Retrospective assessment of radon progeny and pollution effects in COPD

氡子体和 COPD 污染影响的回顾性评估

基本信息

批准号：
9980902
负责人：
ERIC GARSHICK
金额：
$ 20.29万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9980902
关键词：
8-hydroxy-2&apos -deoxyguanosine Address Affect Age Air Pollution Archives Back Biological Markers Blood C-reactive protein Caliber Carbon Black Carcinogens Cause of Death Cessation of life Chronic Obstructive Airway Disease Cities Clinical County DNA Development Disease Equilibrium Exposure to Floor Gases Half-Life Health Home environment Impairment Individual Indoor environment Inflammation Inflammatory Inhalation Interleukin-6 Joints Knowledge Lead Link Lipids Lung Lung diseases Malignant neoplasm of lung Malondialdehyde Massachusetts Measurement Measures National Institute of Environmental Health Sciences Natural Products Noble Gases Nuclear Accidents Older Population Outcome Oxidative Stress Particulate Matter Patients Physical Performance Plasma Pollution Polonium Pulmonary Function Test/Forced Expiratory Volume 1 Radiation Radioactive Radioisotopes Radium Radon Regulation Research Research Design Risk Risk Factors Sampling Soil Testing Time Toxic effect Ultrafine United States Environmental Protection Agency Uranium Urine Veterans Work ambient air pollution base cancer risk cell injury clinically relevant indoor exposure mortality novel oxidative damage particle pulmonary function residence response urinary

项目摘要

Radon (Rn) is a radioactive gas that decays into radiation-emitting progenies capable of inducing cellular damage once inhaled. Residential exposure to Rn is common; however, current health concerns and regulations are based only on its effects as a lung carcinogen. It is not known whether exposure to Rn decay products results in other, non-cancer, adverse health effects, as we propose in chronic obstructive pulmonary disease (COPD) patients. In this exploratory and developmental application, we will assess whether exposure to Rn decay products, as assessed using lead-210 (210Pb), the progeny with the longest half-life, enhances the toxicity (and health effects) of air pollution particles. In 170 Eastern Massachusetts COPD patients, we have previously assessed indoor-home exposures to PM2.5 and black carbon by collecting up to four 7-day samples seasonally over the period of one year. Since 210Pb is in equilibrium with alpha (α)-emitting progeny on archived PM2.5 filter samples, the measurement of total α- radiation emitted from them will permit back-calculation of residential 210Pb levels (as a surrogate measure of Rn progeny) present at the time of sampling. Therefore, we will investigate whether exposure to Rn progeny (as210Pb) modifies (increases) the effect of PM2.5 and black carbon on: 1) plasma biomarkers of systemic inflammation (C-reactive protein and interleukin-6); 2) urinary biomarkers of oxidative damage to lipids (malondialdehyde) and DNA (8-hydroxy-2'-deoxyguanosine); and 3) pulmonary function (FEV1, FVC, and FEV1/FVC). This research design encompasses a strong and novel exposure component linked to clinically relevant and mechanistic outcomes. These are relevant to the health of COPD patients, which is a common disease affecting approximately 11% of the US population older than age 55 years.

ra（RN）是一种放射性气体，它会衰减能够诱导细胞的辐射发射后代吸入一旦损坏。住宅暴露于RN很常见；但是，当前的健康问题和法规仅基于其作为肺癌的作用。尚不清楚是否暴露于RN衰减正如我们在慢性阻塞性肺中提出的那样，产品会导致其他非癌症，不利的健康影响疾病（COPD）患者。在此探索性和发展应用中，我们将评估是否暴露使用Lead-210（210pb）评估的RN衰减产物，最长的半衰期的后代增强了空气污染颗粒的毒性（和健康影响）。在170名马萨诸塞州东部COPD患者中，我们以前已经评估了室内房屋暴露于PM2.5 和黑碳在一年期间最多可季节性收集四个7天样品。自210pb以来在与存档的PM2.5滤波器样品上的α（α）发射进展中的平衡中，测量总α- 从它们发出的辐射将允许对居民进行反对210pb的水平（作为替代测量 RN后代）在抽样时存在。因此，我们将调查是否暴露于RN后代（AS210pb）修改（增加）PM2.5和黑碳对：1）全身等离子体生物标志物炎症（C反应蛋白和白介素-6）； 2）对脂质氧化损伤的尿生物标志物（丙二醛）和DNA（8-羟基-2'-脱氧鸟苷）； 3）肺功能（FEV1，FVC和 FEV1/FVC）。这项研究设计涵盖了与临床上相关的强大而新颖的暴露组件相关和机械结果。这些与COPD患者的健康有关，这很常见疾病影响约11％的55岁以上的美国人口。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Geomagnetic disturbances reduce heart rate variability in the Normative Aging Study.

DOI：
10.1016/j.scitotenv.2022.156235
发表时间：
2022-09-15
期刊：
SCIENCE OF THE TOTAL ENVIRONMENT
影响因子：
9.8
作者：
Vieira, Carolina L. Zilli;Chen, Kelly;Garshick, Eric;Liu, Man;Vokonas, Pantel;Ljungman, Petter;Schwartz, Joel;Koutrakis, Petros
通讯作者：
Koutrakis, Petros

The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.

DOI：
10.1371/journal.pone.0268700
发表时间：
2022
期刊：
PloS one
影响因子：
3.7
作者：
通讯作者：

Solar and geomagnetic activity reduces pulmonary function and enhances particulate pollution effects.

DOI：
10.1016/j.scitotenv.2022.156434
发表时间：
2022-09-10
期刊：
SCIENCE OF THE TOTAL ENVIRONMENT
影响因子：
9.8
作者：
Anand, Kritika;Vieira, Carolina L. Z.;Garshick, Eric;Wang, Veronica;Blomberg, Annelise;Gold, Diane R.;Schwartz, Joel;Vokonas, Pantel;Koutrakis, Petros
通讯作者：
Koutrakis, Petros