PILOT/EXPLORATORY CORE

试点/探索性核心

• 批准号: 7878554
• 负责人: JAY MAGAZINER
• 金额: $ 16.77万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7878554
• 关键词: Advisory Committees; Aging; American; Animal Model; Animals; Applications Grants; Area; Award; Basic Science; Chronic; Clinical; Communities; Complement; Data; Data Analyses; Development; Disability phenotype; Disabled Persons; Discipline; Elderly; Enrollment; Ensure; Exercise; Faculty; Fostering; Funding; Future; Geriatrics; Goals; Grant; Guidelines; Health; Hip Fractures; Human; Individual; Inflammation; Insulin Resistance; Intervention; Laboratories; Leadership; Measures; Medical; Mentorship; Monitor; Neuronal Plasticity; Physical Function; Physical activity; Pilot Projects; Prevention; Recovery; Recovery of Function; Rehabilitation Research; Rehabilitation therapy; Research; Research Design; Research Personnel; Research Proposals; Resources; Robotics; Safety; Science; Scientific Evaluation; Skeletal Muscle; Stroke; Testing; Time; Training; Translational Research; Work; base; career development; chronic stroke; design; disability; dosage; human subject protection; innovation; insight; interdisciplinary collaboration; member; programs; research and development; research study; response; symposium; therapy design

The goal of the Pilot and Exploratory Studies Core (P/EC) is to provide start-up support for high quality research proposals of high relevance to the Center's overall theme, exploring mechanisms underlying the disability phenotype in older persons and the functional and clinical responses to exercise rehabilitation interventions designed to slow the progression of disability and promote recovery. To accomplish this goal, the P/EC will select and fund the highest quality pilot and exploratory research studies to acquire information needed to select or design future projects that will optimize the recovery of individuals who are older and disabled following stroke or hip fracture. Each submitted proposal will first receive an evaluation for scientific merit by at least two external reviewers, and then be further evaluated by the Core Leadership Executive Committee (CLEC) and the Program Advisory Committee (PAC) for its relevance to Center objectives. The P/EC will assist P/EC investigators in accessing resources from other cores and institutional research programs and centers, monitor and evaluate the progress of PE/C studies, and ensure the safety and protection of human subjects enrolled in all P/EC studies. The UM-OAIC's former Research Development Core (RDC) has made 43 pilot grant awards since its inception in 1994. Many of these awards were to junior faculty members who have now established themselves as productive independent researchers in geriatric medicine and cognate disciplines. Five innovative and methodologically rigorous proposals have been selected for the current competitive renewal, including studies of (a) the mechanisms by which inflammation increases insulin resistance in stroke; (b) the functional recovery of older vs younger skeletal muscles after eccentric exercise in an animal model; (c) the effects of adaptive physical activity on functional measures in a non-medical community; (d) the effects of post hip fracture rehabilitation exercise on elders and (e) comparison of robotic and passive training approaches in individuals with chronic stroke. The P/EC will be directed by Dr. Mary Rodgers, who has served as director of the OAlC's Functional and Neuroplasticity Core, and will be co-directed by Dr. Jay Magaziner, who has served as co-Pi of the Pepper Center. Drs. Rodgers and Magaziner will work closely with the Directors of the RCDC to assist RCDC junior faculty as they develop plans for competitive Pilot Grant applications for P/EC consideration.

试点和探索性研究核心（P/EC）的目标是为高 高质量的研究建议与该中心的整体主题高度相关，探索机制 老年人的残疾表型以及对 旨在减缓残疾进展并促进的锻炼康复干预措施 恢复。为了实现这一目标，P/EC将选择并资助最高质量的飞行员， 探索性研究，以获取选择或设计未来项目所需的信息 将优化中风或髋部骨折后年长和残疾的人的恢复。 每个提交的提案将首先获得至少两个外部的科学价值评估 审阅者，然后由核心领导力执行委员会（CLEC）和 计划咨询委员会（PAC）与中心目标有关。 P/EC将有助于 P/EC调查人员从其他核心和机构研究计划访问资源 和中心，监视和评估PE/C研究的进度，并确保安全和 对所有P/EC研究的人类受试者的保护。 自从UM-OAIC的前研究开发核心（RDC）以来已获得43个试点赠款奖 它于1994年成立。其中许多奖项都是为现在拥有的初级教师 将自己确立为老年医学的生产性独立研究人员 学科。为该公司选择了五项创新和方法严格的建议 当前的竞争性更新，包括对（a）炎症的机制的研究 增加中风的胰岛素抵抗； （b）年龄较大的骨骼的功能恢复 动物模型中偏心运动后的肌肉； （c）自适应体育锻炼对 非医疗社区的功能措施； （d）髋部骨折康复的影响 对长者进行运动以及（e）个人的机器人和被动训练方法的比较 慢性中风。 P/EC将由玛丽·罗杰斯（Mary Rodgers）博士执导，他曾担任OALC职能的主任 神经可塑性核心，并将由Jay Magaziner博士共同执导，他曾担任The Co-Pi 胡椒中心。博士。 Rodgers和Magaziner将与RCDC的董事紧密合作以协助 RCDC初级教师为P/EC制定了竞争性试点赠款申请的计划 考虑。