Requirement for Sensitive T Cell Response to Antigen

T 细胞对抗原作出敏感反应的要求

• 批准号: 8673645
• 负责人: Michael Loran Dustin
• 金额: $ 14万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-28 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8673645
• 关键词: Actins; Adhesions; Agonist; Antigen-Presenting Cells; Antigens; Attention; Autoimmunity; CD28 gene; CD4 Positive T Lymphocytes; CD80 gene; Cell Adhesion Molecules; Cell Culture Techniques; Chills; Complex; Cytoplasmic Tail; Distal; Emergency Situation; Equilibrium; Funding; GRP gene; Hour; IL2RA gene; Immune response; Institutes; Intercellular adhesion molecule 1; Lateral; Ligands; Location; MHC Class II Genes; Mediator of activation protein; Membrane; Microfilaments; NF-kappa B; Nonmuscle Myosin Type IIA; Palmitic Acylation Site; Pathway interactions; Peptide/MHC Complex; Peripheral; Physiological; Process; Publications; Reagent; Regulatory T-Lymphocyte; Resolution; Role; Signal Pathway; Signal Transduction; Site; Son of Sevenless Proteins; Structure; T cell response; T-Cell Activation; T-Lymphocyte; TSG101 gene; Transcription Factor AP-1; Viral Tumor Antigens; Water; Work; cell motility; immunological synapse; latrunculin A; mimetics; pathogen; polymerization; research study; response; signal processing; single molecule

There were two types of setbacks to this R37 project. Lab staff lost 2 months of work as will be explained and material were destroyed in cold rooms and some refrigerators that failed due to insufficient emergency power early in the outage and loss of the chilled water. The full closure of the Skirball Institute for over 2 weeks caused a disruption of work that resulted in loss of experiments started up on 2 weeks prior to the storm on Oct 29 and required an additional month to fully recover cell cultures and reagents to resume experiments by mid December 2012.

R37 项目遇到了两种挫折。实验室工作人员因此失去了两个月的工作 将进行解释，并且材料在冷藏室和一些冰箱中被销毁 由于停电初期应急电源不足和冷藏丢失而失败 水。斯基博尔研究所全面关闭两周多，造成了 导致 10 月风暴前 2 周开始的实验失败的工作 29 并需要额外一个月的时间才能完全恢复细胞培养物和试剂 2012 年 12 月中旬恢复实验。