Nano-Crystalline Ceramic Coatings for the Reduction of Sliding Resistance of Orth

降低滑动阻力的纳米晶陶瓷涂层

• 批准号: 8729439
• 负责人: JASON E BURNS
• 金额: $ 64.74万
• 依托单位: N2 BIOMEDICAL, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8729439
• 关键词: Address; Adhesions; Aluminum Oxide; Appearance; Automobile Driving; Behavior; Benchmarking; Binding; Biocompatible Coated Materials; Businesses; Catheters; Ceramics; Child; Clinic; Clinical; Clinical Research; Clinical Trials; Control Groups; Data; Deposition; Development; Distal; Enrollment; Environment; Evaluation; Friction; Hardness; In Vitro; Ions; Laboratories; Lateral; Manufacturer Name; Measurement; Measures; Mechanics; Medical Device; Modification; Motion; Movement; North Carolina; Oral; Orthodontic; Orthodontic Appliances; Orthodontic Space Closure; Orthopedics; Outcome; Outcome Measure; Patients; Phase; Positioning Attribute; Procedures; Process; Production; Property; Prosthesis; Research; Research Project Grants; Resistance; Rotation; Safety; Selection Criteria; Series; Simulate; Slide; Small Business Innovation Research Grant; Staging; Surface; System; Technology; Testing; Thick; Time; TimeLine; Titania; Titanium; Tooth Movement; Tooth structure; Twin Multiple Birth; Universities; Work; Zirconium; active method; base; biomaterial compatibility; clinical efficacy; clinically significant; commercialization; cost; design and construction; expectation; improved; in vitro testing; indexing; innovation; nano; notch protein; programs; public health relevance; safety testing; success; surface coating; zirconium oxide

DESCRIPTION (provided by applicant): This Small Business Innovation Research project aims to develop hard ceramic coatings that will reduce the sliding resistance of archwires in their brackets during orthodontic treatment procedures. Excessive sliding resistance, which is a combination of friction and notching/binding behavior, works against tooth motion as the bracket slides along the wire into a new position, resulting in less predictable outcomes, and requiring increased force, treatment time, "chair time," and patient costs. If successful, the hard coatings will decouple sliding resistance from other properties of the arch-wire material, such as stiffness and provide the practitioner with new material systems for solving specific patient problems. Phase II will continue and expand highly promising Phase I results, in which thin coatings of alumina, zirconia, and titania were applied by ion beam assisted deposition (IBAD). The coatings decisively reduced sliding resistance of archwires in tests conducted by a major manufacturer of orthodontic appliances. The testing showed major reductions of both sliding friction and notching/binding behavior; and two of the coating materials demonstrated high resistance to scratching and delamination. The Phase II program will improve on coating properties through optimization of IBAD parameters, evaluate the coated archwires by in vitro testing in a more realistic configuration, and make a final selection of coating material and deposition parameters for a clinical study. Coated archwires will be evaluated in a limited clinica study at a major research university to test their efficacy in early and intermediate stages of tooth straightening in children. The commercialization potential of ceramic-coated orthodontic archwires is very high, as already demonstrated by the Phase I involvement by our industrial collaborators in laboratory testing. Phase III commercialization would be a straightforward expansion of Spire Biomedical's coating and surface- modification business, which specializes in surface treatments for orthopedic prostheses, catheters, and other medical devices.

描述（由申请人提供）：这个小型企业创新研究项目旨在开发硬陶瓷涂料，以在正畸治疗程序期间降低其支架中的ArchWires的滑动阻力。过度的滑动阻力是摩擦和切口/结合行为的结合，随着支架沿线滑动到新位置，导致牙齿运动可抵制牙齿运动，从而导致较低的预测结果，需要增加的力，治疗时间，“椅子时间”和患者成本。如果成功的话，硬涂层将与拱线材料的其他特性（例如刚度，并为从业者提供解决特定患者问题的新材料系统）的抗性。第二阶段将继续并扩大高度有希望的I期结果，其中氧化铝，氧化锆和二氧化钛的薄涂层通过离子束辅助沉积（IBAD）应用。这些涂层在主要的牙齿矫正器具制造商进行的测试中果断地降低了Arch因子的滑动阻力。测试显示滑动摩擦和切口/结合行为的主要减少。两种涂料表现出对刮擦和分层的高度耐药性。 II期计划将通过优化IBAD参数来改善涂料性能，在更现实的配置中通过体外测试来评估涂层拱门，并为临床研究做出最终选择涂层材料和沉积参数。将在一所主要的研究大学的一项有限的临床研究中评估涂层拱门，以测试其在儿童牙齿伸直的早期和中间阶段的功效。陶瓷涂层的正畸拱门的商业化潜力很高，正如我们工业合作者参与实验室测试的第一阶段参与所证明的那样。第三阶段的商业化将是Spire Biomedical涂层和表面修饰业务的直接扩展，该业务专门研究骨科假体，导管和其他医疗设备的表面处理。