The Mount Sinai Transdisciplinary Center on Early Environmental Exposures

西奈山早期环境暴露跨学科中心

• 批准号: 8619147
• 负责人: Robert O Wright
• 金额: $ 90.22万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-18 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8619147
• 关键词: Address; Adolescence; Antioxidants; Area; Bioinformatics; Biological Markers; Birth; Child; Childhood; Clinical; Collaborations; Commit; Communication; Communities; Community Outreach; Core Facility; Development; Disadvantaged; Discipline; Disease; Endocrine; Environmental Epidemiology; Environmental Exposure; Environmental Health; Epigenetic Process; Faculty; Fellowship; Fostering; Functional disorder; Funding; Future; Genetic; Grant; Growth; Health; Health Sciences; Hospitals; Informatics; Institutes; Laboratories; Life; Longevity; Medicine; Metabolic; Mission; Molecular; National Institute of Environmental Health Sciences; Nutritional; Oxidants; Phenotype; Physicians; Pilot Projects; Placenta; Population; Public Health; Research; Research Personnel; Research Training; Schools; Scientist; Seeds; Stress; Translating; Translational Research; United States; Work; base; biobank; biological research; career; career development; chemical genetics; cohort; community organizations; design; disability; disorder prevention; disorder risk; evidence base; health science research; immunoregulation; infancy; innovation; interest; medical schools; medical specialties; novel strategies; population based; programs; prospective; public health relevance; social; statistics

DESCRIPTION (provided by applicant) The Icahn School of Medicine at Mount Sinai seeks to form a new Environmental Health Sciences Core Center, the Mount Sinai Transdisciplinary Center on Health Effects of Early Environmental Exposures. The Center will leverage Mount Sinai's remarkable recent growth and build on their nationally and internationally recognized programs in children's environmental health. The Center's mission is to understand how environmental exposures in early life influence health, development, and risk of disease and dysfunction across the life span, in infancy, childhood, adolescence and beyond. The investigators will study the health impacts of chemical, genetic, nutritional, and social exposures and the interactions among them. Their approach will be transdisciplinary and highly translational. The investigators will combine clinical, population-based and biological research with leading-edge genetics, epigenetics, and bioinformatics in the setting of a hospital-based, urban School Of Medicine. Through their clinical and community partnerships, they will translate their research findings into evidence-based approaches for disease prevention and treatment. To focus their research, the Center will establish three Research Groups: Endocrine and Metabolic Disruption, Neuro-Immunomodulation, and Oxidant-Antioxidant Imbalance. These Research Groups will bring together basic scientists, clinicians and population scientists committed to developing new, transdisciplinary research in environmental health. The Research Groups will be supported by three Facility Cores: an Integrated Health Sciences Facility Core with sub-Cores in Exposure Biomarkers, Molecular Biomarkers, Clinical Population Access, and a Placenta Biobank; an Environmental Epidemiology, Statistics and Informatics Facility Core; and a clinically-oriented Phenotyping and Stress Assessment Facility Core. The Center supports a Pilot Project Program, a Career Development Program, and a Community Outreach and Engagement Core, committed to bidirectional communication and partnership with the diverse and disadvantaged communities that Mount Sinai serves. Mount Sinai has attracted well-funded senior faculty who will be leaders in the Center, built a strong base of NIEHS funding, constructed new laboratories, assembled multiple prospective birth cohorts, developed a successful research training fellowship in pediatric environmental health, developed a robust Pilot Project Program, gained designation as a WHO Collaborating Centre, and made significant scientific discoveries. The formation of an NIEHS Core Center will strengthen the program's identity, sustain the scientific capacity, and help build the careers of the young scientists who are our future leaders.

描述（由申请人提供） 西奈山伊坎医学院寻求建立一个新的环境健康科学核心中心，即早期环境暴露对健康影响的西奈山跨学科中心。 该中心将利用西奈山最近的显着增长，并以其国内和国际认可的儿童环境健康项目为基础。 该中心的使命是了解生命早期的环境暴露如何影响婴儿期、儿童期、青春期及以后的健康、发育以及疾病和功能障碍的风险。 研究人员将研究化学、遗传、营养和社会暴露对健康的影响以及它们之间的相互作用。 他们的方法将是跨学科的和高度转化的。研究人员将在以医院为基础的城市医学院的背景下，将临床、基于人群的生物学研究与前沿的遗传学、表观遗传学和生物信息学结合起来。通过他们的临床和社区合作伙伴关系，他们将把他们的研究成果转化为基于证据的疾病预防和治疗方法。 为了集中研究，该中心将设立三个研究组：内分泌和代谢紊乱、神经免疫调节和氧化剂-抗氧化剂失衡。这些研究小组将汇集基础科学家、临床医生和人口科学家，致力于在环境健康领域开展新的跨学科研究。研究小组将得到三个设施核心的支持：一个综合健康科学设施核心，其子核心包括暴露生物标志物、分子生物标志物、临床人群访问和胎盘生物库；环境流行病学、统计和信息学设施核心；以及面向临床的表型分析和压力评估设施核心。该中心支持试点项目计划、职业发展计划以及社区外展和参与核心，致力于与西奈山所服务的多元化和弱势社区进行双向沟通和合作。 西奈山吸引了资金雄厚的高级教职人员，他们将成为该中心的领导者，建立了强大的 NIEHS 资助基础，建造了新的实验室，组建了多个预期出生队列，在儿科环境健康方面成功建立了研究培训奖学金，开发了强大的试点项目项目计划被指定为世界卫生组织合作中心，并取得了重大科学发现。 NIEHS 核心中心的成立将增强该项目的特色，维持科学能力，并帮助建立未来领导者年轻科学家的职业生涯。