Tuberculosis Research Institute at MUHAS

MUHAS 结核病研究所

• 批准号: 8514831
• 负责人: Charles Fordham von Reyn
• 金额: $ 27.46万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514831
• 关键词: Adult; Advertising; Advisory Committees; African; Boston; Cause of Death; Childhood; Clinical; Complex; Development; Doctor' s Degree; Epidemiology; Ethics; Faculty; Funding; Good Clinical Practice; Grant; HIV; HIV Infections; Health Sciences; Immunology; Institutes; Laboratories; Leadership; Leprosy; Link; Master' s Degree; Measures; Mentors; Microbiology; Monitor; Performance; Persons; Pharmacology; Prevention; Public Health; Recruitment Activity; Research; Research Institute; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Secure; Students; TRIM Gene; Tanzania; Teleconferences; Training; Tuberculosis; Universities; base; clinical research site; experience; improved; pediatric human immunodeficiency virus; performance site; programs

Tuberculosis is the leading cause of death among persons with HIV infection in Tanzania. Clinical and operational research to improve prevention and treatment of both adult and pediatric HIV-TB is a defined national priority but there is no specifically designated and staffed institute to plan, coordinate and conduct such research. The objective of the Dartmouth-Boston University (DBU) application is to provide the training to develop a premier HIV-TB clinical and operational research institute: the Tuberculosis Research Institute at Muhimibili University of Health and Allied Sciences (MUHAS) (TRIM- TB). MUHAS leadership, the Tanzanian National Tuberculosis and Leprosy Program (NTLP) and former Fogarty trainees have all contributed to planning the new institute. The program will consolidate the expertise of past Fogarty trainees with a new focused plan to train the requisite professionals to fully staff TRIM-TB. The institute will be based a new office complex at MUHAS with additional staffing located at the NTLP. An initial faculty core at MUHAS (Director, Associate Director) will be augmented by the addition of trainees who will complete the following degrees determined to be necessary for providing the necessary research expertise for the institute: 3 MPH degrees at Dartmouth, 3 MPH degrees at MUHAS, 1 master's degree at BU (pharmacology) and 2 doctoral degrees at BU (epidemiology, public health). Additional short and medium term training in ethics, good clinical practice and HIV-TB research methods will be provided for investigators. Advanced TB microbiology and TB immunology training will be provided for research microbiologists who will staff the TRIM-TB core laboratory. Pilot grant funding will be available for HIV-TB research projects and investigators will coordinate efforts thru monthly research seminars at MUHAS linked by teleconference to Dartmouth and BU. Defined performance measures focused on development of independent HIV-TB research capacity have been developed and will be monitored. An extensive candidate pool will be recruited from health science students at MUHAS, prior DBU AITRP trainees, Fogarty alumni, public presentations and focused advertising. Performance sites for research will include adult and pediatric DarDar Programs, NTLP clinical sites, and the Fogarty African Consortium on Tuberculosis (FACT, developed by the DBU AITRP). Faculty for the program have extensive experience in HIV-TB research, actively funded research projects, and wide experience training and mentoring junior colleagues. An expert Training Advisory Committee will oversee the program. After 5 years TRIM-TB will have set HIV-TB research priorities for Tanzania and have secured independent funding for research on these priorities.

结核病是坦桑尼亚艾滋病毒感染患者死亡的主要原因。临床和 改善成人和儿科HIV-TB的预防和治疗的运营研究是 定义的国家优先事项，但没有专门指定和人员进行计划，协调 并进行此类研究。达特茅斯波士顿大学（DBU）应用的目的是 提供培训以开发一家高超的HIV-TB临床和运营研究所： Muhimibili卫生与盟军科学大学（Muhas）的结核病研究所（Trim- TB）。 Muhas领导力，坦桑尼亚国家结核和麻风病计划（NTLP）和 前福加蒂学员都为计划新研究所做出了贡献。 该计划将巩固过去的Fogarty学员的专业知识，并制定新的计划，以培训 必要的专业人员，以便全职Trim-TB。该研究所将基于一个新的办公大楼 Muhas设有额外人员，位于NTLP。 Muhas的最初教师核心（主任， 副主任将通过增加以下学员的增加来增加 确定为为研究所提供必要的研究专业知识所必需的学位：3 达特茅斯（Dartmouth 2 BU博士学位（流行病学，公共卫生）。额外的短期和中期培训 将为研究人员提供伦理，良好的临床实践和HIV-TB研究方法。先进的 将为研究人员提供TB微生物学和结核病免疫学培训 TRIM-TB核心实验室。试点赠款资金将用于HIV-TB研究项目， 调查人员将通过TeleConconference连接的Muhas每月研究研讨会协调努力 到达特茅斯和bu。定义的绩效指标，重点是开发独立的HIV-TB 研究能力已经开发并将受到监控。 将从Muhas的健康科学专业的学生招募一个广泛的候选池 AITRP受训者，Fogarty校友，公开演讲和集中广告。性能站点 研究将包括成人和小儿戴尔塔尔计划，NTLP临床场所以及Fogarty African 结核病联盟（事实，由DBU AITRP开发）。该计划的教师 在HIV-TB研究，积极资助的研究项目和广泛的经验方面的丰富经验 培训和指导初级同事。专家培训咨询委员会将监督 程序。 5年后，TRIM-TB将为坦桑尼亚设定HIV-TB的研究重点 获得了有关这些优先事项的独立资助。