Robust Self-Assembled Monolayers for Improved Hemocompatibility

坚固的自组装单层膜可改善血液相容性

基本信息

批准号：
7271061
负责人：
Dave Paden
金额：
$ 23.21万
依托单位：
LAUNCHPOINT TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2009-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7271061
关键词：
Acids Address Adhesions Adsorption Adult Alloys Aluminum Oxide Animals Apical Area Atomic Force Microscopy Biocompatible Coated Materials Biocompatible Materials Biological Assay Biomedical Engineering Blood Blood Cells Blood Tests Blood Volume Cannulations Carbon Carbon Dioxide Cardiac Cardiovascular system Cell Adhesion Cell Communication Cells Ceramics Chemicals Chemistry Childhood Class Clinical Coagulation Process Collaborations Complex Condition Custom Defect Dental Deposition Development Devices Effectiveness Electron Microscopy Ensure Environment Ethylene Glycols Evaluation Event Exhibits Eye Facility Construction Funding Category Feedback Fiber Funding Future Glass Goals Government Hydrocarbons Hydrogen Peroxide Hydrolysis Implant In Vitro Industry Investigation Left Left ventricular structure Legal patent Licensing Life Ligands Link Liquid substance Magnetism Measurement Mechanics Medical Device Methods Modeling Modification Molecular Conformation Molecular Weight Motor Nanostructures Natural graphite Numbers Object Attachment Orthopedics Oxides Oxygen Patients Performance Perfusion Persons Phase Phase II Clinical Trials Plague Plasma Plasma Proteins Platelet Activation Powder dose form Preparation Principal Investigator Process Property Proteins Protocols documentation Pump Purpose Range Rate Reaction Relative (related person)Research Resistance Risk Roentgen Rays S-1 Antimetabolite agent Sampling Scanning Shapes Silanes Silicon Site Solutions Solvents Spectrum Analysis Speed Standards of Weights and Measures Structure Sulfuric Acids Surface System Techniques Technology Testing Therapeutic Embolization Thromboembolism Thrombosis Thrombus Titanium Touchdown Ultrasonics Universities Water Whole Blood Work X ray spectroscopy abstracting base biomaterial compatibility blood pump chemical bond concept covalent bond crosslink density design ethylene glycol experience fiberglass functional group implantable device improved in vivo male member miniaturize monolayer nanoparticle novel pressure professor programs prototype relating to nervous system silane surface coating titanium dioxide ventricular assist device

项目摘要

DESCRIPTION (provided by applicant): Robust Self-Assembled Monolayers for Improved Hemocompatibility Principal Investigator: Brink, Damon Project Summary / Abstract Implantable blood-contacting medical devices such as left ventricular assist devices (VADs) pose thrombosis risks to patients. These risks are exacerbated in the small blood conduits of pediatric ventricular assist devices. While commercially available hemocompatible coatings do not yet provide fully inert surfaces that resist clot formation, recent research suggests that self-assembled monolayers (SAMs) of poly(ethylene glycol) (PEG) hold promise in this regard. Unfortunately, these coatings are only weakly bonded to the surface and desorption quickly degrades performance. The aim of this project is to form inert, covalently-bonded PEG monolayers that do not degrade and will extend the usable life of VADs and other implantable devices. This will be accomplished using a novel SAM deposition method based on supercritical carbon dioxide which produces robust monolayers having high graft density and outstanding uniformity. The coatings will be fully characterized using surface analysis methods. Protein adsorption and cellular adhesion will be probed using whole blood assays under controlled flow conditions. Robust Self-Assembled Monolayers for Improved Hemocompatibility Principal Investigator: Brink, Damon Project Narrative Risks of thrombosis formation are significant in ventricular assist devices - particularly in the small blood conduits of pediatric devices. This work seeks to advance the promising poly(ethylene glycol) (PEG) coatings by providing a covalent chemical bond to titanium and alumina substrates. Covalent bonding will enhance the durability of the PEG coatings in the presence of flow induced shear loads. The PEG will be linked with silane functional groups and form a highly uniform self-assembled monolayer (SAM) when deposited via a solution of supercritical carbon dioxide.

描述（由申请人提供）：改善血液相容性的强大自组装单层主要研究者：Brink，Damon Project摘要 /抽象可植入的血液接触医疗设备，例如左心室辅助设备（VADS）姿势血栓形成对患者的风险。这些风险在小儿心室辅助装置的小血管中加剧了。虽然市售的血液相容涂层尚未提供完全抗凝块形成的完全惰性表面，但最近的研究表明，在这方面，聚（乙烯乙二醇）的自组装单层（SAM）（PEG）保持了希望。不幸的是，这些涂层仅薄弱地粘结到表面，并迅速降低了性能。该项目的目的是形成不降级的惰性，共价键入的钉子单层，并将延长VAD和其他可植入设备的可用寿命。这将使用基于超临界二氧化碳的新型SAM沉积方法来实现，该方法产生具有高移植密度和出色均匀性的稳健单层。涂料将使用表面分析方法充分表征。蛋白质吸附和细胞粘附将使用在受控流动条件下的全血测定法进行探测。适用的自组装单层可改善血液相容性主要研究者：Brink，Damon项目的叙事风险在心室辅助设备中很重要，尤其是在儿科设备的小血液导管中。这项工作旨在通过提供与钛和氧化铝底物的共价化学键来推动有希望的聚乙二醇（PEG）涂料。共价键将在存在引起的剪切载荷的情况下增强钉涂层的耐用性。当通过超临界二氧化碳溶液沉积时，PEG将与硅烷官能团相关，并形成高度均匀的自组装单层（SAM）。