A MICRO-CT SCANNER FOR IN VIVO MOUSE IMAGING AND EX VIVO MONKEY TISSUE IMAGING

用于小鼠体内成像和猴体外组织成像的微型 CT 扫描仪

• 批准号: 8357873
• 负责人: ELIOT R SPINDEL
• 金额: $ 5.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357873
• 关键词: Advisory Committees; Animals; Area; Automobile Driving; Basic Science; Cities; Clinical Research; Data Analyses; Developmental Biology; Doctor of Philosophy; Ensure; Funding; Grant; Health; Hour; Human; Image; Lung diseases; Magnetic Resonance Imaging; Metabolic; Minor; Mission; Modeling; Monkeys; Mus; National Center for Research Resources; Obesity; Oregon; Placental Insufficiency; Primates; Principal Investigator; Radiology Specialty; Regulation; Reproductive Biology; Research; Research Infrastructure; Research Support; Resources; Scanning; Source; System; Time; Tissues; Training; United States National Institutes of Health; Universities; cost; experience; in vivo; oncology; pre-clinical

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is a grant to purchase a micro-CT scanner for in vivo mouse imaging and ex vivo monkey tissue imaging at the. The mission of the ONPRC is to move from basic science to pre-clinical monkey models to clinical research. As such this scanner which will allow both in vivo scanning of mice and ex vivo scanning of monkey tissues is uniquely suited to the mission of the ONPRC. The research supported by the scanner will support key research areas of the ONPRC including reproductive biology, metabolic regulation, developmental biology and oncology. There will be 5 major users and 6 minor users. The major users will focus on oncofertility, obesity, lung disease and placental insufficiency, all areas of major importance to human health. Use of the system will be directed by a PhD biophysicist who also directs the ONPRC MRI core. A highly experienced small animal radiology technician will oversee day to day use and be responsible for training new users. An advisory committee of users, local, and national micro-CT experts will assist with administration and ensure appropriate training and data analysis. The scanner will fill a major need as there is no micro-CT scanner in the city of Portland, with the closest scanner located at Oregon State University, two hours driving time from Portland.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 这笔赠款用于购买微型 CT 扫描仪，用于小鼠体内成像和猴子离体组织成像。 ONPRC 的使命是从基础科学转向临床前猴子模型再到临床研究。因此，这款扫描仪既可以对小鼠进行体内扫描，又可以对猴子组织进行离体扫描，非常适合 ONPRC 的使命。该扫描仪支持的研究将支持 ONPRC 的关键研究领域，包括生殖生物学、代谢调节、发育生物学和肿瘤学。将有 5 个主要用户和 6 个次要用户。主要用户将关注不孕不育、肥胖、肺部疾病和胎盘功能不全等对人类健康至关重要的领域。该系统的使用将由一位博士生物物理学家指导，他也指导 ONPRC MRI 核心。经验丰富的小动物放射技术人员将监督日常使用并负责培训新用户。由用户、当地和国家微型 CT 专家组成的咨询委员会将协助管理并确保适当的培训和数据分析。该扫描仪将满足主要需求，因为波特兰市没有微型 CT 扫描仪，最近的扫描仪位于俄勒冈州立大学，距离波特兰有两个小时的车程。