Health Sciences Center Animal Resource Facility Improvement

健康科学中心动物资源设施改善

• 批准号: 8712910
• 负责人: Kevin C O'Hair
• 金额: $ 49.1万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712910
• 关键词: Accreditation; Affect; Air; Anesthesia procedures; Anesthetic Gases; Animals; Area; Award; Behavioral; Behavioral Research; Biomedical Research; Boxing; Brain; Breeding; Cancer Center; Cardiovascular Diseases; Censuses; Center for Translational Science Activities; Child health care; Clinical; Clinical Sciences; Communicable Diseases; Community Health Centers; Development; Duct (organ) structure; Environmental Health; Environmental air flow; Equipment; Excision; Faculty; Female; Floor; Gases; Goals; Health Sciences; House mice; Housing; Image; Immunity; Immunology; Individual; Inhalant dose form; Isoflurane; Laboratories; Malignant Neoplasms; Mechanics; Medical; Metabolic Diseases; Metabolism; Mus; Neurosciences; New Mexico; Obesity; Oxygen; Particulate; Patient Care; Pharmacy facility; Procedures; Request for Proposals; Research; Research Design; Research Personnel; Rest; Safety; Sanitation; Science; Secure; Side; Site; Specific Pathogen Frees; Stainless Steel; Technology; United States National Institutes of Health; Universities; Water; animal care; animal facility; animal resource; anticancer research; balance testing; college; cost; exhaust; falls; foot; germ free condition; high efficiency particulate air filter; improved; medical schools; meetings; member; mouse model; programs; research facility; wasting

DESCRIPTION (provided by applicant): The aim of this G20 proposal entitled "UNM Health Sciences Center Animal Resource Facility Improvement" is a request for $499,967 to: 1) support purchase of 25 ventilated mouse racks with cages/accessories and associated mechanical and electrical construction to provide connection of these units to building exhaust and electrical in four of the five SPF mouse rooms (the 5th room is in the mouse breeding barrier and connections were installed during a recent renovation) (1261 gsf / 1159 nsf). 2) To upgrade 2 procedures rooms (399 gsf / 352 nsf) in the SPF mouse research suite to remove old and add new casework and purchase a 5 foot HEPA filtered animal procedure station to be located in one of the procedure rooms. The total space affected by this project is 1,660 gsf / 1,511 nsf, and it includes space where equipment is sited and/or renovation at the University of New Mexico (UNM) Health Sciences Center (HSC) Animal Resource Facility (ARF). This ARF project is located in contiguous space within the Biomedical Research Facility (BRF) and the Basic Medical Sciences Building (BMSB). The BRF/BMSB animal facilities comprise the major component of ARF but the HSC ARF also includes housing/research in two HSC satellite imaging facilities. This project builds upon improvements from three previous renovation projects completed in the BRF and BMSB ARF in 2002 and 2008, and 2013. These past renovations upgraded mechanical (HVAC with DDC controls and environmental alarms), floors, finishes and roofing and the most recent project (2012 G20 award $500K plus $82K institutional match) replaced a 26 year old tunnel washer, renovated 4 rooms and added 16 ventilated mouse racks to 3 of the 4 rooms in the mouse breeding barrier. This new proposed project will add five ventilated mouse racks to the remaining room in the mouse breeding barrier (barrier supports 19 PI laboratories) that will be purchased with the large cages (180 in2/cage - 36 cages/rack) that can be used in any rack in the breeding barrier by interchanging with small cages (75 in2/cage) (2 small cages fit in the slot for 1 large cage). We propose the large cages in the breeding barrier to allow us to support trio breeding with adequate space per breeding female recommended under the 8th edition NIH guide. Second we propose to renovate and add 20 ventilated racks (5 racks/room) in the 4 mouse rooms in the specific pathogen free (SPF) research suite. These proposed ventilated racks are single sided units with capacity of 72 cages (75 in2 /cage) per unit. This rack format will allow us to increase room cage capacity by 25% (288 to 360 cages). This SPF mouse research suite currently supports 41 PI laboratories. These rooms are currently near capacity and 3 new faculty with mouse research programs plan to transfer their mice to the ARF by January 2014. Two of the 3 faculty are members of the Cancer Center and our goal is to co-locate them with the rest of our mouse cancer research users. This project will increase capacity in this suite to support this goal. The two procedure rooms in the SPF mouse research suite currently have central oxygen gases and inhalant isoflurane anesthesia units with waste anesthetic gas scavenging provided through our building exhaust. One of the rooms has a Class II A2 Biosafety Cabinet that provides protection to the mice from potential microbiological contamination and operator safety (particulate only). The casework in one of the rooms is wooden and the quantity and format of the casework in both rooms is insufficient to support our users in this suite. Therefore, we propose to upgrade casework in the two procedure rooms to improve functionality with segregated secure equipment storage, add a new sink with the casework in one of the procedure rooms and add a mobile HEPA filter procedure station. In general, this project is a continuation to transition from static microisolatr mouse cages to ventilated cages. Completion of the project is critical for us to continue meeting our strategic and programmatic goals which are to: expand a productive partnership between the NIH and UNM HSC; enhance our support to the HSC Signature Programs (Brain and Behavioral Illnesses, Cancer, Cardiovascular and Metabolic Disease, Child Health, Environmental He0alth, and Infectious Diseases and Immunity); expand development of new emerging synergies with ARF as one of the technology cores within our Clinical and Translational Science Center Award (CTSC); improve animal care compliance; and sustain AAALAC accreditation which HSC has continued since 1973. New equipment under this project will improve animal care by improving animal room and cage air quality with ventilation of the cages and exhaust from the building and enhance UNM'S sustainability goals by saving energy and water (less frequent cage changing/sanitation). The cost of labor and cage supplies will also be reduced which will lower cost escalation to core users. In conclusion, we continually seek ways to accelerate the pace of discoveries through our interdisciplinary CTSC which has overarching goals to promote a healthier public and more affordable patient care.

描述（由申请人提供）：该G20提案的目的为“ UNM Health Sciences Center Animal Resource Resource Antire设施改善”的要求是$ 499,967 to：1）支持购买25个通风的鼠标架，并提供了带有笼子/配件的机械机械和电气构造，以提供这些单位的连接，以便在五个SPF鼠标中建立五个SPF鼠标的连接，并在五个SPF鼠标中进行连接（翻新）（1261 GSF / 1159 NSF）。 2）在SPF鼠标研究套件中升级2个程序室（399 GSF / 352 NSF），以删除旧案例并添加新的案例工作，并购买一个5英尺的HEPA过滤动物程序站，位于其中一个程序室中。该项目影响的总空间为1,660 GSF / 1,511 NSF，其中包括设备位置和 /或在新墨西哥大学（UNM）健康科学中心（HSC）动物资源设施（ARF）的空间。该ARF项目位于生物医学研究设施（BRF）和基本医学大楼（BMSB）内的连续空间中。 BRF/BMSB动物设施构成了ARF的主要组成部分，但HSC ARF还包括两个HSC卫星成像设施中的住房/研究。 This project builds upon improvements from three previous renovation projects completed in the BRF and BMSB ARF in 2002 and 2008, and 2013. These past renovations upgraded mechanical (HVAC with DDC controls and environmental alarms), floors, finishes and roofing and the most recent project (2012 G20 award $500K plus $82K institutional match) replaced a 26 year old tunnel washer, renovated 4 rooms and added 16在小鼠繁殖屏障中的4个房间中的3个房间中的3个房间中通风。这个新提出的项目将在鼠标繁殖屏障的其余房间（屏障支撑19个PI实验室）中增加五个通风的鼠标架，它们将与大笼子（180 in2/cage -36架-36个笼子/机架）一起购买，这些架子可在任何架子中使用，这些架子可通过与小笼子（75 In2/cage fit for 2 in cage）（2小cage）（2小cage）（2个小锅）使用。我们提出了繁殖屏障中的大笼子，使我们能够在第8版NIH指南下推荐的每个育种女性提供足够的空间。其次，我们建议在特定的无病原体（SPF）研究套件中的4个小鼠房间中进行翻新并添加20个通风架（5个架子/房间）。这些提议的通风架是单侧单元，其容量为72个笼子（75 in2 /cage）。这种机架格式将使我们能够将房间笼的容量提高25％（288至360个笼子）。该SPF小鼠研究套件目前支持41个PI实验室。这些房间目前已经接近容量，有3个新教师与老鼠研究计划计划在2014年1月之前将其小鼠转移到ARF。这3个教职员工中有两个是癌症中心的成员，我们的目标是与我们的其他老鼠癌症研究使用者共同安置它们。该项目将增加此套件的能力以支持这一目标。 SPF小鼠研究套件中的两个程序室目前具有中央氧气和吸入的异氟烷麻醉单元，并通过我们的建筑物排气提供了废麻醉气体清除。其中一个房间设有II类A2生物安全柜，可为小鼠提供保护，免受潜在的微生物污染和操作员安全性（仅颗粒）。其中一个房间的案例是木制的，两个房间中案例的数量和格式不足以支持我们的用户在此套房中。因此，我们建议在两个过程室中升级案例工作，以通过隔离的安全设备存储来提高功能，在其中一个过程室中添加一个新的水槽，并添加一个移动的HEPA滤波器程序站。通常，该项目是从静态微溶解小鼠笼子过渡到通风笼。该项目的完成对于我们继续实现我们的战略和程序化目标至关重要，这些目标将在：扩大NIH和UNM HSC之间的富有成效的伙伴关系；增强我们对HSC签名计划的支持（大脑和行为疾病，癌症，心血管和代谢疾病，儿童健康，环境HE0ALTH以及传染病和免疫力）；扩大与ARF新兴协同作用的开发，是我们临床和转化科学中心奖（CTSC）中的技术核心之一；改善动物护理依从性；并维持HSC自1973年以来继续进行的AAAALAC认证。该项目下的新设备将通过改善动物室和笼子空气质量来改善动物护理，并通过笼子和建筑物的排气进行通风，并通过节省能源和水来增强UNM的可持续性目标（较少频繁的笼子更换/卫生设施）。人工和笼子供应的成本也将减少，这将降低成本上升到核心用户。总之，我们不断寻求通过跨学科CTSC加速发现速度的方法，该跨学科CTSC具有总体目标，可以促进更健康的公众和更负担得起的患者护理。