Research Program: Global Oncology

研究项目：全球肿瘤学

• 批准号: 9001929
• 负责人: Corey Casper
• 金额: $ 8.72万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9001929
• 关键词: Adult; Africa; Area; Cancer Biology; Cancer Center; Cancer Center Support Grant; Child; Childhood; China; Clinical Trials; Country; Data; Detection; Evaluation; Faculty; Faculty Recruitment; Foundations; Funding; Goals; Guidelines; HIV; HIV Long-Term Survivors; Health; Human; Imagery; Individual; Information Systems; Institutes; Interdisciplinary Study; International; Lead; Longevity; Malignant Neoplasms; Methods; Molecular Profiling; Obesity; Paper; Peer Review; Prevention; Prevention approach; Publishing; Research; Research Infrastructure; Research Personnel; Resources; Risk Factors; Schools; Scientist; Site; Smoking; South Africa; Specimen; Uganda; Universities; University resources; Washington; Work; abstracting; burden of illness; cancer prevention; cancer risk; cancer therapy; common treatment; design; improved; infection related cancer; inter-institutional; low and middle-income countries; member; mortality; novel; oncology; programs; repository; statistics; trend; tumor

Program in Global Oncology Project Summary/Abstract Cancer is increasingly recognized as a threat to the health of people worldwide. Current estimates are that 70% of new cancer cases will be in low- and middle-income countries by 2020. Drivers of these statistics include increasing life spans due to overall health and reductions in childhood and adult mortality; increasing obesity; higher smoking rates; and, in Africa, increasing rates of cancer associated with the growing number of long-term survivors of HIV. These trends are likely to continue. Cancer mortality rates are also higher in resource-poor economies. The goal of the Program in Global Oncology (PiGO) is to develop a robust research program that allows in- country investigators to develop data-driven approaches to the prevention and treatment of cancers of relevance in their region, as well as to develop a robust research enterprise that leverages the resources and opportunities in these countries to increase our understanding of cancer, especially those that are rare in the developed world and common in the developing world. Research conducted outside the U.S. has elucidated novel cancer risk factors, described unique molecular signatures for common malignancies, and suggested potential new strategies for cancer prevention and treatment. PiGO leverages the resources of our Cancer Center to lead effective research outside the U.S. through four Specific Aims: 1) Leverage data systems, methods and visualization to support global surveillance of cancer; 2) Expand our studies of tumors from HIV- infected and non-HIV-infected individuals to determine how and whether these cancers differ, utilizing the human and physical infrastructure we have developed in Uganda, South Africa and select areas in China; 3) Further develop a robust multidisciplinary research program to discover novel infection-related cancers, with particular emphasis on HIV-infected individuals; and 4) Develop effective in-country guidelines to improve the detection, potential prevention and treatment of common cancers found in resource poor settings. PiGO has 35 members drawn from 3 schools and 18 departments of FHCRC, UW and Children's, and $4.5M in peer-reviewed funding (direct dollars) in fiscal year 2013, of which $2.6M (49%) is from NCI. The program also has $ 21.4M (cancer-relevant portion) from the Bill and Melinda Gates Foundation. Members have published 322 papers, of which 10% are intra-programmatic, 33% are intra-programmatic and 18% are inter- institutional.

全球肿瘤学计划 项目摘要/摘要 越来越多的癌症被认为是对全世界人民健康的威胁。当前的估计是 到2020年，70％的新癌症病例将在低收入和中等收入国家。 包括由于整体健康以及童年和成人死亡率的减少而增加寿命的增加；增加 肥胖;较高的吸烟率；并且，在非洲，癌症发生率不断增长 艾滋病毒的长期幸存者。这些趋势可能会继续下去。癌症死亡率也更高 资源贫乏的经济体。 该计划在全球肿瘤学（PIGO）中的目标是制定一个可靠的研究计划 国家调查人员开发以数据为基础的方法来预防和治疗癌症 在其地区的相关性，以及开发一家强大的研究企业，利用资源和资源 这些国家的机会增加了我们对癌症的理解，尤其是那些在 发达的世界，在发展中国家中常见。在美国境外进行的研究已经阐明 新颖的癌症危险因素描述了常见恶性肿瘤的独特分子特征，并建议 潜在的预防癌症和治疗的新策略。 Pigo利用我们癌症的资源 通过四个特定目标领导美国以外有效研究的中心：1）利用数据系统， 支持全球癌症监测的方法和可视化； 2）扩大我们对HIV的肿瘤的研究 感染和非HIV感染的个体，以确定这些癌症是如何以及如何不同的 我们在乌干达，南非和中国精选地区开发的人类和身体基础设施； 3） 进一步制定了一个强大的多学科研究计划，以发现与感染有关的新型癌症 特别强调感染HIV的人； 4）制定有效的国内准则以改善 在资源较差的环境中发现的常见癌症的检测，预防和治疗。 Pigo有35名成员来自3所学校和FHCRC，UW和儿童的18个部门，450万美元 在2013财年进行同行评审的资金（直接美元）中，其中260万美元（49％）来自NCI。该程序 还拥有比尔和梅琳达·盖茨基金会（Bill and Melinda Gates Foundation）的2140万美元（与癌症相关的部分）。成员有 已发表的322篇论文，其中10％是概括性的，33％是概括性的，18％是间隔的 机构。