A micro-CT scanner for in vivo mouse imaging and ex vivo monkey tissue imaging

用于小鼠体内成像和猴子离体组织成像的微型 CT 扫描仪

• 批准号: 7793935
• 负责人: ELIOT R SPINDEL
• 金额: $ 34.17万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-20 至 2011-07-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793935
• 关键词: Advisory Committees; Animals; Area; Automobile Driving; Basic Science; Caliber; Cancer Patient; Cardiovascular system; Cities; Clinical Research; Contract Services; Data Analyses; Developmental Biology; Doctor of Philosophy; Endocrinology; Ensure; Fertility; Fetal Development; Funding; Health; Health Sciences; Hour; Housing; Human; Human Resources; Image; Institution; Lung diseases; Magnetic Resonance Imaging; Metabolic; Minor; Mission; Modeling; Monkeys; Mus; Obesity; Oregon; Physiological; Placental Insufficiency; Pregnancy; Primates; Public Health; Radiology Specialty; Regulation; Reproductive Biology; Research; Research Support; Resolution; Sampling; Scanning; Smoking; System; Time; Tissues; Training; Universities; combat; cost; experience; flexibility; in vivo; instrument; oncology; pre-clinical; prevent; public health relevance

DESCRIPTION (provided by applicant): This is a request for funds to purchase a Skyscan 1066 micro-CT for in vivo mouse imaging and ex vivo monkey tissue imaging at the Oregon National Primate Research Center (ONPRC) and Oregon Health & Science University (OHSU). The mission of the ONPRC is to move from basic science to pre-clinical monkey models to clinical research. As such this scanner which will allow both in vivo scanning of mice and ex vivo scanning of monkey tissues is uniquely suited to the mission of the ONPRC. We evaluated micro-CT scanners from Skyscan, Scanco, GE and Siemens. We chose the Skyscan 1076 because it has the greatest versatility in terms of high resolution (9 microns) and large maximum sample diameter (68 mm) for ex vivo scanning of monkey tissues and flexible resolution, scanning size and physiologic control and gating capacity for in vivo scanning. The research supported by the scanner will support key research areas of the ONPRC including reproductive biology, metabolic regulation, developmental biology and oncology. The scanner will also support cardiovascular research, oncology and endocrinology research by the ONPRC's host institution, OHSU. There will be 5 major users and 6 minor users. The major users will focus on oncofertility, obesity, lung disease and placental insufficiency, all areas of major importance to human health. Use of the system will be directed by a PhD biophysicist who also directs the ONPRC MRI core. A highly experienced small animal radiology technician will oversee day to day use and be responsible for training new users. An advisory committee of users, local, and national micro-CT experts will assist with administration and ensure appropriate training and data analysis. Strong institutional support will provide needed renovations to house the scanner, cover service contract costs and cover personnel costs of the technician and physicist. The scanner will fill a major need as there is no micro-CT scanner in the city of Portland, with the closest scanner located at Oregon State University, two hours driving time from Portland. PUBLIC HEALTH RELEVANCE: This instrument will support research on preserving fertility in cancer patients, research on combating obesity, research on preventing the effects of smoking during pregnancy on fetal development and research on placental problems during pregnancy. These are all major public health problems whose treatment will be significantly helped by the micro-CT scanner requested in this application.

描述（由申请人提供）：这是一份资金申请，用于在俄勒冈国家灵长类动物研究中心 (ONPRC) 和俄勒冈健康与科学大学 (OHSU) 购买 Skyscan 1066 微型 CT，用于小鼠体内成像和猴子离体组织成像）。 ONPRC 的使命是从基础科学转向临床前猴子模型再到临床研究。因此，这款扫描仪既可以对小鼠进行体内扫描，又可以对猴子组织进行离体扫描，非常适合 ONPRC 的使命。我们评估了 Skyscan、Scanco、GE 和西门子的微型 CT 扫描仪。我们选择 Skyscan 1076 是因为它在高分辨率（9 微米）和大最大样本直径（68 毫米）方面具有最大的多功能性，可用于猴组织的离体扫描，并且具有灵活的分辨率、扫描尺寸以及生理控制和门控能力活体扫描。该扫描仪支持的研究将支持 ONPRC 的关键研究领域，包括生殖生物学、代谢调节、发育生物学和肿瘤学。该扫描仪还将支持 ONPRC 的主办机构 OHSU 的心血管研究、肿瘤学和内分泌学研究。将有 5 个主要用户和 6 个次要用户。主要用户将关注不孕不育、肥胖、肺部疾病和胎盘功能不全等对人类健康至关重要的领域。该系统的使用将由一位博士生物物理学家指导，他也指导 ONPRC MRI 核心。经验丰富的小动物放射技术人员将监督日常使用并负责培训新用户。由用户、当地和国家微型 CT 专家组成的咨询委员会将协助管理并确保适当的培训和数据分析。强大的机构支持将提供扫描仪所需的翻新、支付服务合同成本以及技术人员和物理学家的人员成本。该扫描仪将满足主要需求，因为波特兰市没有微型 CT 扫描仪，最近的扫描仪位于俄勒冈州立大学，距离波特兰有两个小时的车程。 公共健康相关性：该工具将支持癌症患者保留生育能力的研究、对抗肥胖的研究、预防怀孕期间吸烟对胎儿发育影响的研究以及怀孕期间胎盘问题的研究。这些都是重大的公共卫生问题，本申请中要求的微型 CT 扫描仪将对这些问题的治疗有很大帮助。