Neural Coding of 3D Object and Place Structure in Two Cortical Pathways

两条皮质通路中 3D 物体和位置结构的神经编码

• 批准号: 8612222
• 负责人: CHARLES E CONNOR
• 金额: $ 32.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8612222
• 关键词: Agnosia; Area; Biological; Blindness; Brain; Brain imaging; Cells; Characteristics; Code; Complement; Complex; Computer Simulation; Data; Data Set; Diagnostic; Elements; Face; Force of Gravity; Functional Imaging; Future; Genetic Programming; Homologous Gene; Human; Individual; Investigation; Lead; Maps; Measures; Medial; Memory; Metric; Modeling; Monkeys; Movement; Neurons; Pathway interactions; Patients; Perception; Positioning Attribute; Process; Prosthesis; Rehabilitation therapy; Relative (related person); Research; Role; Sampling; Shapes; Staging; Stimulus; Stream; Stroke; Structure; Surface; Three-dimensional analysis; Vision; Visual; Visual Cortex; Visual Pathways; Visual Perception; base; brain pathway; comparative; computerized; eye center; mathematical analysis; mathematical model; novel; public health relevance; relating to nervous system; response; statistics; three dimensional structure; visual information; visual process; visual processing

Project summary The LONG-TERM GOAL of this project is to understand how the brain processes visual information about places-landscapes and interiors-and how that compares to brain processing of visual information about objects. We will measure object- and place-related responses of neurons in higher processing stages within two major brain pathways: (1) The ventral visual pathway is traditionally considered to be an object pathway, but our preliminary data show that it is also strongly engaged in representation of landscapes and interiors, with a dorsolateral-ventromedial gradient from object-related processing to place-related processing. (2) The recently recognized parieto-medial temporal pathway primarily processes place information and terminates in parahippocampal cortex. We will use mathematical analysis to understand how object and place information is encoded by neurons in these two pathways. We expect the results to have the following scientific impacts: 1. This first analysis of complex place shape is encoded at the level of individual neurons and groups of neurons will deepen understanding of brain mechanisms for perceiving, understanding, interacting with, and navigating through landscapes and interiors, complementing previous research at the brain imaging level. 2. Analytical comparison will elucidate how coding mechanisms are specialized for the very different structural characteristics and ecological roles of objects and places. 3. Analytical comparison of shape coding mechanisms between the ventral and parieto-medial pathways will increase understanding of how different visual functions are distributed across the brain. 4. Combined study of object and place coding will lead to future research on how these two elements combine in overall perception of visual scenes.

项目摘要 该项目的长期目标是了解大脑如何处理有关的视觉信息 地点景观和室内装饰以及如何将其与大脑处理的视觉信息进行比较 对象。我们将在更高的处理阶段中测量神经元与对象和位置相关的响应 两个主要的大脑通道：（1）传统上认为腹侧视觉通路是对象途径， 但是我们的初步数据表明，它也强烈参与了景观和内饰的代表， 从与对象相关的处理到与位置相关的处理，具有背外侧通态梯度。 （2） 最近公认的壁层中间时间途径主要处理信息并终止 Parahampocampal皮层。我们将使用数学分析来了解对象和放置信息的方式 在这两个途径中由神经元编码。我们预计结果将产生以下科学影响： 1。对复杂位置形状的首次分析是在单个神经元和组级别编码的 神经元将加深对大脑机制的理解，以感知，理解，与之互动和 通过景观和内部导航，补充了先前的大脑成像水平研究。 2。分析比较将阐明编码机制如何专门针对非常不同的结构 物体和地方的特征和生态作用。 3。腹侧和壁层中途径之间形状编码机制的分析比较 增加对不同视觉功能如何在大脑中分布的理解。 4。对物体和地点编码的合并研究将导致对这两个元素的结合方式的未来研究 在视觉场景的整体感知中。