THE FUNCTIONAL ORGANIZATION OF AXONS

轴突的功能组织

• 批准号: 8363802
• 负责人: MATTHEW N RASBAND
• 金额: $ 0.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363802
• 关键词: Action Potentials; Axon; Epilepsy; Funding; Generations; Grant; Ion Channel; Mass Spectrum Analysis; Multiple Sclerosis; Myasthenia Gravis; National Center for Research Resources; Nervous system structure; Neurons; Neurotransmitter Receptor; Play; Principal Investigator; Proteins; Ranvier' s Nodes; Research; Research Infrastructure; Resources; Role; Schizophrenia; Signal Transduction; Site; Source; Spinal cord injury; United States National Institutes of Health; Work; cost; density; painful neuropathy; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The generation, propagation, and modulation of electrical signals in the nervous system require the precise subcellular localization of ion channels in neurons. For example, disrupted ion channel or neurotransmitter receptor distribution or density play important roles in neuropathic pain, spinal cord injury, schizophrenia, myasthenia gravis, epilepsy, and multiple sclerosis. Two of the best examples of ion channel/receptor clustering in the nervous system are found along axons at and near the node of Ranvier (nodes, paranodes, and juxtaparanodes) and the axon initial segment. Ion channels clustered at these sites play key roles in regulating action potential generation and propagation. However, very little is known about the mechanisms regulating localization and retention of proteins at the AIS and nodes of Ranvier. A major impediment to understanding how ion channels are clustered at axon initial segments and nodes of Ranvier is the relatively few numbers of proteins that have been identified at these sites. In this project, we will work to identify new components of nodes, paranodes, juxtaparanodes, and axon initial segments.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 神经系统中电信号的产生、传播和调制需要神经元中离子通道的精确亚细胞定位。 例如，离子通道或神经递质受体分布或密度的破坏在神经性疼痛、脊髓损伤、精神分裂症、重症肌无力、癫痫和多发性硬化症中发挥重要作用。 神经系统中离子通道/受体聚集的两个最佳例子是沿着朗飞结处及其附近的轴突（结节、旁节和并旁节）和轴突初始段发现的。 聚集在这些位点的离子通道在调节动作电位的产生和传播中发挥着关键作用。 然而，人们对调节 AIS 和 Ranvier 结蛋白定位和保留的机制知之甚少。 理解离子通道如何聚集在朗飞轴突初始段和节点的一个主要障碍是在这些位点鉴定的蛋白质数量相对较少。 在这个项目中，我们将努力识别节点、旁节点、并旁节点和轴突初始段的新组件。