Expanding independent research capacity in HIV-associated malignancies in Uganda

扩大乌干达艾滋病毒相关恶性肿瘤的独立研究能力

• 批准号: 8708481
• 负责人: Corey Casper
• 金额: $ 30.46万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708481
• 关键词: Acquired Immunodeficiency Syndrome; Area; Award; Carcinogens; Caring; Cause of Death; Clinical; Country; Doctor' s Degree; Fred Hutchinson Cancer Research Center; Grant; HIV; HIV Infections; HIV Seropositivity; HIV diagnosis; Health; High Prevalence; Hybrids; Incidence; Individual; Institutes; Interview; Kaposi Sarcoma; Life; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Measures; Mentors; Non-Hodgkin' s Lymphoma; Operations Research; Persons; Primary carcinoma of the liver cells; Research; Research Project Grants; Resources; Scientist; Structure; Training; Training Activity; Uganda; Universities; Viral; Washington; antiretroviral therapy; cancer prevention; cancer therapy; career development; experience; informant; medical schools; oncology; programs

DESCRIPTION (provided by applicant): The incidence of cancer among persons with HIV infection has increased annually since the widespread availability of antiretroviral therapy. Cancer is now a leading cause of death among HIV-positive persons, as survival after a diagnosis of an HIV-associated malignancy (HIVAM) is poorer compared with HIV-negative cancers across the world. In regions with a high prevalence of both HIV and viral oncogens, AIDS-defining malignancies such as Kaposi Sarcoma, non-Hodgkin lymphoma and cervical cancer present some of the largest threats to the health of HIV-infected individuals; non-AIDS defining cancers such at hepatocellular carcinoma, lung cancer and anal cancer now comprise >50% of HIVAM. New strategies are needed for cancer prevention and treatment among persons living with HIV in resource-limited settings. Since 2004, the Fred Hutchinson Cancer Research Center (FHCRC) has collaborated with the Uganda Cancer Institute (UCI) in Kampala, Uganda, to conduct research in HIVAM and develop new strategies for cancer treatment and prevention. Through several well-established training grants and strong relationships with our academic partners, the University of Washington (UW) and Makerere University (MU), we have trained >250 individuals in HIVAM research and care at all levels. Key informant interviews with academic, governmental and clinical leaders in Uganda find that a few gaps in the capacity to conduct HIVAM research persist. We propose to increase the capacity for independent research in HIVAM in Uganda through three Specific Aims: 1) Increase the number of Ugandan research scientists in HIVAM through the conferral of doctoral degrees with an established hybrid program between UW and MU; 2) Build the capacity for independent scientific research in HIVAM through a structured program of mentoring and career development; 3) Maintain capacity to implement HIVAM research in Uganda through ongoing short-term trainings in areas fundamental to research operations. The training activities will be overseen by an experienced and outstanding committee representing leaders in HIV and oncology research from the US and all Deans from three medical schools distributed across the country of Uganda, and will be rigorously measured and evaluated. By the completion of the five-year award period, >130 individuals will be trained in HIVAM research in Uganda, allowing for the conduct of a wide variety of research projects in HIVAM.

描述（由申请人提供）：自抗逆转录病毒疗法的广泛可用性以来，艾滋病毒感染患者的癌症发生率每年增加。癌症现在已成为HIV阳性患者死亡的主要原因，因为与全世界的HIV阴性癌症相比，与HIV相关的恶性肿瘤（HIVAM）诊断后的生存较差。在艾滋病毒和病毒性毒素较高患病率的地区，艾滋病定义恶性肿瘤，例如卡波西肉瘤，非霍奇金淋巴瘤和宫颈癌，构成了对艾滋病毒感染者健康的一些最大威胁；现在，在肝细胞癌，肺癌和肛门癌中定义癌症的非AID占HIVAM> 50％。在资源有限的环境中，需要新的策略来预防艾滋病毒的人群癌症和治疗。自2004年以来，弗雷德·哈钦森癌症研究中心（FHCRC）与乌干达坎帕拉的乌干达癌症研究所（UCI）合作，在HIVAM进行研究，并制定了新的癌症治疗策略。通过与我们的学术合作伙伴，华盛顿大学（UW）和Makerere University（MU）的几项公认的培训补助金以及牢固的关系，我们在所有级别的HIVAM研究和护理方面都培训过> 250个人。与乌干达的学术，政府和临床领袖的主要线人访谈发现，进行Hivam Research的一些差距仍然存在。我们建议通过三个具体目标来提高乌干达HIVAM独立研究的能力：1）通过博士学位授予HIVAM的乌干达研究科学家的数量，并在UW和MU之间建立了混合计划； 2）通过指导和职业发展的结构化计划在HIVAM中建立独立科学研究的能力； 3）通过在研究运营基础的地区进行的短期培训来维持在乌干达实施HIVAM研究的能力。培训活动将由经验丰富且杰出的委员会监督，代表来自美国的艾滋病毒和肿瘤学研究领导者以及来自乌干达国家的三所医学院的所有院长，并将进行严格的衡量和评估。到五年奖励期结束时，将在乌干达的HIVAM研究中接受> 130名个人的培训，从而允许在Hivam进行各种研究项目。