Development of BioMEMS Pulsatile Hormone Delivery System

BioMEMS 脉冲激素输送系统的开发

• 批准号: 7213245
• 负责人: ERIC E NUXOLL
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7213245
• 关键词: Address; Adhesions; Adsorption; Aluminum Oxide; Awareness; Biocompatible; Bovine Serum Albumin; Carrier Proteins; Chemicals; Clinical Trials; Complement; Coupled; Development; Device or Instrument Development; Devices; Diagnostic; Drug Delivery Systems; Encapsulated; Environment; Ethylene Glycols; Failure; Fellowship; Fluorescence; Glucose; Goals; Hormones; Hydrogels; Individual; Industry; Investigation; Longevity; Measures; Mechanics; Membrane; Miniaturization; Names; Pharmaceutical Preparations; Physiological; Plasma; Proteins; Purpose; Reaction; Research; Research Activity; Rest; Semiconductors; Signal Transduction; Silicon; Solutions; Surface; System; Techniques; Technology; Testing; Therapeutic; Time; Training; base; biomaterial compatibility; concept; copolymer; design; ethylene glycol; implantable device; implantation; in vivo; miniaturize; monolayer; novel; protein transport; response; size; small molecule

DESCRIPTION (provided by applicant): This project adapts an existing bench-scale system for pulsatile drug delivery to make it suitable for subsequent in vivo studies. The system being adapted uses an environmentally-sensitive hydrogel membrane coupled with an enzymatic reservoir to convert a time-invariant glucose signal into oscillatory drug release from the reservoir. The major issues addressed for the adaption are miniaturization and biocompatibilization of the device. To miniaturize the device, it will be redesigned and fabricated using microelectromechanical systems (MEMS) fabrication techniques, including a novel membrane mounting strategy. Biocompatibilization of the device will involve PEGylation of its hard surfaces and the investigation of several nanoporous membranes for blocking protein transport to the hydrogel while small molecules freely pass. A novel membrane strategy based on self-assembled block copolymers will be compared against existing anodized alumina and micromachined polysilicon designs. The components will be tested for mass- transport and protein adhesion and the final device will be operated in blood plasma to demonstrate functionality in a more physiological environment.

描述（由申请人提供）：该项目适应了现有的台式系统，用于脉冲药物输送，以使其适合随后的体内研究。适应该系统使用对环境敏感的水凝胶膜，并加上酶促储层，将时间不变的葡萄糖信号转换为从储层中释放的振荡药物释放。适应性的主要问题是该设备的小型化和生物相容性。为了使设备进行微型化，将使用微机械系统（MEMS）制造技术对其进行重新设计和制造，包括新型的膜安装策略。该设备的生物兼容化将涉及其硬表面的质量化，并研究几种纳米孔膜，以阻止蛋白质转运到水凝胶，而小分子自由地通过。将比较一种基于自组装块共聚物的新型膜策略与现有的阳极氧化铝和微机械多硅硅的设计进行比较。该组件将测试用于质量运输和蛋白质粘附，最终设备将在血浆中进行操作，以在更生理的环境中证明功能。