IDENTIFICATION OF HUMAN PROTEINS IN A MOUSE XENOGRAPH MODEL

小鼠异种模型中人类蛋白质的鉴定

• 批准号: 8365848
• 负责人: Christine Wu Nordahl
• 金额: $ 0.65万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365848
• 关键词: A Mouse; Biology; Collaborations; Fatty acid glycerol esters; Funding; Fungal Genome; Genes; Grant; Harvest; Human; Human Genome; Human Identifications; Modeling; Mus; National Center for Research Resources; Plasma; Principal Investigator; Proteins; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Identification of proteins that are secreted from a tumor into plasma is a daunting analytical challenge. In collaboration with the Lewis lab, human tumors were placed into the fat pad of mice. Plasma was harvested from mice and we hope to analyze the plasma to identify proteins that originate from genes encoded by the human genome.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 从肿瘤分泌为血浆的蛋白质鉴定是一个艰巨的分析挑战。与刘易斯实验室合作，将人类肿瘤放入小鼠的脂肪垫中。血浆是从小鼠那里收集的，我们希望分析血浆，以鉴定源自人类基因组编码的基因的蛋白质。