Drugs of Abuse and Memory Span

滥用药物和记忆广度

• 批准号: 8626118
• 负责人: Joseph Mark Galizio
• 金额: $ 43.61万
• 依托单位: UNIVERSITY OF NORTH CAROLINA WILMINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8626118
• 关键词: Accounting; Address; Adverse effects; Animal Model; Animals; Anti-Cholinergics; Benzodiazepines; Biological Assay; Chlordiazepoxide; Cognitive; Cognitive deficits; Dose; Familiarity; Goals; Grant; Human; Impaired cognition; Impairment; Ketamine; Learning; Measures; Memory; Methods; Modeling; N-Methylaspartate; Neurosciences; Odors; Performance; Pharmaceutical Preparations; Principal Investigator; Procedures; Process; Psychopharmacology; Psychotropic Drugs; Public Health; Rattus; Relative (related person); Research; Research Personnel; Risk; Robin bird; Sampling; Scopolamine; Short-Term Memory; Stimulus; Students; Task Performances; Testing; Work; base; design; dizocilpine; drug of abuse; ecstasy; episodic like memory; improved; interest; memory process; memory recognition; programs; public health relevance; skills

Project Summary/Abstract: Drugs of abuse are associated with a variety of cognitive deficits including disruption of learning and memory. Animal models are needed to better assess the cognitive risks of use and abuse of psychoactive drugs and the studies completed during the current grant period developed promising procedures to assess drug effects on memory capacity in rats. The proposed work will focus on five key drugs (CDZ, scopolamine, MDMA, DZP and ketamine) of particular interest based on the effects observed in our preliminary work. These proposed studies will 1) use a more refined measure of memory load to test the hypothesis that drug effects in our recently completed studies might have been influenced by attentional factors due the use of multiple distractors. 2) Use a list memory procedure that permits the analysis of both the number of stimuli to remember and the retention interval to test the hypothesis that these drugs have different actions on recognition memory: i.e., NMDA antagonist effects depend on memory load, whereas MDMA, CDZ, and scopolamine effects are delay-dependent. 3) Use an odor list task that includes test trials separating responding based on relative familiarity versus recollection of specific episode sequences to test the hypothesis that NMDA antagonists impair both familiarity and episodic-like memory processes, whereas CDZ, and scopolamine spare familiarity, and MDMA spares both processes. Finally, the proposed research will provide an ideal opportunity for students to develop skills and background in psychopharmacology and neuroscience.

项目摘要/摘要：滥用药物与多种认知功能有关 缺陷，包括学习和记忆障碍。需要动物模型 更好地评估使用和滥用精神药物的认知风险以及 在当前资助期内完成的研究制定了有希望的程序 评估药物对大鼠记忆能力的影响。拟议的工作将重点关注五个方面 基于特别兴趣的关键药物（CDZ、东莨菪碱、MDMA、DZP 和氯胺酮） 关于我们在前期工作中观察到的影响。这些拟议的研究将 1）使用 更精确的记忆负荷测量来检验药物影响我们的假设 最近完成的研究可能受到注意力因素的影响 使用多个干扰物。 2) 使用允许分析的列表内存过程 需要记住的刺激数量和检验假设的保留间隔 这些药物对识别记忆有不同的作用：即 NMDA 拮抗剂 效果取决于记忆负荷，而 MDMA、CDZ 和东莨菪碱的效果则取决于记忆负荷。 延迟相关。 3) 使用气味列表任务，其中包括区分响应的测试试验 基于对特定情节序列的相对熟悉度与记忆来测试 NMDA 拮抗剂会损害熟悉度和情景记忆的假设 过程，而 CDZ 和东莨菪碱则不熟悉，而 MDMA 则两者都不熟悉 流程。最后，拟议的研究将为学生提供理想的机会 培养精神药理学和神经科学的技能和背景。