Research Education Program in Experimental Neuropathology

实验神经病理学研究教育计划

• 批准号: 8330473
• 负责人: JUAN TRONCOSO
• 金额: $ 5.17万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8330473
• 关键词: Administrative Supplement; Alzheimer' s Disease; Animal Model; Applications Grants; Award; Basic Science; Biological Markers; Biomedical Research; Clinical; Clinical Medicine; Communication; Dementia; Development; Diagnosis; Diagnostic tests; Disease; Education; Education Projects; Epilepsy; Ethics; Faculty; Fellowship; Funding; Goals; Grant; Human; Immersion Investigative Technique; Individual; Instruction; K-Series Research Career Programs; Laboratories; Mentored Patient-Oriented Research Career Development Award; Mentors; Microscopic; Molecular; Molecular Biology; Molecular Genetics; Monitor; Morbidity - disease rate; Neurodegenerative Disorders; Neurosciences; Oral; Parkinson Disease; Participant; Pathology; Peer Review; Physicians; Play; Preparation; Prevention; Process; Productivity; Public Health; Publications; Qualifying; Records; Recruitment Activity; Research; Research Activity; Research Personnel; Research Project Grants; Residencies; Scholarship; Science; Scientist; Staging; Stroke; Time; Tissues; Training; Training Programs; Translating; Traumatic Brain Injury; United States National Institutes of Health; Work; Writing; base; career; cellular imaging; clinical application; experience; insight; medical schools; mortality; multidisciplinary; nervous system disorder; neuro-oncology; neuropathology; next generation; novel; novel diagnostics; programs; relating to nervous system; skills; success; tool

DESCRIPTION (provided by applicant): There is a shortage of physician-scientists who can bridge basic research and clinical neurosciences. These are the individuals who can take the discoveries of basic science and use them to understand the mechanisms of neurological disorders such as Alzheimer's or Parkinson's disease or stroke, and to develop novel treatments and biomarkers. Neuropathologists play a key role in this process, as they are specifically trained to study the microscopic and molecular manifestations of disease. They can provide critical insights into the changes present in human neural tissues, as well as those of animal models and based on their unique perspective can generate novel hypotheses or form an essential part of multidisciplinary teams studying neurological disease. The goal of the Johns Hopkins Research Education Program in Experimental Neuropathology is to provide neuropathology residents and fellows with an intensive, mentored research experience during their residency or fellowship. This early immersion in research will help them to develop a research career and prepare them to successfully apply for NIH career development awards (KO8 and K23). To attain this goal, we have assembled a group of highly qualified mentors, both from neuropathology and other neurosciences departments, who will guide the research activities of the trainees. These mentors are physician-scientists and basic researchers with strong track records of independent funding and research, scholarship, and previous training of physician-scientists. Trainees will be selected based on their potential for becoming independent investigators and will be admitted to the program while in their neuropathology residency or fellowship. The trainees will then work for one or two years in the laboratory of a mentor, who will guide and supervise them. The plan for research will be jointly developed by the trainee and mentor and approved by the Program Executive Committee. The trainees will also attend courses in the ethical conduct of research and professional development (grant writing). They will also be able to apply for an Administrative Supplement of the award to extend their research experience once they complete their clinical training. While in the program, the trainees will start writing applications for KO8 or K23 awards. The success of the program will be evaluated by the number of trainees that apply for and succeed in obtaining career development awards (i.e. KO8 and K23) or other major research grants (i.e. R01), pursue research and academic careers, and author significant peer-reviewed publications. PUBLIC HEALTH RELEVANCE: Public Health Diseases of the nervous system such as dementia, stroke, epilepsy, and traumatic brain injury are common causes or morbidity and mortality. There is an urgent need to find new ways to diagnose and cure these conditions. New advances in basic sciences, including cell imaging, molecular biology and genetics, have created great opportunities that need to be translated into diagnostic tests and therapies for these neurological disorders. This R25 Neuropathology Research Education Program aims to train physician-scientists focused on Neuropathology who will be able to bridge the gap between basic research and clinical medicine, and to develop the next generation of diagnostic tools and therapies for neurological disorders.

描述（由申请人提供）：缺乏可以桥接基础研究和临床神经科学的医师科学家。这些人可以吸引基础科学发现并利用它们来了解神经系统疾病的机制，例如阿尔茨海默氏病或​​帕金森氏病或中风，并开发新的治疗方法和生物标志物。神经病理学家在这一过程中起着关键作用，因为他们经过专门研究疾病的显微镜和分子表现。他们可以为人类神经组织中存在的变化以及动物模型的变化提供关键的见解，并基于它们独特的观点可以产生新的假设或构成研究神经系统疾病的多学科团队的重要组成部分。约翰·霍普金斯（Johns Hopkins）实验神经病理学研究教育计划的目的是为神经病理学居民和研究员提供在居住或奖学金期间提供丰富的，有指导的研究经验。这种早期的研究将帮助他们发展研究职业，并准备成功申请NIH职业发展奖（KO8和K23）。为了实现这一目标，我们从神经病理学和其他神经科学部门组装了一群高素质的导师，他们将指导受训者的研究活动。这些导师是医师科学家和基础研究人员，具有独立资金和研究，奖学金以及先前对医师科学家的培训的良好记录。学员将根据他们成为独立调查员的潜力而被选出，并在其神经病理学居住或奖学金中被录取该计划。然后，学员将在导师的实验室工作一两年，他们将指导和监督他们。研究计划将由学员和导师共同制定，并由计划执行委员会批准。学员还将参加研究和专业发展的道德行为（授予写作）的课程。他们还将能够申请该奖项的行政补充，以扩大他们的研究经验，一旦完成临床培训。在计划中，学员将开始为KO8或K23奖项编写申请。该计划的成功将由申请并成功获得职业发展奖（即KO8和K23）或其他主要研究赠款（即R01），从事研究和学术职业的受训者的数量进行评估，并作者撰写了重要的同伴评审出版物。 公共卫生相关性：神经系统的公共卫生疾病，例如痴呆，中风，癫痫和脑损伤是常见原因或发病率和死亡率。迫切需要寻找诊断和治愈这些疾病的新方法。基础科学的新进展，包括细胞成像，分子生物学和遗传学，创造了很大的机会，需要将其转化为这些神经系统疾病的诊断测试和疗法。这项R25神经病理学研究教育计划旨在培训专注于神经病理学的医师科学家，他们将能够弥合基础研究和临床医学之间的差距，并开发下一代神经系统疾病的诊断工具和疗法。