Immunoreceptors

免疫受体

• 批准号: 7539017
• 负责人: Michael Loran Dustin
• 金额: $ 1.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7539017
• 关键词: Antibodies; Area; Arts; Autoimmune Diseases; Autoimmunity; Biology; Cell Surface Receptors; Cell surface; Cells; Clinic; Clinical; Discipline; Disease; Down-Regulation; Equilibrium; Family; Fc Receptor; Female; Fertilization; Goals; Immune system; Immunoglobulin Constant Region; Immunoglobulins; Inflammation; Malignant Neoplasms; Membrane; Minority; Molecular Structure; Research; Role; Scientist; Series; Signal Transduction; Structure; Structure-Activity Relationship; Surface; Therapeutic; Translational Research; Underrepresented Minority; United States National Institutes of Health; Woman; abstracting; age group; base; immunological synapse; interest; intermolecular interaction; receptor; receptor function; receptor structure function; symposium; therapeutic target; translational study

DESCRIPTION (provided by applicant): Cell surface receptors of the immune system (immunoreceptors) have proven to be very effective therapeutic targets in a variety of clinical settings including cancer and autoimmune disease. For example effective antibody based biologicals targeted to immunoreceptors may act by receptor antagonism, down-regulation and/or targeting of receptor bearing cells for destruction by the innate immune system. To reach the full potential of this approach a more complete understanding or cell surface receptor structure-function relationships and signaling will be necessary. The progress toward this goal can be attained most rapidly when interactions among clinicians and scientists are maximized by focused conferences. We apply for NIH support for the 2008 FASEB conference on "Immunoreceptors" to be held in New Haven, CT, August 3-8, 2008. The conference evolved from a series of successful conferences held bi-annually since the early 1980's that originally focused on the question of immunoglobulin constant region (Fc) receptor function. In recent iterations, the scope of the meeting has broadened to consider function of other immune system receptors that contain Ig-folds. The conference will bring together experts who, although they come from different disciplines, share interests in this family of receptors including: molecular structure and how it informs function, the role of these receptors in inflammation, signal transduction and exploitation in the clinic. Goals of the conference include fertilization across these disciplines and involvement of young, female and minority scientists in these research areas. Thus among the invited 26 speakers confirmed thus far 5 are women and an additional 9 presentations will be solicited from young scientists who submit abstracts. Major themes will be 1) molecular structure-function, 2) membrane domains, 3) intermolecular interactions and proximal signaling, 4) immunological synapse, 5) the role of immunoreceptors in diseases and 6) therapeutic application in inflammation, autoimmunity and cancer. The conference is structured to provide an optimal opportunity for cross-discipline interaction as well as a balanced presentation of state of the art information on the most contemporary topics and contentious problems in our field. It is intended to nurture translational studies to develop therapeutic compounds targeted to cell surface molecules. The FASEB conference on "Immunoreceptors" will be held in New Haven CT between August 3-8, 2008. The conference will focus on contemporary problems in the structure, function, biology and therapeutic applications of immunoglobulin related surface receptors of the immune system. The conference will bring together 120-150 diverse scientists including all age groups, women and underrepresented minorities to stimulate basic and translational research at the leading edge of this area.

描述（由申请人提供）： 在包括癌症和自身免疫性疾病在内的各种临床环境中，免疫系统的细胞表面受体（免疫受体）已被证明是非常有效的治疗靶标。例如，针对免疫感受器的有效基于抗体的生物学物质可以通过受体拮抗作用，下调和/或靶向受体轴承细胞来破坏先天免疫系统。为了达到这种方法的全部潜力，将需要更完整的理解或细胞表面受体结构功能关系和信号传导。当临床医生和科学家之间的相互作用被集中的会议最大化时，可以最快地实现这一目标的进展。我们向2008年8月3日至8日在康涅狄格州纽黑文举行的2008年FASEB大会“免疫感受器”会议申请NIH支持。这次会议是自1980年代初期两年一次的一系列成功会议演变而来的，该会议最初集中在最初介绍免疫球蛋白恒定区域（FC）受体函数的问题上。在最近的迭代中，会议的范围扩大了考虑包含Ig折叠的其他免疫系统受体的功能。该会议将汇集专家，尽管他们来自不同的学科，但他们对这个受体家族有兴趣，包括：分子结构及其如何为功能提供信息，这些受体在诊所中炎症，信号转导和剥削中的作用。会议的目标包括在这些学科中受精以及这些研究领域的年轻，女性和少数族裔科学家的参与。因此，在迄今为止有5名女性确认的26位发言人中，有9个演讲将从提交摘要的年轻科学家那里征求来。主要主题将是1）分子结构功能，2）膜结构域，3）分子间相互作用和近端信号传导，4）免疫突触，5）免疫受体在疾病中的作用和6）在炎症，自身免疫性和癌症中的治疗应用。该会议的结构是为跨学科互动提供最佳机会，以及关于我们领域最现代的主题和有争议问题的最新信息的平衡介绍。它旨在培养转化研究以开发针对细胞表面分子的治疗化合物。 FASEB关于“免疫感受器”会议将在2008年8月3日至8日之间在纽黑文CT举行。会议将重点介绍免疫系统中与免疫球蛋白相关的表面受体的结构，功能，生物学和治疗应用中的当代问题。该会议将汇集120-150个不同的科学家，包括所有年龄段，妇女和代表性不足的少数民族，以刺激该领域的前沿基础和转化研究。