Retrospective assessment of radon progeny and pollution effects in COPD

氡子体和 COPD 污染影响的回顾性评估

基本信息

批准号：
9980902
负责人：
ERIC GARSHICK
金额：
$ 20.29万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9980902
关键词：
8-hydroxy-2&apos -deoxyguanosine Address Affect Age Air Pollution Archives Back Biological Markers Blood C-reactive protein Caliber Carbon Black Carcinogens Cause of Death Cessation of life Chronic Obstructive Airway Disease Cities Clinical County DNA Development Disease Equilibrium Exposure to Floor Gases Half-Life Health Home environment Impairment Individual Indoor environment Inflammation Inflammatory Inhalation Interleukin-6 Joints Knowledge Lead Link Lipids Lung Lung diseases Malignant neoplasm of lung Malondialdehyde Massachusetts Measurement Measures National Institute of Environmental Health Sciences Natural Products Noble Gases Nuclear Accidents Older Population Outcome Oxidative Stress Particulate Matter Patients Physical Performance Plasma Pollution Polonium Pulmonary Function Test/Forced Expiratory Volume 1 Radiation Radioactive Radioisotopes Radium Radon Regulation Research Research Design Risk Risk Factors Sampling Soil Testing Time Toxic effect Ultrafine United States Environmental Protection Agency Uranium Urine Veterans Work ambient air pollution base cancer risk cell injury clinically relevant indoor exposure mortality novel oxidative damage particle pulmonary function residence response urinary

项目摘要

Radon (Rn) is a radioactive gas that decays into radiation-emitting progenies capable of inducing cellular damage once inhaled. Residential exposure to Rn is common; however, current health concerns and regulations are based only on its effects as a lung carcinogen. It is not known whether exposure to Rn decay products results in other, non-cancer, adverse health effects, as we propose in chronic obstructive pulmonary disease (COPD) patients. In this exploratory and developmental application, we will assess whether exposure to Rn decay products, as assessed using lead-210 (210Pb), the progeny with the longest half-life, enhances the toxicity (and health effects) of air pollution particles. In 170 Eastern Massachusetts COPD patients, we have previously assessed indoor-home exposures to PM2.5 and black carbon by collecting up to four 7-day samples seasonally over the period of one year. Since 210Pb is in equilibrium with alpha (α)-emitting progeny on archived PM2.5 filter samples, the measurement of total α- radiation emitted from them will permit back-calculation of residential 210Pb levels (as a surrogate measure of Rn progeny) present at the time of sampling. Therefore, we will investigate whether exposure to Rn progeny (as210Pb) modifies (increases) the effect of PM2.5 and black carbon on: 1) plasma biomarkers of systemic inflammation (C-reactive protein and interleukin-6); 2) urinary biomarkers of oxidative damage to lipids (malondialdehyde) and DNA (8-hydroxy-2'-deoxyguanosine); and 3) pulmonary function (FEV1, FVC, and FEV1/FVC). This research design encompasses a strong and novel exposure component linked to clinically relevant and mechanistic outcomes. These are relevant to the health of COPD patients, which is a common disease affecting approximately 11% of the US population older than age 55 years.

氡 (Rn) 是一种放射性气体，可衰变成能够诱导细胞产生辐射的子体。然而，吸入 Rn 后造成的损害很常见；法规仅基于其作为肺癌致癌物的影响。尚不清楚接触 Rn 是否会衰变。正如我们在慢性阻塞性肺疾病中所建议的那样，产品会导致其他非癌症的不良健康影响在这个探索性和开发性应用中，我们将评估是否暴露于慢性阻塞性肺病（COPD）患者。与 Rn 衰变产物相比，使用具有最长半衰期的铅 210 (210Pb) 进行评估，增强了空气污染颗粒的毒性（和健康影响）。我们之前评估了马萨诸塞州东部 170 名慢性阻塞性肺病患者的室内 PM2.5 暴露情况由于 210Pb 是在一年内季节性采集最多 4 个 7 天样本。在存档的 PM2.5 过滤器样品上与 α (α) 发射子代保持平衡，测量总 α- 它们发出的辐射将允许反算住宅 210Pb 水平（作为 Rn 后代）在采样时存在，因此，我们将调查是否暴露于 Rn 后代。 (as210Pb) 改变（增加）PM2.5 和黑碳对以下方面的影响：1) 全身血浆生物标志物炎症（C 反应蛋白和白细胞介素 6）；脂质氧化损伤的尿液生物标志物（丙二醛）和 DNA（8-羟基-2'-脱氧鸟苷）；3) 肺功能（FEV1、FVC 和） FEV1/FVC）该研究设计包含与临床相关的强大而新颖的暴露成分。这些结果与慢性阻塞性肺病患者的健康有关，这是常见的。该疾病影响约 11% 的 55 岁以上美国人口。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Geomagnetic disturbances reduce heart rate variability in the Normative Aging Study.

DOI：
10.1016/j.scitotenv.2022.156235
发表时间：
2022-09-15
期刊：
SCIENCE OF THE TOTAL ENVIRONMENT
影响因子：
9.8
作者：
Vieira, Carolina L. Zilli;Chen, Kelly;Garshick, Eric;Liu, Man;Vokonas, Pantel;Ljungman, Petter;Schwartz, Joel;Koutrakis, Petros
通讯作者：
Koutrakis, Petros

The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.

DOI：
10.1371/journal.pone.0268700
发表时间：
2022
期刊：
PloS one
影响因子：
3.7
作者：
通讯作者：

Solar and geomagnetic activity reduces pulmonary function and enhances particulate pollution effects.

DOI：
10.1016/j.scitotenv.2022.156434
发表时间：
2022-09-10
期刊：
SCIENCE OF THE TOTAL ENVIRONMENT
影响因子：
9.8
作者：
Anand, Kritika;Vieira, Carolina L. Z.;Garshick, Eric;Wang, Veronica;Blomberg, Annelise;Gold, Diane R.;Schwartz, Joel;Vokonas, Pantel;Koutrakis, Petros
通讯作者：
Koutrakis, Petros