The National Couples Health and Time Use Stress Biology Study (NCHAT-BIO): Biobehavioral Pathways to Population Health Disparities in Sexual Minorities

全国夫妻健康和时间使用压力生物学研究 (NCHAT-BIO)：性别少数人口健康差异的生物行为途径

• 批准号: 10742339
• 负责人: Lisa Michelle Christian
• 金额: $ 30.41万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10742339
• 关键词: 18 year old; Accounting; Acute; Address; Adult; Affect; Age; Age Years; Anxiety; Articulation; Asian population; Asthma; Behavioral; Biological; Biological Assay; Biological Markers; Biology; Black Populations; Blood; C-reactive protein; Cardiovascular Diseases; Cellular Immunity; Chronic; Chronic Disease; Chronic stress; Cohort Studies; Color; Complex; Couples; Data; Data Collection; Databases; Diabetes Mellitus; Diet; Discrimination; Dryness; EBV reactivation from latency; Ethnic Origin; Exercise; Exhibits; Funding; Future; Happiness; Health; Health behavior; Heterosexuals; Human Herpesvirus 4; Immune; Immune system; Immunologic Markers; Impairment; Individual; Inflammation; Interleukin-6; Intervention; Investigation; Knowledge; Latinx population; Lesbian Gay Bisexual; Link; Literature; Malignant Neoplasms; Measures; Mediating; Mental Depression; Methodology; National Institute of Child Health and Human Development; Not Hispanic or Latino; Obesity; Outcome; Participant; Pathway interactions; Pattern; Personal Satisfaction; Population; Psychological Factors; Public Health; Race; Recording of previous events; Reduce health disparities; Reporting; Research; Resources; Risk; Sample Size; Sampling; Sleep disturbances; Spottings; Stigmatization; Stress; Testing; Time Study; United States National Academy of Sciences; Victimization; Violence; Woman; access restrictions; biobehavior; cohort; experience; health disparity; health disparity populations; immune function; immunoregulation; inflammatory marker; internalized stigma; intersectionality; men; microaggression; minority stress; minority stressor; modifiable behavior; mortality; novel; obesity risk; optimism; pandemic disease; risk prediction; sexual identity; sexual minority; sexual minority stress; social stigma; stressor; substance use; time use; virtual

Project Summary Sexual minorities have significantly greater risk for obesity, asthma, diabetes, cardiovascular disease, and some cancers compared to heterosexuals. A key driver of these health disparities is chronic stress related to stigmatization. Compounding this, racial and ethnic sexual minorities have complex intersecting identities and experiences of stress that may exacerbate negative health outcomes relative to non-Hispanic White sexual minorities. Chronic stressors can affect the immune system by both increasing inflammation and impairing cellular immunity, a pattern causally predictive of risk for acute illness, chronic disease, and mortality. Funded by NICHD and fielded during the pandemic, the National Couples’ Health and Time Study (NCHAT) includes 5,157 US adults 18-60 years of age, with oversamples of Black, Latinx, and Asian individuals. With 2,230 (43.2%) identifying as gay, lesbian, bisexual, or other identifies, NCHAT is the only population-representative study with a fully-powered subsample of sexual minorities in the US. Capitalizing on the extraordinary opportunity to address the empirical gap in data on stress biology among sexual minorities, particularly those with intersecting identities, we added a pilot biological data collection (dried blood spots; DBS) to NCHAT to create the NCHAT Stress Biology Study (NCHAT-BIO). Biological data collection is complete, but samples are yet to be assayed. In this R21, we will assay these samples to measure inflammation (interleukin-6, C-reactive protein) and cellular immune function (Epstein-Barr virus reactivation). In a diverse cohort of 763 NCHAT participants, we will address these empirical aims: Aim 1: Delineate differences in immune regulation among sexual minorities versus heterosexuals. Hypothesis: Sexual minorities will exhibit greater inflammation and poorer cellular immune function with differential effects among lesbian, gay, and bisexual women and men. Aim 2: Examine effects of stigma, discrimination, and intersectionality on biomarkers of immune dysregulation within a minority stress framework. Hypotheses: Experiences of stigma and discrimination will predict greater inflammation and poorer cellular immune function with stronger effects among sexual minorities and, in particular, sexual minority participants of color. Aim 3: Identify modifiable behaviors and treatable psychological factors linking stress with immune dysregulation. Hypotheses: Modifiable health behaviors (substance use, exercise, diet) and treatable psychological factors (depression, anxiety, sleep disturbance) will mediate the link between sexual minority stress with immune dysregulation, presenting targets for intervention. NCHAT-BIO offers a uniquely comprehensive and methodologically rigorous investigation of stress biology among sexual minorities in the US, permitting novel tests of mechanisms linking stress and health within a minority stress framework. This R21 will support a future R01 addressing longitudinal changes in stress biology in the NCHAT cohort.

项目概要 性少数群体患肥胖、哮喘、糖尿病、心血管疾病、 与异性恋者相比，这些健康差异的一个关键驱动因素是与慢性压力有关。 种族和族裔性少数群体具有复杂的交叉身份，这使得污名化更加严重。 和压力经历可能会加剧非西班牙裔白人的负面健康相关结果 慢性压力源会通过增加炎症和影响免疫系统。 损害细胞免疫，这是急性疾病、慢性疾病和死亡风险的因果预测模式。 由 NICHD 资助并在大流行期间开展的全国夫妻健康和时间研究 (NCHAT) 包括 5,157 名 18-60 岁的美国成年人，其中对黑人、拉丁裔和亚洲人进行了过度采样 NCHAT 是唯一有 2,230 名（43.2%）个人被认定为男同性恋、女同性恋、双性恋或其他身份的人。 利用美国性少数群体的充分样本进行人口代表性研究。 这是解决性少数群体压力生物学数据经验差距的绝佳机会， 特别是那些具有交叉身份的人，我们添加了试点生物数据收集（干血点； DBS）与 NCHAT 合作创建 NCHAT 应激生物学研究 (NCHAT-BIO)。 完成，但样品尚未化验 在本 R21 中，我们将化验这些样品以进行测量。 炎症（白细胞介素 6、C 反应蛋白）和细胞免疫功能（Epstein-Barr 病毒再激活）。 在由 763 名 NCHAT 参与者组成的多元化队列中，我们将实现以下实证目标： 目标 1：描绘性少数群体与性少数群体在免疫调节方面的差异 假设：性少数群体会表现出更严重的炎症和更差的细胞免疫系统。 目标 2：检查影响。 免疫失调生物标志物的耻辱、歧视和交叉性 假设：耻辱和歧视的经历将预示更大的压力。 炎症和较差的细胞免疫功能对性少数群体的影响更大， 特别是有色人种的性少数参与者。目标 3：确定可改变的行为和可治疗的行为。 将压力与免疫失调联系起来的心理因素：假设：可改变的健康行为。 （物质使用、运动、饮食）和可治疗的心理因素（抑郁、焦虑、睡眠障碍）将 调解性少数压力与免疫失调之间的联系，提出干预目标。 NCHAT-BIO 提供独特、全面且方法严谨的压力调查 美国性少数群体的生物学，允许对压力和健康之间的机制进行新的测试 该 R21 将支持未来的 R01，解决少数群体压力框架内的纵向变化。 NCHAT 队列中的应激生物学。