Health Sciences Center Animal Resource Facility Improvement

健康科学中心动物资源设施改善

• 批准号: 8712910
• 负责人: Kevin C O'Hair
• 金额: $ 49.1万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712910
• 关键词: Accreditation; Affect; Air; Anesthesia procedures; Anesthetic Gases; Animals; Area; Award; Behavioral; Behavioral Research; Biomedical Research; Boxing; Brain; Breeding; Cancer Center; Cardiovascular Diseases; Censuses; Center for Translational Science Activities; Child health care; Clinical; Clinical Sciences; Communicable Diseases; Community Health Centers; Development; Duct (organ) structure; Environmental Health; Environmental air flow; Equipment; Excision; Faculty; Female; Floor; Gases; Goals; Health Sciences; House mice; Housing; Image; Immunity; Immunology; Individual; Inhalant dose form; Isoflurane; Laboratories; Malignant Neoplasms; Mechanics; Medical; Metabolic Diseases; Metabolism; Mus; Neurosciences; New Mexico; Obesity; Oxygen; Particulate; Patient Care; Pharmacy facility; Procedures; Request for Proposals; Research; Research Design; Research Personnel; Rest; Safety; Sanitation; Science; Secure; Side; Site; Specific Pathogen Frees; Stainless Steel; Technology; United States National Institutes of Health; Universities; Water; animal care; animal facility; animal resource; anticancer research; balance testing; college; cost; exhaust; falls; foot; germ free condition; high efficiency particulate air filter; improved; medical schools; meetings; member; mouse model; programs; research facility; wasting

DESCRIPTION (provided by applicant): The aim of this G20 proposal entitled "UNM Health Sciences Center Animal Resource Facility Improvement" is a request for $499,967 to: 1) support purchase of 25 ventilated mouse racks with cages/accessories and associated mechanical and electrical construction to provide connection of these units to building exhaust and electrical in four of the five SPF mouse rooms (the 5th room is in the mouse breeding barrier and connections were installed during a recent renovation) (1261 gsf / 1159 nsf). 2) To upgrade 2 procedures rooms (399 gsf / 352 nsf) in the SPF mouse research suite to remove old and add new casework and purchase a 5 foot HEPA filtered animal procedure station to be located in one of the procedure rooms. The total space affected by this project is 1,660 gsf / 1,511 nsf, and it includes space where equipment is sited and/or renovation at the University of New Mexico (UNM) Health Sciences Center (HSC) Animal Resource Facility (ARF). This ARF project is located in contiguous space within the Biomedical Research Facility (BRF) and the Basic Medical Sciences Building (BMSB). The BRF/BMSB animal facilities comprise the major component of ARF but the HSC ARF also includes housing/research in two HSC satellite imaging facilities. This project builds upon improvements from three previous renovation projects completed in the BRF and BMSB ARF in 2002 and 2008, and 2013. These past renovations upgraded mechanical (HVAC with DDC controls and environmental alarms), floors, finishes and roofing and the most recent project (2012 G20 award $500K plus $82K institutional match) replaced a 26 year old tunnel washer, renovated 4 rooms and added 16 ventilated mouse racks to 3 of the 4 rooms in the mouse breeding barrier. This new proposed project will add five ventilated mouse racks to the remaining room in the mouse breeding barrier (barrier supports 19 PI laboratories) that will be purchased with the large cages (180 in2/cage - 36 cages/rack) that can be used in any rack in the breeding barrier by interchanging with small cages (75 in2/cage) (2 small cages fit in the slot for 1 large cage). We propose the large cages in the breeding barrier to allow us to support trio breeding with adequate space per breeding female recommended under the 8th edition NIH guide. Second we propose to renovate and add 20 ventilated racks (5 racks/room) in the 4 mouse rooms in the specific pathogen free (SPF) research suite. These proposed ventilated racks are single sided units with capacity of 72 cages (75 in2 /cage) per unit. This rack format will allow us to increase room cage capacity by 25% (288 to 360 cages). This SPF mouse research suite currently supports 41 PI laboratories. These rooms are currently near capacity and 3 new faculty with mouse research programs plan to transfer their mice to the ARF by January 2014. Two of the 3 faculty are members of the Cancer Center and our goal is to co-locate them with the rest of our mouse cancer research users. This project will increase capacity in this suite to support this goal. The two procedure rooms in the SPF mouse research suite currently have central oxygen gases and inhalant isoflurane anesthesia units with waste anesthetic gas scavenging provided through our building exhaust. One of the rooms has a Class II A2 Biosafety Cabinet that provides protection to the mice from potential microbiological contamination and operator safety (particulate only). The casework in one of the rooms is wooden and the quantity and format of the casework in both rooms is insufficient to support our users in this suite. Therefore, we propose to upgrade casework in the two procedure rooms to improve functionality with segregated secure equipment storage, add a new sink with the casework in one of the procedure rooms and add a mobile HEPA filter procedure station. In general, this project is a continuation to transition from static microisolatr mouse cages to ventilated cages. Completion of the project is critical for us to continue meeting our strategic and programmatic goals which are to: expand a productive partnership between the NIH and UNM HSC; enhance our support to the HSC Signature Programs (Brain and Behavioral Illnesses, Cancer, Cardiovascular and Metabolic Disease, Child Health, Environmental He0alth, and Infectious Diseases and Immunity); expand development of new emerging synergies with ARF as one of the technology cores within our Clinical and Translational Science Center Award (CTSC); improve animal care compliance; and sustain AAALAC accreditation which HSC has continued since 1973. New equipment under this project will improve animal care by improving animal room and cage air quality with ventilation of the cages and exhaust from the building and enhance UNM'S sustainability goals by saving energy and water (less frequent cage changing/sanitation). The cost of labor and cage supplies will also be reduced which will lower cost escalation to core users. In conclusion, we continually seek ways to accelerate the pace of discoveries through our interdisciplinary CTSC which has overarching goals to promote a healthier public and more affordable patient care.

描述（由申请人提供）：这项题为“新墨西哥大学健康科学中心动物资源设施改进”的 G20 提案的目的是请求 499,967 美元，以： 1) 支持购买 25 个带笼子/配件的通风鼠标架以及相关的机械和电气结构为五个 SPF 小鼠室中的四个提供这些装置与建筑排气和电力的连接（第五个房间位于小鼠繁殖屏障内，连接是在最近的翻修过程中安装的） （1261 gsf / 1159 nsf）。 2) 升级 SPF 小鼠研究套件中的 2 个手术室（399 gsf / 352 nsf），以拆除旧的并添加新的案例，并购买位于其中一间手术室的 5 英尺 HEPA 过滤动物手术站。受该项目影响的总空间为 1,660 gsf / 1,511 nsf，其中包括新墨西哥大学 (UNM) 健康科学中心 (HSC) 动物资源设施 (ARF) 的设备放置和/或翻新空间。该 ARF 项目位于生物医学研究设施 (BRF) 和基础医学科学大楼 (BMSB) 内的连续空间。 BRF/BMSB 动物设施是 ARF 的主要组成部分，但 HSC ARF 还包括两个 HSC 卫星成像设施的住房/研究。该项目以 2002 年、2008 年和 2013 年在 BRF 和 BMSB ARF 完成的三个改造项目为基础进行改进。过去的这些改造升级了机械（带 DDC 控制和环境警报的 HVAC）、地板、饰面和屋顶以及最近的项目（2012 G20 奖金 50 万美元加 8.2 万美元机构配套）更换了一台 26 年的隧道式洗衣机，翻新了 4 个房间并增加了 16 个通风房间老鼠繁殖屏障内 4 个房间中的 3 个都有老鼠架。这个新提议的项目将在小鼠饲养屏障（屏障支持 19 个 PI 实验室）的剩余空间中添加 5 个通风小鼠架，这些小鼠架将与大型笼子（180 英寸/笼 - 36 个笼子/架）一起购买，可用于通过与小笼子（75 英寸2/笼）互换（2 个小笼子可放入 1 个大笼子的插槽中），可以在繁殖屏障中的任何架子上进行操作。我们建议在繁殖屏障中使用大型笼子，以便我们能够支持三重繁殖，并根据第 8 版 NIH 指南建议为每个繁殖雌性提供足够的空间。其次，我们建议在无特定病原体（SPF）研究室的 4 个小鼠室中翻新并添加 20 个通风架（5 个架/室）。这些建议的通风机架是单面单元，每个单元可容纳 72 个笼子（75 英寸2/笼）。这种机架格式将使我们的房间笼子容量增加 25%（288 至 360 个笼子）。该 SPF 小鼠研究套件目前支持 41 个 PI 实验室。这些房间目前已接近满员，3 名从事小鼠研究项目的新教员计划在 2014 年 1 月之前将他们的小鼠转移到 ARF。这 3 名教员中的 2 人是癌症中心的成员，我们的目标是让他们与其他研究人员共处一地。我们的小鼠癌症研究用户。该项目将增加该套件的容量以支持这一目标。 SPF 小鼠研究室的两个手术室目前拥有中央氧气和吸入异氟烷麻醉装置，并通过我们建筑的排气装置清除废麻醉气体。其中一间房间设有 II 级 A2 生物安全柜，可保护小鼠免受潜在微生物污染并保证操作员安全（仅限颗粒）。其中一间房间的柜子是木制的，两个房间的柜子的数量和格式都不足以支持这间套房的用户。因此，我们建议升级两个手术室的柜子，以提高隔离安全设备存储的功能，在其中一个手术室中添加一个带有柜子的新水槽，并添加一个移动 HEPA 过滤器手术站。总的来说，这个项目是从静态微型隔离小鼠笼过渡到通风笼的延续。该项目的完成对于我们继续实现我们的战略和计划目标至关重要，这些目标是： 扩大 NIH 和 UNM HSC 之间富有成效的伙伴关系；加强对 HSC 特色项目（脑部和行为疾病、癌症、心血管和代谢疾病、儿童健康、环境健康以及传染病和免疫）的支持；扩大与 ARF 的新兴协同效应的发展，作为我们临床和转化科学中心奖 (CTSC) 的技术核心之一；提高动物护理依从性；并维持 HSC 自 1973 年以来一直持续的 AAALAC 认证。该项目下的新设备将通过笼子通风和建筑物排气来改善动物房和笼子的空气质量，从而改善动物护理，并通过节约能源和水（更少）提高新墨西哥大学的可持续发展目标经常更换笼子/卫生）。劳动力和笼具供应的成本也将降低，这将降低核心用户的成本上升。总之，我们不断寻求通过跨学科 CTSC 加快发现步伐的方法，其总体目标是促进更健康的公众和更实惠的患者护理。