Changes in the reading network of dyslexia as measured by multimodal imaging

通过多模态成像测量阅读障碍阅读网络的变化

基本信息

批准号：
8298972
负责人：
KRISTI A CLARK
金额：
$ 8.6万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-08 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8298972
关键词：
12 year old 6 year old Address Affect Age Area Award Behavior Therapy Behavioral Brain Brain imaging Brain region California Child Childhood Clinical Cognitive Control Groups Data Data Set Development Developmental reading disorder Diffusion Dyslexia Education Educational Intervention Faculty Feeling Future Goals Growth Image Image Analysis Individual Intervention Knowledge Learning Longitudinal Studies Los Angeles Measures Mentors Mentorship Methods Multimodal Imaging Nature Neurobiology Neuropsychological Tests Neurosciences Norway Orthography Performance Phase Philosophy Plastics Population Positioning Attribute Postdoctoral Fellow Psychological Theory Public Health Reader Reading Reading Disorder Research Research Personnel Sampling Schools Socioeconomic Status Structure System Testing Thick Time Training Universities Variant Work Writing aged base career cognitive neuroscience cohort design experience insight literacy meetings neuroimaging outcome forecast phonology remediation research study skills theories

项目摘要

DESCRIPTION (provided by applicant): This K99/R00 award will support the candidate's goal for developing a career as an independent researcher in the field of developmental neuroscience, particularly with regard to the study of dyslexia. The candidate is currently a postdoctoral fellow with considerable research experience in functional and diffusion neuroimaging and has strong computational skills. Training will take place primarily at the University of California, Los Angeles (UCLA) under the primary mentorship of Dr. Arthur Toga, an expert on basic neuroimaging studies, and with the guidance of co-mentor Dr. Katherine Narr, an expert on clinical neuroimaging studies. Additional training will take place at the University of Southern California (USC) under the mentorship of co-mentor Dr. Franklin Manis, an expert on the psychological theories of dyslexia. The training component of this award will focus on three main areas: 1) expanding the candidate's general knowledge about developmental cognitive neuroscience and more specific knowledge regarding current theories relating to dyslexia; 2) developing practical skills in acquiring and integrating multimodal neuroimaging data in pediatric cohorts; and 3) developing skills in administering and interpreting the results of neuropsychological tests. Research conducted during the mentored phase of this award will take advantage of an existing longitudinal imaging dataset obtained from prominent investigators in the field of dyslexia to address important hypotheses concerning the systems-level neurobiological correlates of dyslexia prior to reading age or that occur in association with brain maturation during childhood in subjects followed prospectively. Acquisition of structural, functional and diffusion imaging data from new groups of children with dyslexia and reading-level and age-matched controls will be a focus during the R00 phase. During this phase, the candidate will use this independent sample to further develop and apply highly sophisticated multimodal computational image analysis methods to dissociate disturbances in distinct and/or overlapping brain networks that will specifically address the precise nature of reading and writing disturbances in dyslexia. The training plan is designed to fill the gaps in the candidate's previous academic career so that she can successfully attain a tenure-track faculty position at a research university. The research plan is designed to provide insight into the brain mechanisms underlying dyslexia that may help direct more effective behavioral remediation in the future. This work may form an important basis for future studies using cross-modal brain imaging markers to evaluate such remediation approaches in dyslexia.

描述（由申请人提供）：该K99/R00奖将支持候选人在发育神经科学领域发展职业的目标，尤其是在阅读障碍研究方面。该候选人目前是博士后研究员，在功能和扩散神经影像学方面具有丰富的研究经验，并且具有强大的计算能力。培训将主要在加利福尼亚大学，洛杉矶分校（UCLA）下，在基础神经影像学研究专家Arthur Toga博士的主要指导下，并在同事Katherine Narr博士的指导下。在南加州大学（USC）的指导下，南加州大学（USC）将进行额外的培训。该奖项的培训部分将重点放在三个主要领域：1）扩大候选人关于发育认知神经科学的一般知识，以及有关与阅读障碍有关的当前理论的更具体知识； 2）在儿科队列中获得和整合多模式神经影像数据方面的实践技能； 3）在管理和解释神经心理学测试结果方面发展技能。在该奖项的指导阶段进行的研究将利用从阅读障碍领域的著名研究人员获得的现有纵向成像数据集，以解决有关在阅读年龄之前或阅读年龄之前的系统级神经生物学相关性的重要假设，或者是在阅读年龄之前与脑部成熟在受试者中的大脑成熟时发生的。在R00阶段，从诵读困难和阅读水平和年龄匹配的对照组中获取结构，功能和扩散成像数据将成为重点。在此阶段，候选人将使用此独立样本来进一步开发和应用高度复杂的多模式计算图像分析方法，以分离不同和/或重叠的脑网络中的干扰，这些干扰将专门解决阅读障碍中阅读和写作障碍的精确性质。该培训计划旨在填补候选人以前的学术职业的空白，以便她可以成功地在一所研究大学获得终身教师职位。该研究计划旨在洞悉阅读障碍的大脑机制，这可能有助于将来指导更有效的行为修复。这项工作可能是使用跨模式脑成像标记来评估阅读障碍方法的未来研究的重要基础。