Neural and developmental trajectories of females with autism spectrum disorder

患有自闭症谱系障碍的女性的神经和发育轨迹

• 批准号: 10443473
• 负责人: Christine Wu Nordahl
• 金额: $ 79.63万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10443473
• 关键词: 12 year old; 6 year old; Address; Age; Amygdaloid structure; Area; Attention deficit hyperactivity disorder; Attenuated; Behavioral; Biological Markers; Brain; Brain region; Caring; Data; Detection; Development; Diagnosis; Diagnostic; Disease; Emotional; Enrollment; Etiology; Exhibits; Female; Feminization; Gender; General Population; Goals; Hyperactivity; Impulsivity; Individual; Knowledge; Lead; Literature; Longevity; Longitudinal Studies; Longitudinal cohort; Masculine; Medicine; Modeling; Participant; Pattern; Prevalence; Protocols documentation; Psychopathology; Research; Risk Factors; Sampling; Sampling Studies; Self-Injurious Behavior; Sex Differences; Strategic Planning; Symptoms; System; Testing; Theoretical model; Time; United States Dept. of Health and Human Services; United States National Institutes of Health; Woman; Women' s Health; attenuation; autism spectrum disorder; autistic; base; behavioral phenotyping; boys; cohort; disorder risk; early childhood; emotion dysregulation; emotion regulation; ethnic minority population; externalizing behavior; girls; imaging study; inattention; individuals with autism spectrum disorder; insight; male; middle childhood; neuroimaging; optimal treatments; outcome prediction; peer; phenome; programs; protective effect; racial minority; recruit; relating to nervous system; restrictive repetitive behavior; sensorimotor system; serial imaging; sex; theories; 12 year old; 6 year old; Address; Age; Amygdaloid structure; Area; Attention deficit hyperactivity disorder; Attenuated; Behavioral; Biological Markers; Brain; Brain region; Caring; Data; Detection; Development; Diagnosis; Diagnostic; Disease; Emotional; Enrollment; Etiology; Exhibits; Female; Feminization; Gender; General Population; Goals; Hyperactivity; Impulsivity; Individual; Knowledge; Lead; Literature; Longevity; Longitudinal Studies; Longitudinal cohort; Masculine; Medicine; Modeling; Participant; Pattern; Prevalence; Protocols documentation; Psychopathology; Research; Risk Factors; Sampling; Sampling Studies; Self-Injurious Behavior; Sex Differences; Strategic Planning; Symptoms; System; Testing; Theoretical model; Time; United States Dept. of Health and Human Services; United States National Institutes of Health; Woman; Women' s Health; attenuation; autism spectrum disorder; autistic; base; behavioral phenotyping; boys; cohort; disorder risk; early childhood; emotion dysregulation; emotion regulation; ethnic minority population; externalizing behavior; girls; imaging study; inattention; individuals with autism spectrum disorder; insight; male; middle childhood; neuroimaging; optimal treatments; outcome prediction; peer; phenome; programs; protective effect; racial minority; recruit; relating to nervous system; restrictive repetitive behavior; sensorimotor system; serial imaging; sex; theories

Girls and women are understudied in autism spectrum disorder (ASD) research because study samples often reflect the male predominance in ASD prevalence, with 3-4 boys diagnosed for every girl. Longitudinal imaging studies with sufficient numbers of females are completely lacking. To address this important gap in knowledge, we aim to evaluate brain and behavioral trajectories from early to middle childhood in a large, longitudinal cohort of nearly 100 girls with autism. As the field moves towards identifying neural biomarkers for ASD risk and predicting outcomes, it is critical to understand similarities and differences between males and females with ASD across the lifespan. Another serious need is to better understand co-occurring psychiatric conditions in females with ASD. It is well-recognized that individuals with autism have high rates of co-occurring psychopathology, but little is known about early behavioral and neural risk factors that may be specific to girls. As in so many other areas of medicine, the optimal treatment of girls and women with ASD will only emerge when sex-related autism attributes and problems are adequately understood. In 2014, we established the Girls with Autism – Neuroimaging of Development (GAIN) study, which increased representation of females with ASD in a larger ongoing project called the Autism Phenome Project and followed a cohort of girls across three time points from 2-6 years of age. With this application, we plan to conduct a fourth longitudinal time point in GAIN participants during middle childhood (9-12 years of age). In addition, in order to increase generalizability of findings, we plan to enroll new girls into the study with a focus on racial and ethnic minority groups that have historically been under-represented. Newly enrolled girls will follow the same study protocols established by the GAIN study and data will be combined. We propose the following aims: 1) To identify sex-specific neural and behavioral patterns in girls with ASD in early and middle childhood. 2) To identify sex differences in neural risk factors associated with symptoms of internalizing and externalizing psychopathology in middle childhood. 3) To characterize the emergence and impact of symptoms of attention deficit/hyperactivity disorder (ADHD) in girls with ASD. Evaluating females with ASD is a cross-cutting goal that spans all objectives of the US Department of Health & Human Services Interagency Autism Coordinating Committee and is also consistent with the goals of the Trans-NIH Strategic Plan for Women’s Health Research.

在自闭症谱系障碍（ASD）研究中对女孩和妇女进行了理解，因为研究样本经常 反映ASD患病率的男性占主导地位，每个女孩被诊断出3-4个男孩。纵向成像 完全缺乏足够数量的女性的研究。为了解决知识中的这一重要差距， 我们旨在评估从童年早期到中期的大脑和行为轨迹 近100名自闭症女孩的队列。随着领域朝着识别ASD风险的神经生物标志物的发展 并预测结果，了解男性和女性之间的相似性和差异至关重要 与ASD跨越寿命。另一个严重的需求是更好地了解同时发生的精神病 在ASD的女性中。众所周知，自闭症患者的同时发生率很高 心理病理学，但对可能针对女孩的早期行为和神经危险因素知之甚少。 就像在许多其他医学领域一样，对ASD的女孩和女性的最佳治疗只会出现 当与性相关的自闭症属性和问题充分理解时。 2014年，我们建立了女孩 自闭症 - 发展（增益）研究的神经影像学，这增加了女性的代表性 ASD在一个较大的正在进行的项目中，称为自闭症现象项目，并跟随三个女孩队列 2-6岁的时间点。通过此应用，我们计划在 在童年（9-12岁）中获得参与者。另外，为了提高普遍性 从调查结果中，我们计划将新女孩纳入研究，重点是种族和少数民族群体 从历史上看，人为不足。新入学的女孩将遵循相同的研究协议 增益研究和数据将合并。我们提出以下目的：1）确定性别特定性的中性 在童年早期和中期的ASD女孩中的行为模式和行为模式。 2）确定神经元的性别差异 与儿童中期内在化和外在心理病理学的症状相关的危险因素。 3）表征注意力不足/多动症（ADHD）症状的出现和影响 有ASD的女孩。用ASD评估女性是一个跨切割目标，跨越了美国的所有目标 卫生与公共服务部机构间自闭症协调委员会，也是一致的 凭借《跨NIH妇女健康研究战略计划》的目标。