Development and Evaluation of MRI Methods to Assess Diastolic Function

评估舒张功能的 MRI 方法的开发和评估

• 批准号: 8290310
• 负责人: Leon Axel
• 金额: $ 25.35万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8290310
• 关键词: Affect; Asses; Cardiac; Caring; Clinical; Data; Development; Diagnosis; Diastole; Diastolic heart failure; EFRAC; Effectiveness; Etiology; Evaluation; Functional disorder; Heart; Heart Diseases; Heart failure; Image; Image Analysis; Investigation; Location; Magnetic Resonance Imaging; Measurement; Measures; Medical Imaging; Methods; Morbidity - disease rate; Motion; Myocardial; Myocardium; Normal Range; Patient Care; Patients; Phase; Public Health; Reference Standards; Relaxation; Reporting; Research; Risk; Role; Sampling; Severities; Source; Symptoms; System; Systole; Western World; base; design; disability; functional disability; heart function; imaging modality; improved; mortality; novel; research clinical testing; response; tool

DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed research is to improve the ability to care for patients with heart failure, by providing better means to evaluate their heart function with magnetic resonance imaging (MRI) studies. MRI is a powerful medical imaging method, with a growing role in the care of heart patients. However, it has still been relatively little applied to the evaluation of diastole, the relaxation phase of the cardiac cycle, which can be affected before systole, the more commonly evaluated contraction phase of the cardiac cycle. The Specific Aims of the proposed research are to: 1) further develop technical methods for evaluation of diastole through tracking the motion of the atrioventricular junction, and 2) evaluate these methods in a sample of patients with heart failure and diastolic dysfunction and in matched control subjects. If successful, the proposed research has the potential to provide an improved means to assess diastolic function with MRI, which would be useful in caring for many patients who have or are at risk for developing heart failure.

描述（由申请人提供）：拟议的研究的广泛长期目标是通过提供更好的手段来通过磁共振成像（MRI）研究来评估其心脏功能，以提高护理心力衰竭患者的能力。 MRI是一种强大的医学成像方法，在心脏病患者的护理中发挥了越来越多的作用。但是，它仍然相对较少地应用于舒张期的评估，这是心脏周期的弛豫阶段，这可能会在收缩之前受到影响，这是心脏周期的更常见的收缩阶段。拟议的研究的具体目的是：1）进一步开发技术方法，通过跟踪心室交界的运动来评估舒张期，以及2）在心力衰竭和舒张功能障碍和匹配的对照受试者的样本中评估这些方法。如果成功的话，拟议的研究有可能提供改进的方法来评估MRI的舒张功能，这对于许多患有或有患心力衰竭风险的患者的照顾将很有用。

项目成果

Evaluation of diastolic function by three-dimensional volume tracking of the mitral annulus with cardiovascular magnetic resonance: comparison with tissue Doppler imaging.

• DOI: 10.1186/s12968-014-0071-3
• 发表时间: 2014-09-20
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Wu V;Chyou JY;Chung S;Bhagavatula S;Axel L
• 通讯作者: Axel L