Tuberculosis Research Institute at MUHAS

MUHAS 结核病研究所

• 批准号: 8707584
• 负责人: Charles Fordham von Reyn
• 金额: $ 27.21万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8707584
• 关键词: Adult; Advertising; Advisory Committees; African; Boston; Cause of Death; Childhood; Clinical; Complex; Development; Doctor' s Degree; Epidemiology; Ethics; Faculty; Funding; Good Clinical Practice; Grant; HIV; HIV Infections; Health Sciences; Immunology; Institutes; Laboratories; Leadership; Leprosy; Link; Master' s Degree; Measures; Mentors; Microbiology; Monitor; Performance; Persons; Pharmacology; Prevention; Public Health; Recruitment Activity; Research; Research Institute; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Secure; Students; TRIM Gene; Tanzania; Teleconferences; Training; Tuberculosis; Universities; base; clinical research site; experience; improved; pediatric human immunodeficiency virus; performance site; programs

DESCRIPTION (provided by applicant): Tuberculosis is the leading cause of death among persons with HIV infection in Tanzania. Clinical and operational research to improve prevention and treatment of both adult and pediatric HIV-TB is a defined national priority but there is no specifically designated and staffed institute to plan, coordinate and conduct such research. The objective of the Dartmouth-Boston University (DBU) application is to provide the training to develop a premier HIV-TB clinical and operational research institute: MUHAS leadership, the Tanzanian National Tuberculosis and Leprosy Program (NTLP) and former Fogarty trainees have all contributed to planning the new institute. The program will consolidate the expertise of past Fogarty trainees with a new focused plan to train the requisite professionals to fully staff TRIM-TB. The institute will be based a new office complex at MUHAS with additional staffing located at the NTLP. An initial faculty core at MUHAS (Director, Associate Director) will be augmented by the addition of trainees who will complete the following degrees determined to be necessary for providing the necessary research expertise for the institute: 3 MPH degrees at Dartmouth, 3 MPH degrees at MUHAS, 1 master's degree at BU (pharmacology) and 2 doctoral degrees at BU (epidemiology, public health). Additional short and medium term training in ethics, good clinical practice and HIV-TB research methods will be provided for investigators. Advanced TB microbiology and TB immunology training will be provided for research microbiologists who will staff the TRIM-TB core laboratory. Pilot grant funding will be available for HIV-TB research projects and investigators will coordinate efforts thru monthly research seminars at MUHAS linked by teleconference to Dartmouth and BU. Defined performance measures focused on development of independent HIV-TB research capacity have been developed and will be monitored. An extensive candidate pool will be recruited from health science students at MUHAS, prior DBU AITRP trainees, Fogarty alumni, public presentations and focused advertising. Performance sites for research will include adult and pediatric DarDar Programs, NTLP clinical sites, and the Fogarty African Consortium on Tuberculosis (FACT, developed by the DBU AITRP). Faculty for the program have extensive experience in HIV-TB research, actively funded research projects, and wide experience training and mentoring junior colleagues. An expert Training Advisory Committee will oversee the program. After 5 years TRIM-TB will have set HIV-TB research priorities for Tanzania and have secured independent funding for research on these priorities.

描述（由申请人提供）：结核病是坦桑尼亚艾滋病毒感染患者死亡的主要原因。临床和运营研究以改善成人和小儿艾滋病毒-TB的预防和治疗是一个定义的国家优先事项，但没有专门指定和人员的研究所来计划，协调和进行此类研究。达特茅斯波士顿大学（DBU）的应用程序的目的是提供培训，以开发一家高超的HIV-TB临床和运营研究所：Muhas领导力，坦桑尼亚国家结核病和麻风病和麻风病计划（NTLP）和前Fogarty受训者都为计划新学院提供了贡献。该计划将巩固过去的Fogarty培训生的专业知识，并制定一项新的计划，以培训必要的专业人员，以使TRIM-TB完全员工。该研究所将基于Muhas的一个新办公大楼，并在NTLP设有其他人员配备。穆哈斯（副主任，副主任）的最初教师核心将通过增加受训者的补充，他们将完成以下学位，确定为该研究所提供必要的研究专业知识：达特茅斯（Dartmouth）的必要研究专业知识，在达特茅斯（Dartmouth），MUHAS 3 MPH，在Muhas，Bu（BU（药理学）1 Mapter's Buctor Pocoral Hally和2 Bu Hally（epemi）（epemi）（epemi）（epedemi）（epemi）（epemi at epemi）（epedemi）（epedemi）。将为研究人员提供其他道德，良好临床实践和HIV-TB研究方法的其他短期和中期培训。将为TRIM-TB核心实验室人员配备的研究微生物学家提供先进的结核病微生物学和结核病免疫学培训。试点赠款资金将用于HIV-TB研究项目，调查人员将通过Muhas的每月研究研讨会进行协调，该研讨会通过电信与达特茅斯和BU联系。已经开发了针对独立HIV-TB研究能力发展的定义绩效指标，并将受到监控。将从Muhas的健康科学学生，先前的DBU AITRP受训者，Fogarty校友，公开演讲和集中广告的广告中招募一个广泛的候选池。研究的性能站点将包括成人和小儿达达计划，NTLP临床场所以及结核病的Fogarty African Consortium（事实，由DBU AITRP开发）。该计划的教师在HIV-TB研究，积极资助的研究项目以及广泛的经验培训和指导初级同事方面拥有丰富的经验。专家培训咨询委员会将监督该计划。 5年后，TRIM-TB将为坦桑尼亚设定HIV-TB研究的重点，并为这些优先级的研究获得了独立的资金。