MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT)

MRI 评估患者是否适合心脏再同步治疗 (CRT)

• 批准号: 8916207
• 负责人: Leon Axel
• 金额: $ 38.95万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8916207
• 关键词: Apical; Bundle-Branch Block; Cardiac; Cardiovascular system; Caring; Clinical; Computer Simulation; Data; Deterioration; Development; Devices; EFRAC; Echocardiography; Evaluation; Failure; Functional disorder; Future; Gadolinium; Goals; Health; Heart; Heart failure; Image; Image Analysis; Individual; Lateral; Left; Left ventricular structure; Location; Logistic Regressions; Magnetic Resonance Imaging; Mechanics; Methods; Modeling; Motion; Myocardial Contraction; Outcome; Patient Selection; Patients; Pattern; Performance; Procedures; Prospective Studies; Public Health; Regression Analysis; Relative (related person); Research; Role; Series; Severities; Symptoms; Testing; United States; Validation; Ventricular; Weight; aortic valve; base; conventional therapy; follow-up; functional disability; gadolinium oxide; heart function; implantation; improved; response

DESCRIPTION (provided by applicant): Heart failure is a major public health problem, with limited treatment options. Many patients with heart failure develop mechanical dyssynchrony, with associated further deterioration in heart function. Some patients with heart failure and dyssynchrony benefit from cardiac resynchronization therapy (CRT), but a third or more of heart failure patients selected for treatment with CRT with conventional criteria fail to benefit significantly from it. The primary goals of this project are: 1) development and evaluation of magnetic resonance imaging (MRI) and image analysis methods to better predict outcome of the use of cardiac resynchronization therapy (CRT) for heart failure with dyssynchrony, and 2) use of the imaging-derived data for computer modeling of the effects of the dyssynchrony on cardiac function and its response to CRT. As heart failure is an important clinical condition, and as current means used to predict response to CRT have limited accuracy, this project is potentially clinically very significant.

描述（由申请人提供）：心力衰竭是一个主要的公共卫生问题，治疗方案有限。许多心力衰竭患者会出现机械性障碍，并导致心脏功能进一步恶化。一些患有心力衰竭和异议障碍的患者从心脏重新同步疗法（CRT）中受益，但第三名或更多的心力衰竭患者被选为具有常规标准的CRT治疗，无法从中受益匪浅。该项目的主要目标是：1）对磁共振成像（MRI）和图像分析方法的开发和评估，以更好地预测使用心力衰竭使用心力衰竭的心力衰竭和使用功能障碍和2）使用Imaging-Data Data date demanter-dedaig vernssynchrony对Cardiac对Cardiac对Cardiac对Crt响应的效果的效果的结果。由于心力衰竭是重要的临床状况，并且由于用于预测CRT反应的当前手段的准确性有限，因此该项目在临床上可能非常重要。