Development and Evaluation of MRI Methods to Assess Diastolic Function

评估舒张功能的 MRI 方法的开发和评估

• 批准号: 8093461
• 负责人: Leon Axel
• 金额: $ 21.13万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8093461
• 关键词: Affect; Asses; Cardiac; Caring; Clinical; Data; Development; Diagnosis; Diastole; Diastolic heart failure; EFRAC; Effectiveness; Etiology; Evaluation; Functional disorder; Heart; Heart Diseases; Heart failure; Image; Image Analysis; Investigation; Location; Magnetic Resonance Imaging; Measurement; Measures; Medical Imaging; Methods; Morbidity - disease rate; Motion; Myocardial; Myocardium; Normal Range; Patient Care; Patients; Phase; Public Health; Reference Standards; Relaxation; Reporting; Research; Risk; Role; Sampling; Severities; Source; Symptoms; System; Systole; Western World; base; design; disability; functional disability; heart function; imaging modality; improved; mortality; novel; research clinical testing; response; tool

DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed research is to improve the ability to care for patients with heart failure, by providing better means to evaluate their heart function with magnetic resonance imaging (MRI) studies. MRI is a powerful medical imaging method, with a growing role in the care of heart patients. However, it has still been relatively little applied to the evaluation of diastole, the relaxation phase of the cardiac cycle, which can be affected before systole, the more commonly evaluated contraction phase of the cardiac cycle. The Specific Aims of the proposed research are to: 1) further develop technical methods for evaluation of diastole through tracking the motion of the atrioventricular junction, and 2) evaluate these methods in a sample of patients with heart failure and diastolic dysfunction and in matched control subjects. If successful, the proposed research has the potential to provide an improved means to assess diastolic function with MRI, which would be useful in caring for many patients who have or are at risk for developing heart failure. PUBLIC HEALTH RELEVANCE: Assessment of diastolic function is an important part of the management of patients with heart failure, a major public health problem. Magnetic resonance imaging (MRI) has had a growing role in cardiac imaging, but its use for assessing diastolic function is still limited. The overall aim of this project is the development and initial evaluation of new methods for evaluating diastolic function with MRI systems; if successful, this could provide a way to improve the management of heart failure patients.

描述（由申请人提供）：拟议研究的广泛、长期目标是通过磁共振成像（MRI）研究提供更好的方法来评估心力衰竭患者的心脏功能，从而提高护理心力衰竭患者的能力。 MRI 是一种强大的医学成像方法，在心脏病患者的护理中发挥着越来越重要的作用。然而，它仍然相对较少应用于舒张期（心动周期的松弛阶段）的评估，舒张期可能会在收缩期（心动周期的更常见评估的收缩阶段）之前受到影响。拟议研究的具体目标是：1）通过跟踪房室交界处的运动，进一步开发评估舒张期的技术方法，2）在患有心力衰竭和舒张功能障碍的患者样本和匹配对照中评估这些方法科目。如果成功，拟议的研究有可能提供一种改进的 MRI 评估舒张功能的方法，这将有助于护理许多患有心力衰竭或有发生心力衰竭风险的患者。 公共卫生相关性：舒张功能评估是心力衰竭患者治疗的重要组成部分，心力衰竭是一个重大的公共卫生问题。磁共振成像 (MRI) 在心脏成像中的作用越来越大，但其在评估舒张功能方面的应用仍然有限。该项目的总体目标是开发和初步评估使用 MRI 系统评估舒张功能的新方法；如果成功，这可以为改善心力衰竭患者的治疗提供一种方法。