Quantitative Myocardial Perfusion in Assessment with MRI

MRI 评估中的定量心肌灌注

• 批准号: 7026023
• 负责人: Leon Axel
• 金额: $ 54.19万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7026023
• 关键词: angiography; bioimaging /biomedical imaging; blood flow measurement; catheterization; clinical research; computed axial tomography; contrast media; coronary disorder; heart circulation; heart imaging /visualization /scanning; human subject; image processing; magnetic resonance imaging; method development; myocardial infarction; myocardium; parallel processing; patient oriented research; phantom model; radionuclide imaging /scanning

Heart disease is the leading cause of morbidity and mortality in the Western World. As this is mostly related to disorders of the blood supply to the heart, it is very important to be able to assess the perfusion of the heart wall. Conventional methods for assessing myocardial perfusion have many limitations, including relatively low resolution and poor ability to provide quantitative data. Magnetic resonance imaging (MRI) of the "first-pass" kinetics of contrast enhancement by a bolus injection of contrast agent is a very promising method for noninvasive assessment of myocardial perfusion, with higher resolution than conventional radionuclide imaging methods. However, current approaches to MRI perfusion studies have only been "semiquantitative", due to several technical difficulties. We have been achieving very encouraging initial results in making absolute measurements of regional myocardial perfusion, using novel MRI methods that we have designed to overcome the limitations of conventional MRI approaches. In the proposed research, we will further develop our MRI methods, and the associated image analysis methods, for quantitatively measuring myocardial perfusion. We will perform a series of studies on normal subjects to establish the expected range of variability of the results. We will also perform a series of studies of patients with coronary artery disease, comparing the results of our MRI methods with those of conventional methods used to assess the blood supply to the heart, including radionuclide imaging, CT angiography and conventional cardiac catheterization (including invasive measures of flow reserve). The significance of the proposed work is its potential to achieve more accurate and higher resolution assessments of blood flow to the heart wall than current conventional methods can provide. This would be very useful for aiding treatment decisions and for following the results of therapy in patients with ischemic heart disease, a common and serious clinical condition. The quantitative MRI methods we propose to develop for the assessment of cardiac vascular disease may also be applicable to assessment of the perfusion of other important organs, such as the brain, which is subject to stroke, and in other important disease processes, such as cancer, where the disease evolution may be related to blood flow.

心脏病是西方世界发病和死亡率的主要原因。因为这主要是 与心脏的血液供应障碍有关，能够评估灌注非常重要 心墙。评估心肌灌注的常规方法有许多局限性，包括 分辨率相对较低，提供定量数据的能力差。磁共振成像（MRI） 向对比剂注射推注的对比增强的“第一通通”动力学是非常有前途的 无创评估心肌灌注的方法，分辨率高于常规 放射性核素成像方法。但是，当前的MRI灌注研究方法只是“半定量”， 由于几个技术困难。 在对区域的绝对测量中，我们一直在取得非常令人鼓舞的初步结果 心肌灌注，使用我们旨在克服局限性的新型MRI方法 常规MRI接近。在拟议的研究中，我们将进一步开发我们的MRI方法，并 相关的图像分析方法，用于定量测量心肌灌注。我们将执行 关于正常受试者的一系列研究，以建立结果的预期差异范围。我们也会 对冠状动脉疾病患者进行一系列研究，比较我们的MRI的结果 使用用于评估心脏血液供应的常规方法的方法，包括 放射性核素成像，CT血管造影和常规心脏导管插入术（包括侵入性措施 流动储备）。 拟议工作的意义在于其实现更准确和更高分辨率的潜力 对流向心脏壁的血流的评估比当前常规方法可以提供的评估。这是 对于帮助治疗决策和遵循缺血患者的治疗结果非常有用 心脏病，一种常见且严重的临床状况。我们建议的定量MRI方法 开发评估心脏血管疾病也可能适用于评估 其他重要器官的灌注，例如大脑，可能会中风和其他重要的器官 疾病过程，例如癌症，疾病进化可能与血流有关。