Novel Intervention to Influence Muscle Plasticity in Veterans with SCI

影响 SCI 退伍军人肌肉可塑性的新型干预措施

基本信息

  • 批准号:
    8898720
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-01-01 至 2013-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Novel Intervention to Influence Muscle Plasticity in Veterans with SCI The long-term goal is to develop a rehabilitation strategy to prevent the deleterious muscular and metabolic complications (diabetes) that follow individuals with complete spinal cord injury (SCI). Up to 300, 000 persons are living with SCI, and more than 10% receive their care within the VA health system. Secondary complications (muscle atrophy, and diabetes) in the decades after SCI cost society between 4 and 7 billion dollars annually. A method to prevent these complications would not only provide substantial savings, but also could profoundly improve the quality of life of veterans with SCI. Recently, we verified that a certain dose of muscle force maintained the calf muscle of the lower leg for over 2 years following SCI. We now aspire to determine if various doses of muscle force preferentially up regulate protein synthesis pathways, down regulate protein degradation pathways, and improve blood metabolic markers during a novel functional exercise. Three specific aims will address these hypotheses by inducing various doses of stress to the lower extremities during stance and neuromuscular electrical stimulation. Aim 1 will compare 3 tiers of muscle force training induced via (0, 10, and 20 Hz stimulation) on muscle physiological properties (fatigue, force, potentiation) over a 12 week training and detraining period. Aim 2 will compare the effects of 3 muscle forces (0, 10 Hz, 20 Hz) on molecular markers of muscle atrophy. Aim 3 will compare the effects of three muscle forces (0,. 10 Hz, and 20 Hz) on insulin sensitivity and inflammatory markers. The combined effect of cardiovascular stress through stance and muscle activation offers a unique strategy to affect metabolic changes. This study is novel because it uses an intervention that is feasible, quantifiable, portable, and dose of muscle force specific. This research is grounded by sound scientific principles, but also has the potential to rapidly translate to the VA health system to influence health quality. In the next several decades, a cure for spinal cord injury is a realistic possibility. Without a method to preserve the integrity of paralyzed lower limbs, the veterans with SCI injured today will be unable to participate in those trials because of a deteriorated musculoskeletal system. Moreover, preservation of muscular systems may increase insulin sensitivity and improve the veterans overall health today. We believe that future clinical trials will need the dose information from this trial to establish efficacy. This intervention has excellent potential for efficacy, but also is likely to be economical and easily integrated into the daily lives of veterans with SCI.
描述(由申请人提供): 在具有SCI的退伍军人中影响肌肉可塑性的新型干预措施长期目标是制定一种康复策略,以防止有害的肌肉和代谢并发症(糖尿病),跟随患有完全脊髓损伤的人(SCI)。多达300,000人居住在SCI中,超过10%的人在VA卫生系统中获得护理。在SCI社会的几十年中,次要并发症(肌肉萎缩和糖尿病)每年损失4至70亿美元。一种预防这些并发症的方法不仅可以节省大量节省,而且可以深刻地改善SCI退伍军人的生活质量。最近,我们验证了SCI后2年以上,一定剂量的肌肉力保持下腿的小腿肌肉。现在,我们渴望确定各种剂量的肌肉力是否优先提高蛋白质合成途径,下调蛋白质降解途径,并在新的功能运动中改善血液代谢标记。三个特定的目标将通过在姿势和神经肌肉电刺激期间引起下肢的各种应力来解决这些假设。 AIM 1将比较在12周的训练和下降期间,在肌肉生理特性(疲劳,力,力,增强)上通过(0、10和20 Hz刺激)引起的肌肉力量训练的3层。 AIM 2将比较3个肌肉力(0,10 Hz,20 Hz)对肌肉萎缩分子标记的影响。 AIM 3将比较三种肌肉力(0,10 Hz和20 Hz)对胰岛素敏感性和炎症标记的影响。通过姿势和肌肉激活的心血管应激的综合作用为影响代谢变化提供了独特的策略。这项研究之所以新颖,是因为它使用了可行,可量化,便携性和特定肌肉力量的干预措施。这项研究是基于合理的科学原理,但也有可能快速转化为VA卫生系统以影响健康质量。在接下来的几十年中,治愈脊髓损伤是现实的可能性。没有一种方法来保留瘫痪的下肢完整性,今天有SCI受伤的退伍军人将由于肌肉骨骼系统恶化而无法参加这些试验。此外,肌肉系统的保存可能会提高胰岛素的敏感性,并改善当今退伍军人的整体健康。我们认为,未来的临床试验将需要该试验中的剂量信息以确立功效。这种干预具有巨大的功效潜力,但也很可能是经济的,并且很容易融入具有SCI的退伍军人的日常生活中。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Dynamic-position-sense impairment's independence of perceived knee function in women with ACL reconstruction.
  • DOI:
    10.1123/jsr.21.1.44
  • 发表时间:
    2012-02
  • 期刊:
  • 影响因子:
    1.7
  • 作者:
    A. Littmann;Masaki Iguchi;S. Madhavan;Jamie L Kolarik;R. Shields
  • 通讯作者:
    A. Littmann;Masaki Iguchi;S. Madhavan;Jamie L Kolarik;R. Shields
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RICHARD K. SHIELDS其他文献

RICHARD K. SHIELDS的其他文献

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{{ truncateString('RICHARD K. SHIELDS', 18)}}的其他基金

Long Duration Activity and Metabolic Control after Spinal Cord Injury
脊髓损伤后的长期活动和代谢控制
  • 批准号:
    8960498
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Long Duration Activity and Metabolic Control after Spinal Cord Injury
脊髓损伤后的长期活动和代谢控制
  • 批准号:
    9478256
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Novel Intervention to Influence Muscle Plasticity in Veterans with SCI
影响 SCI 退伍军人肌肉可塑性的新型干预措施
  • 批准号:
    8894382
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
Novel Intervention to Influence Muscle Plasticity in Veterans with SCI
影响 SCI 退伍军人肌肉可塑性的新型干预措施
  • 批准号:
    7863128
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
Mechanical stress and skeletal plasticity after spinal cord injury in humans
人类脊髓损伤后的机械应力和骨骼可塑性
  • 批准号:
    7983447
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Mechanical stress and skeletal plasticity after spinal cord injury in humans
人类脊髓损伤后的机械应力和骨骼可塑性
  • 批准号:
    8117001
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Mechanical stress and skeletal plasticity after spinal cord injury in humans
人类脊髓损伤后的机械应力和骨骼可塑性
  • 批准号:
    8302328
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Mechanical stress and skeletal plasticity after spinal cord injury in humans
人类脊髓损伤后的机械应力和骨骼可塑性
  • 批准号:
    8476243
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Mechanical stress and skeletal plasticity after spinal cord injury in humans
人类脊髓损伤后的机械应力和骨骼可塑性
  • 批准号:
    8675883
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Neuro-Musculoskeletal Plasticity after SCI
SCI 后的神经肌肉骨骼可塑性
  • 批准号:
    7884534
  • 财政年份:
    2000
  • 资助金额:
    --
  • 项目类别:

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