Drugs of Abuse and Memory Span

滥用药物和记忆广度

• 批准号: 8471411
• 负责人: Joseph Mark Galizio
• 金额: $ 1.62万
• 依托单位: UNIVERSITY OF NORTH CAROLINA WILMINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8471411
• 关键词: Acute; Address; Adverse effects; Animal Model; Animals; Anti-Cholinergics; Behavior; Benchmarking; Benzodiazepines; Biological Assay; Chlordiazepoxide; Cognitive; Cognitive deficits; Complex; Dose; Exposure to; Goals; Hallucinogens; Human; Impaired cognition; Ketamine; Learning; Memory; Methamphetamine; Methodology; Methods; Methylphenidate; Midazolam; Modeling; Morphine; N-Methylaspartate; Neurosciences; Odors; Opiates; Performance; Pharmaceutical Preparations; Procedures; Process; Psychopharmacology; Psychotropic Drugs; Radial; Rattus; Research; Research Personnel; Residual state; Risk; Rodent; Sampling; Scopolamine; Short-Term Memory; Sorting - Cell Movement; Stimulus; Students; Swimming; Techniques; Testing; Wood material; arm; behavioral pharmacology; dizocilpine; drug of abuse; forgetting; neurotoxic; novel; psychostimulant; public health relevance; research study; skills; tool

DESCRIPTION (provided by applicant): Drugs of abuse are associated with a variety of cognitive deficits including disruption of learning and memory. Animal models are needed to better assess the cognitive risks of use and abuse of psychoactive drugs. However, procedures available to study memory in rodents are generally limited to the study of retention of a single stimulus or place across a delay interval. The goal of the proposed research is to elaborate a recently developed test that assesses rodent's ability to remember an increasing number of odors within a single experimental session: the olfactory span task. This procedure offers the novel potential to analyze the effects of drugs as a function of memory load. Aim 1 experiments will determine the acute effects of drugs of abuse and other selected compounds that are thought to have amnestic effects on olfactory memory using the span procedure including benzodiazepines (chlordiazepoxide, midazolam), NMDA antagonists (dizocilpine, ketamine), opiates (morphine), psychostimulants (methylphenidate, methamphetamine, MDMA), and an anticholinergic hallucinogen (scopolamine). The Aim 2 experiments will examine residual effects on memory span after exposure to neurotoxic doses of MDMA and methamphetamine that have been associated with amnestic effects in humans and in some animal models. An overarching goal of the project is to develop and evaluate this new methodology as a tool in the assessment of the effects of drugs on memory. Finally, the proposed research will provide an ideal opportunity for students to develop skills and background in psychopharmacology and neuroscience. PUBLIC HEALTH RELEVANCE: Drugs of abuse may produce cognitive deficits and this project will develop a new animal model to identify and characterize acute and residual effects of abused drugs on memory capacity.

描述（由申请人提供）：滥用药物与多种认知缺陷有关，包括学习和记忆障碍。需要动物模型来更好地评估使用和滥用精神活性药物的认知风险。然而，可用于研究啮齿类动物记忆的程序通常仅限于研究单个刺激或在延迟间隔内的位置的保留。拟议研究的目标是详细阐述最近开发的一项测试，该测试可评估啮齿动物在单次实验中记住越来越多气味的能力：嗅觉跨度任务。该过程为分析药物对记忆负荷的影响提供了新的潜力。目标 1 实验将使用跨度程序确定滥用药物和其他被认为对嗅觉记忆有遗忘作用的选定化合物的急性影响，包括苯二氮卓类药物（利眠宁、咪达唑仑）、NMDA 拮抗剂（地佐西平、氯胺酮）、阿片类药物（吗啡） 、精神兴奋剂（哌醋甲酯、甲基苯丙胺、MDMA）和抗胆碱能致幻剂（东莨菪碱）。 Aim 2 实验将检查暴露于神经毒性剂量的 MDMA 和甲基苯丙胺后对记忆持续时间的残留影响，这些剂量与人类和某些动物模型的遗忘效应有关。该项目的首要目标是开发和评估这种新方法，作为评估药物对记忆影响的工具。最后，拟议的研究将为学生提供发展精神药理学和神经科学技能和背景的理想机会。 公共卫生相关性：滥用药物可能会产生认知缺陷，该项目将开发一种新的动物模型，以识别和表征滥用药物对记忆能力的急性和残留影响。