The SKyRoCKeT Study: Surface-Knit and Reformulate CADENCE-Kids for Translation.

SKyRoCKeT 研究：表面编织和重新设计 CADENCE-Kids 以进行翻译。

• 批准号: 10443934
• 负责人: Laura H Gunn
• 金额: $ 55.25万
• 依托单位: UNIVERSITY OF NORTH CAROLINA CHARLOTTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10443934
• 关键词: 20 year old; Academic achievement; Adolescent and Young Adult; Adult; Advisory Committees; Age; Algorithms; Behavior; Behavior Therapy; Body mass index; Caregivers; Characteristics; Child; Clinical; Cognition; Communication; Data; Development; Devices; Dimensions; Dose; Educational Curriculum; Energy Metabolism; Exertion; Funding; Guidelines; Health; Health education; Heart Rate; Height; Heterogeneity; Human; Indirect Calorimetry; Individual; Intervention; Leg; Length; Linear Models; Maximum Heart Rate; Measures; Metabolic; Modeling; Monitor; Obesity; Outcome; Oxygen; Oxygen Consumption; Parents; Persons; Physical Education; Physical activity; Physiological; Physiology; Pilot Projects; Preventive care; Protocols documentation; Public Health; Public Health Applications Research; Recommendation; Reporting; Research; Research Personnel; Risk Factors; Running; Sampling; Schools; Science; Strenuous Exercise; Surface; Time; Training; Translating; Translations; Walking; Weight; base; behavioral health intervention; cardiometabolic risk; cardiorespiratory fitness; cost; evidence base; flexibility; innovation; inter-individual variation; moderate-to-vigorous physical activity; personalized care; programs; recruit; response; sex; success; treadmill; uptake; user-friendly; vigorous intensity; wearable device

7. Project Summary/Abstract Physical activity (PA) is associated with a number of short- and long-term health outcomes in children, adolescents, and young adults (collectively, young people). In particular, an inverse dose-response relationship exists between moderate-to-vigorous PA (MVPA) and cardio-metabolic risk factors. Accurately quantifying young people’s daily MVPA is essential for effective surveillance, research, clinical, and public health applications. Yet, technical expressions of intensity in terms of energy expenditure (i.e., oxygen consumption or metabolic cost expressed in metabolic equivalents or METs) and/or percent of age-predicted heart rate maximum may be uninterpretable to all but those trained in human physiology. A more practically accessible yet still objective metric is needed to track and influence young people’s healthful levels of PA. The SKyRoCKeT Study (Surface-Knit and Reformulate CADENCE-Kids for Translation) will build on the R21 CADENCE-Kids study and recruit a sex- and age-balanced sample of 360 young people 6-20 years of age to: 1) Innovatively surface-‘knit’ the age dimension through a continuous, unbiased-by-age, and physiologically-coherent age-cadence-log(MET) flexible surface approach without artificially-generated jumps between age ranges and with enhanced precision of cadence-intensity threshold estimates. This single surface will coherently transition between ages, borrow inter-age information, and be data-driven; 2) Reformulate CADENCE-Kids by providing granular, age-specific cadence-intensity thresholds, calculated with enhanced precision for MVPA. Data will be objectively collected using a similar treadmill protocol to the R21-funded pilot study, with incrementally faster paces. A full running bout will now also be included for everyone when possible. We will concurrently collect cadence with direct observation as well as with multiple contemporary wearable technologies. Collecting cardio-respiratory fitness and habitual PA data, we will develop additional, innovative algorithms to predict relative intensity defined by lab-based indicators of oxygen uptake (%VO2peak, %VO2R), heart rate (%HRR, %HRmax), and rating of perceived exertion to facilitate computation of individually calibrated thresholds applicable to the free-living or habitual PA living condition. We will also investigate additional differences in surfaces and cadence-intensity thresholds by sex and body mass index standard deviation scores. Height- and/or leg-length-specific (hyper)surfaces will be explored as more precise alternatives to the age dimension; and 3) Propel science forward innovatively through translation to outdoor over-ground walking. We hypothesize that treadmill-set cadence-intensity thresholds will reliably translate and allow eliciting predictable metabolic costs during outdoor over-ground walking emblematic of free-living ambulatory behaviors. The SKyRoCKeT Study is an innovative critical step to provide coherent, interpretable, objectively monitored step-based intensity metrics of widespread use to inform national PA guidelines, interventions, assessments, analyses, school-based health education curricula and programs, and public health messages for young people.

7。项目摘要/摘要 体育活动（PA）与儿童的许多短期和长期健康结果有关， 青少年和年轻人（统称年轻人）。特别是剂量反应关系 现代对PA（MVPA）与心脏代谢风险因素之间存在。准确量化 年轻人的每日MVPA对于有效监视，研究，临床和公共卫生至关重要 申请。然而，在能源消耗方面的强度表达（即消耗氧 或代谢当量或Mets表达的代谢成本）和/或年龄预测的心率百分比 除了接受人类生理学训练的人以外，所有最多都可能无法解释。更实际访问 然而，需要客观的指标来跟踪和影响年轻人健康的PA水平。 飞速研究（表面编织和重差的循环 - kids进行翻译）将基于 R21 Cadence-kids研究和招募360名年轻人的性别和年龄均衡样本6 - 20年 年龄：1）创新地表面 - ''''年龄维度通过连续的，公正的年龄和 物理结合的年龄添加log（MET）柔性表面方法，而无需人工产生跳跃 在年龄范围内，并具有增强的节奏强度阈值估计值的精度。这个单个表面 将在年龄之间连贯过渡，借用年龄信息并被数据驱动； 2）重构 通过提供颗粒状，特定年龄的节奏强度阈值，可以通过增强来计算的刺激性。 MVPA的精度。数据将使用与R21资助的飞行员的类似跑步机协议客观地收集 研究，速度更快。现在，在可能的情况下也将包括全面的回合。 我们将同时收集直接观察以及多个现代可穿戴的节奏 技术。收集心脏呼吸的健身和习惯性PA数据，我们将开发其他创新性 预测通过基于实验室的氧气摄取指标（％vo2peak，％vo2r）定义的相对强度的算法， 心率（％HRR，％HRMAX）和感知的劳累等级以促进单独校准的计算 适用于自由生活或习惯性PA生活条件的阈值。我们还将调查其他 性别和体重指数标准偏差得分的表面和节奏强度阈值的差异。 高度 - 和/或腿长特异性（超级）表面将被探索为年龄的更精确的替代品 方面; 3）通过翻译到户外地面步行而创新的科学促进科学。我们 假设跑步机 - 循环 - 强度阈值将可靠地翻译并允许可预测 户外台面上的代谢成本象征着自由生活的卧床行为。 飞速研究是提供连贯，可解释，客观监控的创新关键步骤 基于步骤的强度指标宽度用于信息，以告知国家PA指南，干预措施，评估， 分析，基于学校的健康教育课程和课程，以及针对年轻人的公共卫生信息。