Developmental Changes in Neural Processes Underlying Impulsivity and ADHD

冲动和多动症背后的神经过程的发育变化

基本信息

批准号：
8661288
负责人：
JULIE B. SCHWEITZER
金额：
$ 73.24万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8661288
关键词：
Academic achievement Adolescence Adolescent and Young Adult Age Area Attention deficit hyperactivity disorder Behavior Behavioral Biological Markers Biological Models Brain Brain region California Clinical Cognitive Collaborations Collection Corpus striatum structure Decision Making Development Diagnostic Disease Drug usage Economics Emotional Equilibrium Functional Imaging Gambling Goals Impairment Impulsivity Individual Institutes Intervention Lead Life Measurement Measures Medial Mental Health Mental disorders Methods Modeling National Institute of Drug Abuse National Institute of Mental Health Neurophysiology - biologic function Outcome Outcomes Research Parietal Participant Pathway interactions Performance Population Prefrontal Cortex Prevention Process Public Health Recommendation Research Methodology Research Personnel Rewards Self-control as a personality trait Short-Term Memory Social Development Societies Strategic Planning Substance abuse problem System Testing Time United States National Institutes of Health Universities Ventral Striatum Visceral Vulnerable Populations Work Youth addiction age related base cognitive control cognitive neuroscience design discounting emerging adult experience high risk high school improved indexing innovation intervention program neurodevelopment neuroimaging physical conditioning prevent public health relevance relating to nervous system response reward processing success successful intervention translational approach translational medicine trend young adult

项目摘要

DESCRIPTION (provided by applicant): Problems with self-control are of major public health relevance as they are associated with physical and mental health, substance abuse and academic success impacting both individuals and society. The development of self-control is a critical step toward successful independence in young adulthood. Attention- deficit/hyperactivity disorder (ADHD) is a highly prevalent disorder associated with elevated problems with self- control. We hypothesize that poor self-control in ADHD leads to their impaired academic achievement and poor high school graduation rates. An improved understanding of the developmental trajectory of self-control will lead to more focused and successful intervention programs. Despite the public health importance of self-control, no studies have directly tested how the underlying mechanisms that determine self-control develop. It is hypothesized that a balance between cognitive control and reward response processes determine degree of self-control functioning. This project will characterize for the first time how cognitive control and reward-related neural functioning during adolescence and early adulthood independently contribute to self-control in both healthy development and ADHD. We will assess how changes in brain development occur in a two system model of self-control, which includes cognitive control (dorsolateral prefrontal cortex) and reward processing (ventral striatum) systems, and how the systems relate to broader impairments associated with ADHD. An additional goal is to assess if brain activity associated with self-control can serve as a biomarker for predicting academic performance. At the conclusion of these studies we will be able to identify age-related specific targets and recommendations for improving self-control. This work is a team effort by ADHD and functional imaging cognitive control researchers Julie Schweitzer and Catherine Fassbender at the UC Davis MIND Institute; Amanda Guyer at UC Davis with expertise in reward and emotional systems in neurodevelopment; Jamal Abedi at UC Davis with proficiency in measuring academic outcomes; and from Stanford University Samuel McClure, developer of the two-system model of self- control in neuro-economics, and Wouter van den Bos with experience in the development of social and reward based decision-making. Stephen Hinshaw at UC Berkeley brings to the contribution experience in ADHD, diagnostic issues, longitudinal research methods, measurement of academic issues in ADHD and general outcome research methods associated with the disorder. The geographic proximity of these collaborators from northern California will help to facilitate this collaboration. This project is consistent with th aims of the NIMH Strategic Plan Objective 2: "Charting Mental Illness Trajectories to Determine When, Where and How to Intervene." The project also overlaps with NIDA Strategic Plan Goal 1: "To prevent the initiation of drug use and the escalation to addiction" considering ADHD and problems with self-control are related to higher rates of substance abuse.

描述（由申请人提供）：自我控制的问题与公共卫生的主要意义相关，因为它们与身心健康，滥用药物以及影响个人和社会的学术成功有关。自我控制的发展是迈向成年后成功独立的关键一步。注意力缺陷/多动症（ADHD）是一种高度普遍的疾病，与自我控制的问题升高有关。我们假设多动症的自我控制差会导致他们的学术成就受损和高中毕业率不佳。对自我控制的发展轨迹的改进理解将导致更加集中和成功的干预计划。尽管自我控制的公共健康重要性，但尚未直接测试决定自我控制的基本机制如何发展。假设认知控制和奖励响应过程之间的平衡决定了自我控制功能的程度。该项目将首次表征青春期和成年早期在健康发展和ADHD中独立有助于自我控制的认知控制和与奖励相关的神经功能。我们将评估在两个自我控制系统模型中如何发生大脑发育的变化，其中包括认知控制（背外侧前额叶皮层）和奖励处理（腹侧纹状体）系统，以及该系统与与ADHD相关的更广泛障碍的关系。另一个目标是评估与自我控制相关的大脑活动是否可以作为预测学习成绩的生物标志物。在这些研究的结论中，我们将能够确定与年龄相关的特定目标和改善自我控制的建议。这项工作是ADHD和功能成像的团队努力，并在加州大学戴维斯分校Mind Institute的认知控制研究人员Julie Schweitzer和Catherine Fassbender努力。加州大学戴维斯分校的阿曼达·盖尔（Amanda Guyer）在神经发育方面具有奖励和情感系统方面的专业知识；加州大学戴维斯分校的贾马尔·阿贝迪（Jamal Abedi）熟练衡量学术成果；以及斯坦福大学塞缪尔·麦克卢尔（Samuel McClure），《神经经济学自我控制模型》的开发商，以及具有基于社会和奖励决策的发展经验的Wouter Van den Bos。加州大学伯克利分校的Stephen Hinshaw带来了多动症，诊断问题，纵向研究方法，多动症中的学术问题的测量以及与该疾病相关的一般结果研究方法的贡献经验。来自北加州的这些合作者的地理距离将有助于促进这一合作。该项目与NIMH战略计划目标2的目标一致：“绘制精神疾病轨迹以确定何时，何地和如何进行干预”。该项目还与NIDA战略计划目标1重叠：“考虑到多动症和自我控制问题的问题与较高的药物滥用率有关。