Environmental Control of the Immunological Synapse

免疫突触的环境控制

• 批准号: 8673598
• 负责人: Michael Loran Dustin
• 金额: $ 6.03万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-24 至 2014-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8673598
• 关键词: Antigen-Presenting Cells; Antigens; Bypass; CCL19 gene; CCL21 gene; Cell Communication; Cell Culture Techniques; Cell surface; Complex; Data; Electron Microscopy; Emergency Situation; Eragrostis; Event; Failure; Frequencies; Generations; Hour; In Vitro; Inflammatory; Institutes; Intestines; Ligands; Ligation; Location; Mediating; Movement; Pathway interactions; Peptide/MHC Complex; Peripheral; Reagent; Regulation; Regulatory T-Lymphocyte; Series; Signal Transduction; Site; Synapses; T-Cell Activation; T-Lymphocyte; Testing; Time; Tissues; Viral Tumor Antigens; Work; anergy; base; chemokine; chemokine receptor; dosage; immunological synapse; in vivo; light microscopy; lymph nodes; migration; receptor; research study; synaptic inhibition; synaptogenesis

There were two types of setbacks to this R01 project. Lab staff lost 2 months of work as will be explained and material were destroyed in cold rooms and some refrigerators that failed due to insufficient emergency power early in the outage. The full closure of the Skirball Institute for 2 weeks caused a disruption of work that resulted in loss of experiments started up on 2 weeks prior to the storm on Oct 29 and required an additional month to fully recover cell cultures and reagents to resume experiments.

R01 项目遇到了两种挫折。实验室工作人员因此失去了两个月的工作 将进行解释，并且材料在冷藏室和一些冰箱中被销毁 由于停电初期应急电源不足而失败。全面关闭 斯基博尔研究所 (Skirball Institute) 两周造成工作中断，导致人员流失 实验在 10 月 29 日风暴发生前两周开始，需要 额外一个月的时间来完全恢复细胞培养物和试剂以恢复实验。