and distribution of brain tissue and other specimens from subjects in the ADRC, and the other related to the analysis of genetically engineered mouse models by investigators associated with the ADRC. The specific aims of Core D are as follows: (1) to arrange and perform autopsies on clinically well-characterized subjects enrolled through the JHMI ADRC and assist with consensus diagnoses on subjects associated with the ADRC (comprised of the Clinic Cohort and the BLSA Cohort). (2) to accession and store optimally prepared tissues from the autopsies and to make these specimens available to investigators associated with the ADRC and at other collaborating institutions. (3) to accession and store samples of biological fluids and DNA obtained pre- and postmortem from subjects in the ADRC. (4) to facilitate APOE genotyping on participants in the ADRC. (5) to support the assessment of genetically engineered mouse models relevant to Alzheimer's disease (AD) and related disorders, (6) to collaborate with the medical and research community outside of Johns Hopkins by providing assistance with postmortem diagnoses of AD and other types of dementia, and (7) to train basic investigators and clinical neuroscientists in the morphological and diagnostic concepts relevant to AD, to other types of dementias and neurodegenerative disorders.

约翰霍普金斯大学阿尔茨海默病研究中心 (ADRC) 的神经病理学核心 (Core D) 有两个总体目标，一个与 ADRC 受试者的脑组织和其他标本的分析和分布有关，另一个与分析ADRC 相关研究人员开发的基因工程小鼠模型。核心 D 的具体目标如下：(1) 对通过 JHMI ADRC 登记的临床特征良好的受试者安排和进行尸检，并协助对与 ADRC 相关的受试者（由临床队列和 BLSA 队列组成）达成共识诊断）。 (2) 加入并储存尸检中经过最佳准备的组织，并将这些标本提供给与 ADRC 和其他合作机构相关的研究人员。 (3) 在 ADRC 中加入和储存从受试者死前和死后获得的生物体液和 DNA 样本。 (4) 促进 ADRC 参与者的 APOE 基因分型。 (5) 支持与阿尔茨海默病 (AD) 和相关疾病相关的基因工程小鼠模型的评估，(6) 与约翰·霍普金斯大学以外的医学和研究界合作，为 AD 和其他类型的死后诊断提供帮助(7) 培训基础研究人员和临床神经科学家，了解与 AD、其他类型的痴呆和神经退行性疾病相关的形态学和诊断概念。