Early diagnosis of colon cancer with computer-aided multi-energy CT colonography

计算机辅助多能CT结肠成像早期诊断结肠癌

• 批准号: 8621760
• 负责人: Janne Johannes Nappi
• 金额: $ 8.7万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-11 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8621760
• 关键词: Advisory Committees; Age; Algorithms; American Cancer Society; American College of Radiology; Appearance; Cancer Etiology; Cessation of life; Clinical; Colon; Colon Carcinoma; Colonoscopy; Colorectal; Colorectal Cancer; Computed Tomographic Colonography; Computer Assisted; Contrast Media; Databases; Dehydration; Detection; Development; Diagnosis; Diarrhea; Dose; Early Diagnosis; Evaluation; Goals; Guidelines; Image; Ingestion; Intestines; Iodine; Lead; Lesion; Medicare; Methods; Modality; Multi-Institutional Clinical Trial; Noise; Optics; Oral; Patients; Performance; Polypoid Lesion; Polyps; Population; Preparation; Protocols documentation; Radiation; Research; Risk; Safety; Scanning; Scheme; Societies; Source; Techniques; Testing; United States; Validation; Woman; X-Ray Computed Tomography; base; clinically significant; colorectal cancer screening; compliance behavior; computer aided detection; density; forest; improved; indexing; innovation; laxative; men; mortality; novel; older patient; patient population; prevent; public health relevance; radiologist; reconstruction; screening; soft tissue; success; virtual

DESCRIPTION (provided by applicant): Colon cancer, the second leading cause of cancer deaths for men and women in the United States, is preventable if precursor colonic lesions are detected and removed. Computed tomographic colonography (CTC), also known as virtual colonoscopy (VC), could substantially increase the capacity, safety, and patient compliance of colorectal examinations. CTC has been endorsed as a viable option for colorectal cancer screening by the recent guidelines of the American Cancer Society, U.S. Multi-Society Task Force, and the American College of Radiology. Laxative-free fecal-tagging CTC assisted by computer-aided detection (CAD) is an emerging CTC technique for eliminating of laxative agents or diarrhea-inducing high-osmolar contrast agents from bowel cleansing. A recent large-scale multi-center clinical trial suggests that the combination of laxative-free preparation with ingestion of oral contrast agent and CAD is feasible in making CTC examinations easy for patients to tolerate while detecting polyps e10 mm in size at sensitivity comparable to that of optical colonoscopy (OC). However, non-polypoid flat lesions and small polyps (6-9 mm in size) represent a significant source of false-negative studies. Thus the goal of this project is to develop a novel CAD scheme based on meCTC, denoted as a multi-energy CAD (meCAD) scheme, which overcomes the limitations of the CAD schemes based on single-energy CTC. We hypothesize that the meCAD scheme will (1) yield a high performance in the detection of both polypoid and non-polypoid colorectal lesions comparable to OC, and (2) improve radiologists' performance in the detection of clinically significant colorectal lesions in laxative free meCTC images at an ultra-low-dose. Our specific aims are (1) Establish a clinical ultra-low-dose meCTC image database for development and evaluation of a meCAD scheme; (2) Develop a novel meCAD scheme that effectively detects colorectal lesions in ultra-low-dose laxative-free meCTC images; (3) Evaluate clinical benefit of the meCAD scheme. Successful development and validation of the meCAD scheme will provide radiologists with an accurate and reliable non-invasive CTC screening scheme for early detection and diagnosis of colorectal lesions to prevent the occurrence of colorectal cancer.

描述（由申请人提供）：如果检测并去除前体结肠病变，可以预防结肠癌，是美国男性和女性癌症死亡的第二大原因。计算机断层扫描（CTC），也称为虚拟结肠镜检查（VC），可以大大提高结直肠检查的能力，安全性和患者依从性。美国癌症学会，美国多社会工作队和美国放射学院的最新指南对结直肠癌筛查的可行选择已被认可。由计算机辅助检测（CAD）辅助的无液压粪便标记CTC是一种新兴的CTC技术，用于消除从肠清洁中消除泻药或腹泻诱导的高渗透对比剂的腹泻剂。最近的一项大规模多中心临床试验表明，无泻药制剂与摄入口服造影剂和CAD的组合可以使患者易于耐受性CTC检查，同时易于检测息肉E10 mm，同时可与光学上的息肉相比（OC）。但是，非型扁平病变和小息肉（6-9毫米）代表了假阴性研究的重要来源。因此，该项目的目的是开发基于MECTC的新型CAD方案，称为多能CAD（MECAD）方案，该方案克服了基于单能CTC的CAD方案的局限性。我们假设MECAD方案将（1）在检测与OC相当的息肉样和非型型结肠直肠损伤时产生高性能，（2）在检测泻药中临床上显着的结直肠病变时提高了放射科医生的表现。 在超低剂量下游离MECTC图像。我们的具体目的是（1）建立一个临床超低剂量MECTC图像数据库，以开发和评估MECAD方案； （2）开发一种新型的MECAD方案，该方案有效地检测到无剂量泻药MECTC图像中的结直肠病变； （3）评估MECAD计划的临床益处。 MECAD方案的成功开发和验证将为放射科医生提供准确，可靠的非侵入性CTC筛查方案，用于早期检测和诊断结直肠病变，以防止发生结直肠癌的发生。