Environmental Control of the Immunological Synapse

免疫突触的环境控制

• 批准号: 8673598
• 负责人: Michael Loran Dustin
• 金额: $ 6.03万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-24 至 2014-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8673598
• 关键词: Antigen-Presenting Cells; Antigens; Bypass; CCL19 gene; CCL21 gene; Cell Communication; Cell Culture Techniques; Cell surface; Complex; Data; Electron Microscopy; Emergency Situation; Eragrostis; Event; Failure; Frequencies; Generations; Hour; In Vitro; Inflammatory; Institutes; Intestines; Ligands; Ligation; Location; Mediating; Movement; Pathway interactions; Peptide/MHC Complex; Peripheral; Reagent; Regulation; Regulatory T-Lymphocyte; Series; Signal Transduction; Site; Synapses; T-Cell Activation; T-Lymphocyte; Testing; Time; Tissues; Viral Tumor Antigens; Work; anergy; base; chemokine; chemokine receptor; dosage; immunological synapse; in vivo; light microscopy; lymph nodes; migration; receptor; research study; synaptic inhibition; synaptogenesis

There were two types of setbacks to this R01 project. Lab staff lost 2 months of work as will be explained and material were destroyed in cold rooms and some refrigerators that failed due to insufficient emergency power early in the outage. The full closure of the Skirball Institute for 2 weeks caused a disruption of work that resulted in loss of experiments started up on 2 weeks prior to the storm on Oct 29 and required an additional month to fully recover cell cultures and reagents to resume experiments.

这个R01项目有两种类型的挫折。实验室工作人员失去了2个月的工作 将被解释，并在寒冷的房间和一些冰箱中销毁材料 由于停电早期的紧急功率不足而失败。完全关闭 Skirball Institute持续了2周，导致工作中断，导致失去 实验从10月29日暴风雨前2周开始，需要 额外的月份以充分恢复细胞培养物和试剂以恢复实验。