Phase 2 Enhancement of Outdoor Group Housing for U42 SPF 9 Rhesus Macaques

U42 SPF 9 恒河猴户外群舍第二期强化工程

• 批准号: 10360780
• 负责人: Michael K Axthelm
• 金额: $ 50万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360780
• 关键词: AIDS vaccine development; AIDS-Related Opportunistic Infections; Acquired Immunodeficiency Syndrome; Address; Adult; Adult Children; Animal Husbandry; Animal Welfare; Animals; Area; Breeding; Clinical; Development; Environmental Protection; Female; Floor; Funding; Genetic; Goals; Health Sciences; Housing; Individual; Infant; Infrastructure; Lymphocryptovirus; Macaca; Macaca mulatta; Modification; Oregon; Phase; Population; Primates; Procedures; Production; Request for Applications; Research; Shelter facility; Social Welfare; Solid; Source; Structure; Universities; Viral; Water; Weather; animal breeding; animal care; design; flexibility; improved; male; man; mature animal; offspring; prevent; recruit; seroconversion; social; social group; square foot; symposium; transmission process; vector vaccine

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) Expanded SPF (ESPF) Rhesus Macaque Breeding Colony is a highly specialized breeding colony that provides unique and essential macaques with an expanded SPF definition for AIDS research. This colony is critical for AIDS-related opportunistic infection research and vaccine vector development using opportunistic viral agents as vaccine vectors. In order to provide a sufficient number of appropriate animals, the breeding colony must produce 30 surplus animals annually. Concurrently, it is necessary to isolate lymphocryptovirus (LCV) free animals and re-derive LCV-free offspring from LCV seroconverted females in the colony and recruit additional LCV-free infants from Center's convention SPF colony. A critical shortage of appropriate ESPF social housing severely constrain both our efforts to increase the size of the breeding colony to meet project demand and our endeavors to eliminate LCV from the colony. The application proposes to complete modifications of the existing southwest outdoor sheltered housing structure providing an additional four 500 sq. ft. social housing units. The proposed modifications would expand the total number of outdoor ESPF breeding animals housed in social groups permitting increased production, facilitate genetic management by providing smaller housing units that are more appropriate for housing 7-10 females and a male and offspring, provide sufficient separation between individual housing units to prevent transmission of agents between groups, and improve animal welfare through social housing.

项目概要 俄勒冈国家灵长类研究中心 (ONPRC) 扩大 SPF (ESPF) 恒河猴育种 Colony 是一个高度专业化的繁殖群，为独特而重要的猕猴提供了扩展的 艾滋病研究的 SPF 定义。该菌落对于艾滋病相关的机会性感染研究和研究至关重要 使用机会病毒剂作为疫苗载体开发疫苗载体。为了提供足够的 适当数量的动物，繁殖群体每年必须生产 30 只剩余动物。同时，它 有必要分离无淋巴隐病毒 (LCV) 的动物并从 LCV 中重新衍生出无 LCV 的后代 在群体中进行血清转化的雌性，并从中心的 SPF 大会中招募更多无 LCV 的婴儿 殖民地。适当的 ESPF 社会住房的严重短缺严重限制了我们增加收入的努力 满足项目需求的繁殖群体规模以及我们消除群体中 LCV 的努力。 申请书拟完成现有西南户外防护住房的改造 结构提供额外的四个 500 平方英尺的社会住房单元。拟议的修改将 扩大社会群体中户外 ESPF 繁殖动物的总数，允许增加 生产，通过提供更适合的较小住房单元来促进遗传管理 容纳 7-10 只雌性和一只雄性及其后代，在各个住房单元之间提供足够的隔离 防止群体之间传播病原体，并通过社会住房改善动物福利。