Dopamine as a therapeutic agent in stomach cancer

多巴胺作为胃癌的治疗剂

基本信息

批准号：
8616362
负责人：
Sujit Basu
金额：
$ 30.96万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-03-01 至 2018-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8616362
关键词：
8-hydroxy-2&apos -deoxyguanosine Address Adult Agonist Animals Cancer Etiology Cells Cessation of life Clinical Cyclic AMP-Dependent Protein Kinases Cytoprotection DNA Damage Disease Disease Progression Dopamine Epithelial Cells Experimental Designs Gastric Tissue Goals Growth Helicobacter felis Human Incidence Knockout Mice Knowledge Lead Lesion Malignant Neoplasms Measures Mediating Mus Oxidative Stress Pathway interactions Patients Play Pre-Clinical Model Prevention Process Production Reactive Oxygen Species Receptor Signaling Reporting Research Research Design Role Second Primary Cancers Signal Pathway Specificity Staging Stomach System Therapeutic Agents Tissues Treatment Efficacy Wild Type Mouse cancer cell cancer type carcinogenesis combat disease diagnosis dopamine D5 receptor effective therapy efficacy testing in vivo indexing malignant stomach neoplasm neutrophil novel prevent promoter public health relevance receptor receptor function time interval treatment effect tumorigenesis

项目摘要

DESCRIPTION (provided by applicant): Gastric cancer is one of the leading causes of cancer-related deaths in the world. Despite major research and clinical efforts, the results for th treatment of gastric cancer in general have been poor and thus newer and effective therapies are necessary to combat this disease. With reports indicating that substantial amount of DA is produced in normal stomach tissues and DA mediates cytoprotection of gastric epithelial cells by acting through its receptors present in these cells, we therefore postulated that this non-neuronal dopaminergic system in the stomach might also play an important role in gastric tumorigenesis. Thus Aim 1 will investigate the role of non-neuronal stomach dopaminergic system in gastric tumorigenesis, Aim 2 will elucidate the signaling pathway through which dopamine D5 receptors regulate reactive oxygen species in stomach and Aim 3 will determine the therapeutic efficacies of DA D5 receptor agonists in gastric tumorigenesis. The knowledge generated from this study will help to develop newer and effective therapies for this disease, which, as of yet, has no significant treatment.

描述（由申请人提供）：胃癌是世界上癌症相关死亡的主要原因之一。尽管进行了大量的研究和临床努力，但胃癌的治疗结果总体上很差，因此需要更新且有效的疗法来对抗这种疾病。有报道表明，正常胃组织中会产生大量 DA，并且 DA 通过胃上皮细胞中存在的受体发挥作用，介导胃上皮细胞的细胞保护作用，因此我们推测胃中的这种非神经元多巴胺能系统也可能发挥重要作用在胃肿瘤发生中的作用。因此，目标 1 将研究非神经元胃多巴胺能系统在胃肿瘤发生中的作用，目标 2 将阐明多巴胺 D5 受体调节胃中活性氧的信号通路，目标 3 将确定 DA D5 受体激动剂在胃肿瘤发生中的治疗效果。胃肿瘤发生。这项研究产生的知识将有助于为这种疾病开发更新、有效的疗法，迄今为止，这种疾病还没有有效的治疗方法。