Quantitative Myocardial Perfusion in Assessment with MRI

MRI 评估中的定量心肌灌注

• 批准号: 7026023
• 负责人: Leon Axel
• 金额: $ 54.19万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7026023
• 关键词: angiography; bioimaging /biomedical imaging; blood flow measurement; catheterization; clinical research; computed axial tomography; contrast media; coronary disorder; heart circulation; heart imaging /visualization /scanning; human subject; image processing; magnetic resonance imaging; method development; myocardial infarction; myocardium; parallel processing; patient oriented research; phantom model; radionuclide imaging /scanning

Heart disease is the leading cause of morbidity and mortality in the Western World. As this is mostly related to disorders of the blood supply to the heart, it is very important to be able to assess the perfusion of the heart wall. Conventional methods for assessing myocardial perfusion have many limitations, including relatively low resolution and poor ability to provide quantitative data. Magnetic resonance imaging (MRI) of the "first-pass" kinetics of contrast enhancement by a bolus injection of contrast agent is a very promising method for noninvasive assessment of myocardial perfusion, with higher resolution than conventional radionuclide imaging methods. However, current approaches to MRI perfusion studies have only been "semiquantitative", due to several technical difficulties. We have been achieving very encouraging initial results in making absolute measurements of regional myocardial perfusion, using novel MRI methods that we have designed to overcome the limitations of conventional MRI approaches. In the proposed research, we will further develop our MRI methods, and the associated image analysis methods, for quantitatively measuring myocardial perfusion. We will perform a series of studies on normal subjects to establish the expected range of variability of the results. We will also perform a series of studies of patients with coronary artery disease, comparing the results of our MRI methods with those of conventional methods used to assess the blood supply to the heart, including radionuclide imaging, CT angiography and conventional cardiac catheterization (including invasive measures of flow reserve). The significance of the proposed work is its potential to achieve more accurate and higher resolution assessments of blood flow to the heart wall than current conventional methods can provide. This would be very useful for aiding treatment decisions and for following the results of therapy in patients with ischemic heart disease, a common and serious clinical condition. The quantitative MRI methods we propose to develop for the assessment of cardiac vascular disease may also be applicable to assessment of the perfusion of other important organs, such as the brain, which is subject to stroke, and in other important disease processes, such as cancer, where the disease evolution may be related to blood flow.

心脏病是西方世界发病率和死亡率的主要原因。由于这主要是 与心脏血液供应障碍有关，能够评估心脏的灌注非常重要 心壁。评估心肌灌注的传统方法有许多局限性，包括 分辨率相对较低，提供定量数据的能力较差。磁共振成像 (MRI) 通过推注造影剂来增强对比度的“首过”动力学是一种非常有前途的方法 无创评估心肌灌注的方法，比传统方法具有更高的分辨率 放射性核素成像方法。然而，目前 MRI 灌注研究的方法只是“半定量”， 由于一些技术困难。 我们在对区域的绝对测量方面取得了非常令人鼓舞的初步成果 心肌灌注，使用我们设计来克服局限性的新型 MRI 方法 传统的 MRI 方法。在拟议的研究中，我们将进一步发展我们的 MRI 方法， 相关的图像分析方法，用于定量测量心肌灌注。我们将执行一个 对正常受试者进行的一系列研究，以确定结果的预期变异范围。我们也会 对冠状动脉疾病患者进行一系列研究，比较我们的 MRI 结果 方法与用于评估心脏血液供应的传统方法相同，包括 放射性核素显像、CT血管造影和常规心导管检查（包括侵入性措施） 流量储备）。 这项工作的意义在于它有可能实现更准确和更高分辨率 与目前的传统方法相比，可以对流向心壁的血流量进行评估。这将是 对于帮助做出治疗决策和跟踪缺血性患者的治疗结果非常有用 心脏病，一种常见且严重的临床疾病。我们建议的定量 MRI 方法 为评估心血管疾病而开发的方法也可能适用于评估 其他重要器官的灌注，例如易患中风的大脑，以及其他重要器官的灌注 疾病过程，例如癌症，其中疾病的演变可能与血流有关。