Genetic Analyses For Epidemiologic Studies Of Respiratory Disease

呼吸道疾病流行病学研究的基因分析

• 批准号: 8336533
• 负责人: Stephanie London
• 金额: $ 28.95万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336533
• 关键词: Adult; Asthma; Biology; Blood specimen; Child; Childhood Asthma; DNA; Environmental Exposure; Epidemiologic Studies; Epidemiology; Epigenetic Process; Genetic; Genetic Polymorphism; Genotype; Hypersensitivity; Laboratories; London; Lung diseases; Maternal Exposure; Methylation; Mothers; Role; Sampling; Umbilical Cord Blood; Work; airway obstruction; follow-up; gene environment interaction; genetic analysis; genome wide association study; genome-wide; pulmonary function; respiratory

This project describes the role of the lab of Stephanie London in the Laboratory of Respiratory Biology in support of her epidemiologic studies. The laboratory is engaged in genetic and epigenetic analyses to support Dr. Londons epidemiologic projects. In the past year, we have focused on genome wide approaches. The lab supports follow-up of findings from our genome wide association studies of childhood asthma as well as adult pulmonary function. It also supports our project to analyze genome-wide methylation platform (Illumina 450K) using cord blood samples from the Norwegian Mother and Child Study. We are examining associations with maternal exposures and childhood asthma. The lab has been doing genotyping of polymorphisms that may influence associations between exposures and epigenetic changes. We have also evaluate new commercial platforms for assessing global methylation. The lab has prepared samples for high throughput genetic and epigenetic platforms.

该项目描述了斯蒂芬妮·伦敦实验室在呼吸生物学实验室中在支持她的流行病学研究方面的作用。该实验室从事遗传和表观遗传分析，以支持伦敦博士的流行病学项目。在过去的一年里，我们专注于全基因组方法。该实验室支持对儿童哮喘和成人肺功能的全基因组关联研究的结果进行跟踪。它还支持我们使用挪威母婴研究的脐带血样本分析全基因组甲基化平台 (Illumina 450K) 的项目。我们正在研究与母亲接触和儿童哮喘之间的关联。该实验室一直在对可能影响暴露与表观遗传变化之间关联的多态性进行基因分型。我们还评估了用于评估全球甲基化的新商业平台。该实验室已为高通量遗传和表观遗传平台准备了样品。