Nonhuman Primate Core

非人类灵长类核心

基本信息

批准号：
8376405
负责人：
Michael K Axthelm
金额：
$ 50.1万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-03-01 至 2014-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8376405
关键词：
Animal Experimentation Animal Model Animals Autopsy Biomedical Research Body Composition Centers of Research Excellence Cercopithecidae Clinical Clinical Management Competence Complex Cost Savings Data Dengue Drug or chemical Tissue Distribution Ebola virus Emerging Communicable Diseases Evaluation Frankfurt-Marburg Syndrome Virus Genetic Goals Human Immune system Immunologics Immunology Infectious Agent Infectious Diseases Research Influenza Influenza A Virus, H5N1 Subtype Investigation Junin virus Laboratories Laboratory Personnel Life Metabolism Modeling Monitor Monkeypox virus Oregon Pacific Northwest Pathogenesis Pathologic Physiological Primates Reproduction Research Research Infrastructure Resources Safety Services Specimen Handling Structure Technical Expertise Tissue Banking Tissue Banks Tissue Sample Training Virus Washington West Nile virus Yellow fever virus animal breeding animal resource comparative efficacy testing human disease infrastructure development meetings member nonhuman primate performance site research and development research facility safety study sample collection vaccine development

项目摘要

The Nonhuman Primate (NHP) Core is a multicenter Core structured to provide the Pacific Northwest Regional Center of Excellence (PNWRCE) with resources for purpose-bred animals and unique facilities and specialized investigative and technical expertise for infectious disease research that is best conducted using NHPs. The Core's performance sites include the Oregon and Washington National Primate Research Centers (ONPRC Beaverton, OR, and WaNPRC, Seattle, WA), and the Integrated Research Facility (IRF) on the Rocky Mountain Laboratories (RML) campus, Hamilton, MT. Nonhuman primates are unique, long-lived species that share many physiologic similarities with humans. These similarities include body composition, maturation, reproduction, metabolism and close genetic relatedness. Of NHPs available for research, Old World monkey species have the closest evolutionary relationship to humans and they are essential surrogates for biomedical research focused on major human diseases that lack suitable alternative animal models. The organization and function of the NHP immune system closely resembles that of humans and their contribution to understanding the complex interrelationships of the different components of the immune system in the defense against infectious agents is particularly notable. Nonhuman primates have long been recognized for their value as comparative models for human vaccine development, efficacy testing and safety evaluation, and for the investigation of fundamental questions in basic immunology. Many of these models have demonstrated merit for pathogenesis research and vaccine development to contain emerging and re-emerging infectious diseases, H5N1 and 1918 influenza (1-3), Ebola and Marburg viruses (4), monkey pox virus (5, 6), West Nile virus (7, 8), Junin virus (9), yellow fever virus and Dengue fever virus (10, 11). Their research value notwithstanding, NHPs are complex, higher order species that require specialized expertise, infrastructure and staff in a research setting.

非人类灵长类 (NHP) 核心是一个多中心核心，旨在为太平洋西北地区提供服务区域卓越中心 (PNWRCE) 拥有专门饲养的动物资源和独特的设施以及最佳传染病研究的专业调查和技术专长使用 NHP。核心表演场地包括俄勒冈州和华盛顿国家灵长类动物表演场研究中心（俄勒冈州比弗顿 ONPRC 和华盛顿州西雅图 WaNPRC）以及综合研究中心位于蒙大拿州汉密尔顿落基山实验室 (RML) 园区的设施 (IRF)。非人类灵长类动物是独特、长寿的物种，与人类有许多生理相似之处。这些相似之处包括身体成分、成熟、繁殖、代谢与遗传密切相关。可用的 NHP 就研究而言，旧大陆猴子物种与人类具有最密切的进化关系，并且它们是生物医学研究的基本替代物集中于缺乏合适的人类主要疾病替代动物模型。 NHP 免疫系统的组织和功能与人类的存在及其对理解不同事物之间复杂的相互关系的贡献免疫系统的组成部分在防御传染性病原体方面尤其值得注意。非人类灵长类动物长期以来因其作为人类疫苗比较模型的价值而得到认可开发、功效测试和安全性评价，以及研究基本问题基础免疫学。许多这些模型已被证明在发病机制研究和疫苗方面具有价值遏制新出现和再次出现的传染病、H5N1 和 1918 流感 (1-3)，埃博拉病毒和马尔堡病毒 (4)、猴痘病毒 (5、6)、西尼罗河病毒 (7、8)、胡宁病毒 (9)、黄热病病毒和登革热病毒 (10, 11)。尽管 NHP 具有研究价值，但它们非常复杂、更高订购需要专门知识、基础设施和研究人员的物种。