Systematic Light Exposure Intervention for Fatigue and Cognitive Efficiency in Pediatric Brain Tumor Survivors

系统性光照干预对小儿脑肿瘤幸存者的疲劳和认知效率

• 批准号: 10373350
• 负责人: HEATHER M CONKLIN
• 金额: $ 26.18万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373350
• 关键词: Academic achievement; Address; Adherence; Adolescent; Adolescent and Young Adult; Adult; Adverse effects; Affect; Age; Area; Attention; Biological Markers; Brain; Brain Neoplasms; Cancer Survivor; Child; Childhood; Childhood Brain Neoplasm; Circadian Rhythms; Cognition; Cognitive; Data; Detection; Diagnosis; Distress; Double-Blind Method; Drowsiness; Effectiveness; Emotional; Enrollment; Environment; Fatigue; Goals; Hormones; Household; Impairment; Income; Inflammatory; Intervention; Intervention Trial; Late Effects; Light; Literature; Malignant Neoplasms; Methods; Moods; Neurobehavioral Manifestations; Neurocognitive; Neurocognitive Deficit; Outcome; Parents; Participant; Patient Recruitments; Patients; Performance; Periodicity; Persons; Phase; Pilot Projects; Placebo Control; Placebos; Population; Populations at Risk; Proxy; Publishing; Quality of life; Randomized; Randomized Controlled Trials; Recording of previous events; Reporting; Research; Research Infrastructure; Risk; Self Management; Short-Term Memory; Sleep; Sleep Wake Cycle; Solid; Solid Neoplasm; Survival Rate; Survivors; Symptoms; Time; Treatment Efficacy; Treatment Side Effects; alertness; base; cancer therapy; circadian; cognitive benefits; cognitive function; cohort; computerized; cost; effective intervention; effectiveness evaluation; efficacy evaluation; experience; follow-up; functional outcomes; health related quality of life; hypothalamic pituitary axis; hypothalamic-pituitary-adrenal axis; improved; information processing; interest; memory process; multidisciplinary; patient population; poor sleep; post intervention; prevent; processing speed; programs; side effect; social; success; theories; treatment effect

PROJECT SUMMARY/ABSTRACT Due to advances in detection and treatment, there is a rapidly increasing population of survivors of pediatric brain tumor. With increased survival rates, there is greater emphasis on managing the late effects of pediatric brain tumor. Cognitive symptoms are prevalent among survivors and are associated with poor academic achievement, vocational success, and overall quality of life. However, few interventions have been trialed to reduce cognitive symptoms. To this end, fatigue is a common late effect of brain tumor and its treatment, and it significantly reduces cognitive efficiency, including attention and speed of processing information. Among survivors, interventions that are low cost, non-pharmacological, and appropriate for self-management are highly desired but rare. Systematic bright light exposure has been shown to be effective for improving sleep and reducing fatigue among adolescent and adult patient populations, including adolescent and young adult solid tumor, and adult cancer survivors. The purpose of the proposed study is to evaluate the feasibility and preliminary effectiveness of systematic bright light exposure for reducing fatigue and improving cognitive efficiency among pediatric brain tumor survivors. Forty survivors (ages 10-18 years) will be asked to wear systematic light exposure glasses for 30 minutes upon awakening for a six week period with follow-up at 2- weeks post-intervention. Systematic bright light exposure (intervention) will be compared to dim light exposure (placebo-control). As part of this study, we focus on intervention fidelity, using an integrated app recording timing and duration of light exposure; and adverse side effects associated with light exposure. We assess preliminary outcomes associated with patient and parent-proxy reports of fatigue and cognitive efficiency using in-person and remote administration of a computerized battery. The ultimate goal of this line of research is to trial interventions that mitigate cognitive late effects to improve quality of life in pediatric brain tumor survivors. Findings from this pilot study will be used to refine the intervention and inform a larger randomized controlled trial.

项目摘要/摘要 由于检测和治疗的进步，小儿幸存者人数迅速增加 脑肿瘤。随着存活率的提高，更加强调管理小儿的晚期作用 脑肿瘤。幸存者的认知症状普遍存在，并且学术差不良 成就，职业成功和整体生活质量。但是，很少有干预措施被试用 减少认知症状。为此，疲劳是脑肿瘤及其治疗的常见晚期作用，并且 显着降低了认知效率，包括注意力和处理信息的速度。之中 幸存者，低成本，非药理学和适合自我管理的干预措施是 高度期望但很少见。系统的明亮光线暴露已被证明可有效改善睡眠 并减少青少年和成年患者人群的疲劳，包括青少年和年轻人 实体瘤和成人癌症幸存者。拟议研究的目的是评估可行性和 系统的明亮光暴露于减轻疲劳和改善认知的初步有效性 小儿脑肿瘤幸存者的效率。将要求四十个幸存者（10-18岁）穿着 觉醒后，系统的光曝光眼镜持续了30分钟，六个星期，随访时间为2-- 干预后几周。将系统的明亮光线暴露（干预）与昏暗的光线曝光进行比较 （安慰剂控制）。作为这项研究的一部分，我们使用集成的应用记录专注于干预保真度 光线的时机和持续时间；和与光暴露有关的不利副作用。我们评估 与患者和父母有关疲劳和认知效率的患者和亲戚报告相关的初步结果 计算机电池的面对面和远程给药。这一研究的最终目标是 减轻认知后期影响以改善小儿脑肿瘤幸存者生活质量的试验干预措施。 该试点研究的发现将用于完善干预措施，并告知更大的随机控制 审判。