Changes in reading networks of dyslexia as measured by multimodal imaging

通过多模态成像测量阅读障碍阅读网络的变化

• 批准号: 8731960
• 负责人: KRISTI A CLARK
• 金额: $ 24.19万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-10 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8731960
• 关键词: 12 year old; 6 year old; Address; Affect; Age; Area; Award; Behavior Therapy; Behavioral; Brain; Brain imaging; Brain region; California; Child; Childhood; Clinical; Cognitive; Control Groups; Data; Data Set; Development; Developmental reading disorder; Diffusion; Dyslexia; Education; Educational Intervention; Faculty; Feeling; Future; Goals; Growth; Image; Image Analysis; Individual; Intervention; Knowledge; Learning; Longitudinal Studies; Los Angeles; Mentors; Mentorship; Methods; Nature; Neurobiology; Neuropsychological Tests; Neurosciences; Norway; Orthography; Parents; Pathway interactions; Performance; Phase; Philosophy; Plastics; Population; Positioning Attribute; Postdoctoral Fellow; Psychological Theory; Public Health; Reader; Reading; Reading Disorder; Research; Research Personnel; Sampling; Schools; Socioeconomic Status; Structure; System; Testing; Thick; Time; Training; United States National Institutes of Health; Universities; Variant; Work; Writing; abstracting; aged; base; career; cognitive neuroscience; cohort; design; experience; insight; literacy; meetings; neuroimaging; outcome forecast; phonology; remediation; research study; skills; theories

Project Summary/Abstract This K99/R00 award will support the candidate's goal for developing a career as an independent researcher in the field of developmental neuroscience, particularly with regard to the study of dyslexia. The candidate is currently a postdoctoral fellow with considerable research experience in functional and diffusion neuroimaging and has strong computational skills. Training will take place primarily at the University of California, Los Angeles (UCLA) under the primary mentorship of Dr. Arthur Toga, an expert on basic neuroimaging studies, and with the guidance of co-mentor Dr. Katherine Narr, an expert on clinical neuroimaging studies. Additional training will take place at the University of Southern California (USC) under the mentorship of co-mentor Dr. Franklin Manis, an expert on the psychological theories of dyslexia. The training component of this award will focus on three main areas: 1) expanding the candidate's general knowledge about developmental cognitive neuroscience and more specific knowledge regarding current theories relating to dyslexia; 2) developing practical skills in acquiring and integrating multimodal neuroimaging data in pediatric cohorts; and 3) developing skills in administering and interpreting the results of neuropsychological tests. Research conducted during the mentored phase of this award will take advantage of an existing longitudinal imaging dataset obtained from prominent investigators in the field of dyslexia to address important hypotheses concerning the systems-level neurobiological correlates of dyslexia prior to reading age or that occur in association with brain maturation during childhood in subjects followed prospectively. Acquisition of structural, functional and diffusion imaging data from new groups of children with dyslexia and reading-level and age-matched controls will be a focus during the R00 phase. During this phase, the candidate will use this independent sample to further develop and apply highly sophisticated multimodal computational image analysis methods to dissociate disturbances in distinct and/or overlapping brain networks that will specifically address the precise nature of reading and writing disturbances in dyslexia. The training plan is designed to fill the gaps in the candidate's previous academic career so that she can successfully attain a tenure-track faculty position at a research university. The research plan is designed to provide insight into the brain mechanisms underlying dyslexia that may help direct more effective behavioral remediation in the future. This work may form an important basis for future studies using cross-modal brain imaging markers to evaluate such remediation approaches in dyslexia.

项目摘要/摘要 这项K99/R00奖将支持候选人的目标，以发展成独立研究人员的职业 发育神经科学领域，特别是在阅读障碍研究方面。候选人是 目前是博士后研究员，在功能和扩散神经影像学方面具有丰富的研究经验 并具有强大的计算能力。培训将主要在加利福尼亚大学Los举行 Angeles（UCLA）在Arthur Toga博士的主要指导下，基础神经影像学专家， 并在临床神经影像学专家Katherine Narr博士的指导下。额外的 培训将在Co-Mentor博士的指导下在南加州大学（USC）举行。 富兰克林·曼尼斯（Franklin Manis），阅读障碍心理理论的专家。该奖项的培训部分将 专注于三个主要领域：1）扩大候选人对发展认知的一般知识 神经科学和有关与阅读障碍有关的当前理论的更具体知识； 2）发展 在儿科队列中获取和整合多模式神经影像数据的实践技能； 3） 开发管理和解释神经心理学测试结果的技能。研究进行了 在该奖项的指导阶段，将利用现有的纵向成像数据集 从阅读障碍领域的著名研究者获得的，以解决有关 在阅读年龄之前或与大脑有关的系统级神经生物学相关性 童年期间的成熟受试者的成熟。获取结构，功能和 来自新的患有阅读障碍和阅读级和年龄匹配的对照组的新组的扩散成像数据 在R00阶段将成为重点。在此阶段，候选人将使用此独立样本来 进一步开发并应用高度复杂的多模式计算图像分析方法来解离 在不同的和/或重叠的大脑网络中的干扰，这些网络将专门解决 阅读和写作障碍。培训计划旨在填补候选人的空白 以前的学术职业，以便她可以在研究中成功获得终身任职教师职位 大学。该研究计划旨在洞悉脑阅读障碍的大脑机制， 将来可能有助于指导更有效的行为修复。这项工作可能构成重要的基础 未来的研究使用跨模式脑成像标记来评估阅读障碍中的这种补救方法。